Structure of PDB 6hiw Chain Cm Binding Site BS01

Receptor Information
>6hiw Chain Cm (length=196) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RQHDSGVNQYGLKPTNAYDYINPTNLINFGRGTTFDNLGVRRAGRGEIDS
SPSHSGSPVFTQAKLIGLSGEEQLTMCQSETMALRLCMAKAGKETCERES
RALDSCLGRVGHLRRAMSEACWEFNDWFIQNVSDNHTKPFQHRPHDWRHF
YAQEKLVRERQQNGHAYGRRPKQFSFGARYVKTDGYGKRPRLPYNK
Ligand information
>6hiw Chain CA (length=621) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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ucauuuuauaaagguuuauuuuugaaagauuuuuuguauaaaauuuuagg
aauaguuaauaauaauuuauaauuuugauuagauuguuuuguuaaugcua
uuagauggguguggaaaaauaaaaaaaauaauuaauauauaucaauaaua
aauuaaauuaaucuauuagucagaaauggaugccagccguugcgguaauu
ucuaugcuuuuaaauauuauacaauuaucauauuaaauuguuaaguguug
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uaaggauuauaaauugaaaguguuaauaucauaaucaaaauuuauuauuu
auauuaaauauguauguguagauaaaauaagaaauuaaaaagguauuguu
gcccaccaauuuuuauaauaaaaauaacgugcaguaauuaauauauuuau
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....................<<<.......<<<<..............<.
..>..........................................<....
.<<...<<<.......>>>..>>........>........<<....>>..
..................................................
.................<<<.(...<<<<<.....<<..).>>.......
>>>>>>>>.......>>>>............<..................
.<.......>.....................>............<<<...
.>>>................<......>..>>>..<<.............
.<<<<<............................................
..................................................
.....................>>>>>..................>>....
<<.<<<..<<<<<<.....>>>>>>...>>>..>>....<<<<<<<<<..
..>>>>>>>>>..........
Receptor-Ligand Complex Structure
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PDB6hiw Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Resolution3.37 Å
Binding residue
(original residue number in PDB)
Y37 N41 T43 N44 N47 R50 G65 E66 D68 S70 P77 F79 Q81 A82 K83 S88 R133 R134 S137 C140 W141 H161 R162 H164 R167 K174 Q180 N182 H184 A185 Y186 R188 R189 K191 Q192 F193 F195 G196 R198 Y199 V200 K201 T202 G204 Y205 R208 R210 L211 Y213 N214 K215
Binding residue
(residue number reindexed from 1)
Y18 N22 T24 N25 N28 R31 G46 E47 D49 S51 P58 F60 Q62 A63 K64 S69 R114 R115 S118 C121 W122 H142 R143 H145 R148 K155 Q161 N163 H165 A166 Y167 R169 R170 K172 Q173 F174 F176 G177 R179 Y180 V181 K182 T183 G185 Y186 R189 R191 L192 Y194 N195 K196
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:6hiw, PDBe:6hiw, PDBj:6hiw
PDBsum6hiw
PubMed30213880
UniProtQ38C96

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