Structure of PDB 6xu8 Chain Cg Binding Site BS01

Receptor Information

>6xu8 Chain Cg (length=103) Species: 7227 (Drosophila melanogaster)

VQRLTLRRRLSYNTRSNKRRIVRTPGGRLVYQYVKKNPTVPRCGQCKEKL
KGITPSRPSERPRMSKRLKTVSRTYGGVLCHSCLRERIVRAFLIEEQKIV
KAL

Ligand information

>6xu8 Chain A5 (length=3703)

uuauauacaaccucaacucauaugggacuacccccugaauuuaagcauau
uaauuaggggaggaaaagaaacuaacaaggauuuucuuaguagcggcgag
cgaaaagaaaacaguucagcacuaagucacuuugucuauauggcaaaugu
gagaugcaguguauggagcgucaauauucuaguaugagaaauuaacgauu
uaaguccuucuuaaaugaggccauuuacccauagagggugccaggcccgu
auaacguuaaugauuacuagaugauguuuccaaagagucguguugcuuga
uagugcagcacuaagugggugguaaacuccaucuaaaacuaaauauaacc
augagaccgauaguaaacaaguaccgugagggaaaguugaaaagaacucu
gaauagagaguuaaacaguacgugaaacugcuuagagguuaagcccgaug
aaccugaauauccguuauggaaaauucaucauuaaaauuguaauauuuaa
auaauauuaugagaauagugugcauuuuuuccauauaaggacauuguaau
cuauuagcauauaccaaauuuaucauaaaauauaacuuauaguuuauucc
aauuaaauugcuugcauuuuaacacagaauaaauguuauuaauuugauaa
agugcugauagauuuauaugauuacagugcguuaauuuuucggaauuaua
uaauggcauaauuaucauugauuuuuguguuuauuauaugcacuuguaug
auuaacaaugcgaaagauucaggauaccuucgggacccgucuugaaacac
ggaccaaggagucuaacauaugugcaaguuauugggauauaaaccuaaua
gcguaauuaacuugacuaauaaugggauuaguuuuuuagcuauuuauagc
uaauuaacacaaucccggggcguucuauauaguuauguauaauguauauu
uauauuauuuaugccucuaacuggaacguaccuugagcauauaugcugug
acccgaaagauggugaacuauacuugaucagguugaagucaggggaaacc
cugauggaagaccgaaacaguucugacgugcaaaucgauugucagaauug
aguauaggggcgaaagaccaaucgaaccaucuaguagcugguuccuuccg
aaguuucccucaggauagcuggugcauauauuauauaaaauaaucuuauc
ugguaaagcgaaugauuagaggccuuagggucgaaacgaucuuaaccuau
ucucaaacuuuaaauggguaagaaccuuaacuuucuugauaugaagauca
agguuaugauauaaaugucccagugggccacuuuugguaagcagaacugg
cgcugugggaugaaccaaacguaauguuacgugcccaaauuaacaacuca
ugcagauaccaugaaaggcguugguugcuuaaaacagcaggacggugauc
auggaagucgaaauccgcuaaggaguguguaacaacucaccugccgaagc
aacuagcccuuaaaauggauggcgcuuaaguuguauaccuauacauuacc
gcuaaaguagaugauuuauauuacuugugauauaaauuuugaaacuuuag
ugaguaggaagguacaaugguaugcguagaaguguuuggcguaagccugc
auggagcugccauugguacagaucuugguggauaguagcaaauaaucgaa
ugagagccuuggaggacugaaguggagaaggguuucgugugaacaguggu
ugaucacgaguuagucgguccuaaguucaaggcgaaagcgaaaauuuuca
aguaaaacauaauuuugaacgaaagggaauacgguuccaauuccguaacc
uguugaguauccguuuguuauuaaauaugggccucgugcucauccuggca
acaggaacgaccauaaagaagccgucgagagauaucggaagaguuuucuu
uucuguuuuauagccguacuaccauggaagucuuucgcagagagauaugg
uagaugggcuagaagagcaugacauauacuguugugucgauauuuucucc
ucggaccuugaaaauuuaugguggggacacgcaaacuucucaacaggccg
uaccaauauccgcagcuggucuccaaggugaagagucucuagucgauaga
auaauguagguaagggaagucggcaaauuagauccguaacuucgggauaa
ggauuggcucugaagauugagauagucggccuugauugggaaacuggaac
uuucuugcuaaauuauaacgauuaucaauuaacaaucaauucagaacugg
cacggacuuggggaauccgacugucuaauuaaaacaaagcauugugaugg
cccuagcggguguugacacaaugugauuucugcccagugcucugaauguc
aaagugaagaaauucaaguaagcgcgggucaacggcgggaguaacuauga
cucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcauga
auggauuaacgagauuccuacugucccuaucuacuaucuagcgaaaccac
agccaagggaacgggcuuggaauaauuagcggggaaagaagacccuuuug
agcuugacucuaaucuggcaguguaaggagacauaagagguguagaauaa
gugggagauauuagaccucgguuugguaucgucaaugaaauaccacuacu
cuuauuguuuccuuacuuacuugauuaaauggaacguguaucauuuccua
gauuggguuuugaugcaagcuucuugaucaaaguaucacgaguuuguuau
auaaucgcaaacaaauuugguauaacuccaauuacucagguaugauccaa
uucaaggacauugccagguagggaguuugacuggggcgguacaucucuca
aauaauaacggaggugucccaaggccagcucagugcggacagaaaccaca
cauagagcaaaagggcaaaugcugacuugaucucgguguucaguacacac
agggacagcaaaagcucggccuaucgauccuuuugguuuaaagaguuuuu
aacaagaggugucagaaaaguuaccauagggauaacuggcuuguggcggc
caagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuucc
uaucauugugaagcaaaauucaccaagcguuggauuguucacccaugcaa
gggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccu
acuaaugacaaaacguuguugcgacagcauuccugcguaguacgagagga
acccgcagguacggaccaauggcacaauacuuguucgagcgaacaguggu
augacgcuacguccguuggauuaugccugaacgccucuaaggucguaucc
gugcuggacugcaaugauaaauaaggggcaauuugcauuguauggcuucu
aaaccauuuaaaguuuauaauuuacuuuauaaacgacaauggaugugaug
ccaauguaauuuguaacauaguaaauugggaggaucuucgaucaccugau
gccgcgcuaguuacauauaaaagcauuauuuaauacaaugacaaagccua
gaaucaauuguaaacgacuuuuguaacaggcaagguguuguaagugguug
agcagcugccauacugcgauccacugaagcuuauccuuugcuugaugauu
cga

