Structure of PDB 4v6x Chain Ci Binding Site BS01

Receptor Information

>4v6x Chain Ci (length=103) Species: 9606 (Homo sapiens)

MALRYPMAVGLNKGHKVTKNVSKPRHSRRRGRLTKHTKFVRDMIREVCGF
APYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKA
AAK

Ligand information

>4v6x Chain A5 (length=4298)

cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggguccggccgugucggcgg
cccggcggaucuuucccgccccccguuccucccgaccccuccacccgccc
ucccuucccccgccgccccgggcuccggcgggugcgggggugggcgggcg
gggccggggguggggucggcgggggaccgucccccgaccggcgaccggcc
gccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccggga
cggcugggaaggcccggcggggaagguggcucggggggccccguccgucc
guccggcggcggcggcggcggcgggaccgaaaccccccccgaguguuaca
gcccccccggcagcagcacucgccgaaucccggggccgagggagcgagac
ccgucgccgcgcucuccccccucccggcgcccacccccgcggggacuccc
ccgcgggggcgcgccggcgucuccucgugggggggccgggccaccccucc
cacggcgcgaccgcucucccaccccuccuccccgcgcccccggggugccg
cgcgcgggucggggggcggggcggacuguccccagugcgccccgggcggg
ucgcgccgucgggcccgggggagguucucucggggccacgcgcgcguccc
ccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucgg
cuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugc
gcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaagg
ccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgcc
gagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagca
cgagcgcacguguuaggacccgaaagauggugaacuaugccugggcaggg
cgaagccagaggaaacucugguggagguccguagcgguccugacgugcaa
aucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucua
guagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcag
acccgacgcacccccgccacgcaguuuuauccgguaaagcgaaugauuag
aggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaugggu
aagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccua
gugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgc
cggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguu
gguugauauagacagcaggacgguggccauggaagucggaauccgcuaag
gaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugg
cgcuggagcgucgggcccauacccggccgucgccggcagucgagagugga
cgggagcggcgggggcggcgcgcgcgcgcgcgcguguggugugcgucgga
gggcggccuccucccgcccacgccccgcuccccgcccccggagccccgcg
gacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagcc
uagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguag
uagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguucc
augugaacagcaguugaacaugggucagucgguccugagagaugggcgag
cgccguuccgaagggacgggcgauggccuccguugcccucggccgaucga
aagggagucggguucagauccccgaauccggaguggcggagaugggcgcc
gcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcggga
gccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaau
ggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccg
gcggcguccggugagcucucgcuggcccuugaaaauccgggggagagggu
guaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggug
aacagccucuggcauguuggaacaauguagguaagggaagucggcaagcc
ggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgg
gcuggggcgcgaagcggggcugggcgcgcgccgcggcuggaucuggacgc
gagccgggcccuucccguggaucgccccagcugcggcgggcgucgcggcc
gcgcgguuccgcgcggcgccucgccucggccggcgccuagcagccgacuu
agaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcau
cgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcu
cugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggag
uaacuaugacucucuuaagguagccaaaugccucgucaucuaauuaguga
cgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccag
cgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaag
acccuguugagcuugacucuagucuggcacggugaagagacaugagaggu
guagaauaagugggaggcccccggcgcccccccgguguccccgcgagggg
cccggggcgggguccgccggcccugcgggccgccggugaaauaccacuac
ucugaucguuuuuucacugacccggugaggcgggggggcgagccccgagg
ggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcga
cccgcuccggggacagugccagguggggaguuugacuggggcgguacacc
ugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaa
ccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagua
cgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggg
uuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuugug
gcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcu
cuuccuaucauugugaagcagaauucaccaagcguuggauuguucaccca
cuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuu
uacccuacugaugauguguuguugccaugguaauccugcucaguacgaga
ggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaau
ggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucaga
aucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggcc
ucggauagccggucccccgccuguccccgccggcgggccgcccccccccu
ccacgggagggcgcgugccccgccgcgcgccgggaccgggguccggugcg
gagugcccuucguccugggaaacggggcgcggccggagaggcggccgccc
ccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccau
ucguagacgaccugcuucugggucgggguuucguacguagcagagcagcu
cccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc

.........................<<<<<<.....<......>......
>>>>>.>...{.....<<....>>..<<<<<<.....<<.....>>....
>>>>>>..[[[....<<<...<<<<<<<<<<<...>>>>>>>.>>>>...
..>>>....<<<<<<<<<<...<<<<<<<<.<<<....<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>>>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>
>>>>.....(((((..<<<<<<)))))..]]]....}.............
................<<....>>...............<<<<....>>>
>..................................<<<<<<<<..<<<.<
....<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<.
....<<<<.<<<..<<<<<<<<<<<....<<<<<.<<<<....<<<<<<<
.<<<<<<.<<<<<<<.<<<>>>...>>>>>>>.>.>>>>>.>>>>>>>.>
>>>.>>>>>.>>>>>..>>>>>>>>>>>>>.>>>.>>>......>>>.>>
>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<<.<<<<<<<<<..
<<<<..........<<<.<<<<...<<.<<<<<<<<.<<<<<<.<<<.<<
<.<<<.>>>>>>>>>>>>.>>>..............>>>>>>>>>.>...
.>>>>.>>>............>>>>....>>>>>>>>>............
.....<..<<<<...<<<<<<<..<<<<<<...<<<<<<<<<<<....>>
>>>>>>>>>.>>>>>><........>..>>>>>>>...<<<<.<<<<..<
<<<<<<<<<<<<<<<...<<.<<<...<<<..<<<<<<<<<>>>>.>>.>
>>...>>>..>>>>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>
>>>>>>>>>.>>....>.>>>.<<....>>...>>>>.......<<<<<<
<<.....>>>>>>>>.........>>>>.>....>>>.>>>>>...>>>>
...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<
<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<
<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[..>>>
..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>.
...>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<
....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<.......
.>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>..
.>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......
.....................<<.<<<<<<<<<...<<<....<<<....
<<<...<<<<<.<.....>.>>>>>.>>>....>>>..>>.>...>>>>>
>>...<<<<<<<<<.........>>>>>>>>>...>>.>>.>>>>>>>..
>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<
<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<
<<<<<<<.......<<<<<.<<....<<.........>>....>>.....
....<<......>>...>>>>>...>>>>>>>>>>>>>..........))
).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........].
.))).......................<<<.<.<<<.<<<<<<.<<.<<<
<<..<<>>.>>>>>.>>.>>>>>>.>>>..>.>>>...............
........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<
<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<...
..<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<
<<<<...<<.....>>.>>>>>>....(.<<<<<<...<<....<<<...
.>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>..
..>>...<<<<<........>>>>>.)<<<<....<<<<...<<<<<<<<
....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<
<<.<<<<<<<<<<..{{{..>>>>>>.....<<<<.<<<<.<<<<.....
<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<<.......
>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>.....
.....>..>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.
....>>>>..>>>....<<<<.....<<<<<<<.<<..............
.<<<<<...............>>>>><<.<<<<<<<<<<<...<<<<<<.
..<<<<<<<....<<<<<<..<<<<.<<.<<<<<<.<<<<<>>>>>.>>>
>.>>>>.>>>>.>>>>>>....>>>>>>>.....<<<<<<<<<<<<<.<<
<<>>>>.....>>>>>>>>>.>>>>.>>>>>>........>>>>>..>>>
>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<
<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<
<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<
<.......>>>>>>........<...........<<<<<.......>>>>
>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>
>....>>....<<<<<........>>>>>....[[[[[..{{{.{{....
..[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..
........<<<<<...<<<<...<<.<<.<<<<<<...<<<<....>>>>
.>>>>>>.>>.<<<....>>>...>>>>>>.............>>>>>.>
>>>.>>.>>>>>>>>>>...<<<<<.....<<<<...<.<<<<<<....>
>>>>>>...............<<<<<<<<<<<.....>>>>>>>>>>>..
>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<
<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......
>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<......
.>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>
>>>.)))))))))..........]]]]..}}]]]].......<<.<...<
<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.
<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>
.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}
}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<...........
......>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..
>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>..
.>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<...
.......<<<<<..<<<<<...<<<<<<<<<<<<<<<<<<<...<<..<<
<<.<>>>>>>>.>>>.>.>>>>>>>.>>>..>>>>>>>>>>.>>>>>...
.....>.........<<<<....<<<<.<<<<<<<......>>>>>>>>>
>>...>>>>....................>>>..>>>>>>>>><<<<<.<
.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.
.....>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>...

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v6x Structures of the human and Drosophila 80S ribosome.
• Resolution: 5.0 Å
• Binding residue (original residue number in PDB): M1 A2 K13 G14 H15 H26 S27 R30 G31 R32 L33 T34 H36 T37 R41 K67 R68 R76 V77 G78 R82 K86
• Binding residue (residue number reindexed from 1): M1 A2 K13 G14 H15 H26 S27 R30 G31 R32 L33 T34 H36 T37 R41 K67 R68 R76 V77 G78 R82 K86

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v6x, PDBe:4v6x, PDBj:4v6x
• PDBsum: 4v6x
• PubMed: 23636399
• UniProt: Q9Y3U8|RL36_HUMAN Large ribosomal subunit protein eL36 (Gene Name=RPL36)