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>><<<<<<.....<<.<<<<<<<<<..<<<...<<<.......>>>...>
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>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>
>>...>>>>>>>>>>........>>>>>><<......<<......<<.<<
........>>.>>.<<<<<....<<<<<.<<...<<<<<....<<.....
>>..>>>>>....((<<<<<<...<<<<...<<....>>..........<
............>...>>>>....>>>..<<<<<........>>>>>))<
<<<<<<<.....................<<........>>....<<<...
.>>>......<<<<<<<....<<<..<<<<<...<.<<.<<<<..{{{..
>>>>.><...<<<<<...<<<<<<<<....<<<.....>>>....>>>>>
>>>...>>>>>.....><<<<<<.......>>>>>>>.>...>..>>>>.
.>>>..........>>>>>>>.................>>>>>>>>.>>>
..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<
.....<<<<<<<.<<...............<<<<<...............
>>>>><<.<<<<<<<<<.........<<......................
..................>>..............>>>..>>>>>>.>>..
..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<
<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.
..<.<<<<....>>>>..>..>>>.>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<.......>>>>>.....>..
...>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>..
..<<<<<........>>>>>....[[[[[..{{{.........{{{..{{
[[[[..<<<<<.<<<<<<<<..<<<<<<....<..<<<............
.<<<....<<<<<<<<....>>>>>>>>..............>>>....>
>>..>.....>>>>>>...<<<<<.....<<<<...<<<<.....<....
.....>.......>>>>...............<<<<<.............
......................................>>>>>..>>>>.
.>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<..
.........>>>>>>..<<...<<.<<<<...<<<.<<.......>>.>>
>.....<<...(((>>....>>>>.>>...<<<<.<<<<.......>>>>
.>>>>.<.<....>.>.>>))).......((((((..((((.>>>>>>))
))))))))..........]]]]..}}.}}}.......<<.<...<<<<<<
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<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....
>>>>>.>...>>>.>>....<<<<<<<....>>>.>>>>........}}}
.]]]]]........<<<<<<<<..<<<<.<.<<<<<<.............
...>>>>>>.><<<<<....<<<...<<<<<<<<<.}}}..>>>>..>>>
>>...>>>..>>>>>.<<<<....<<<<...........>>>>....>>>
>.>>>>....>>>>>>>>.......<<<<....<<<<<<<<.........
.............<<<<<<<......>>>>>>>.................
............<<<<<....<............................
.....>...>>>>>....................>>>>>>.>>..>>>>.
<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<...
.<..............>...>>>>...>>>....>>>>.>>>>>..>>>>
>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xu8 Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): V2 R4 L5 T6 L7 R8 R9 R10 L11 S12 Y13 T15 R16 S17 R20 R21 R24 T25 P26 G27 L30 Y32 Q33 K36 K37 N38 P42 R43 K52 G53 P56 R58 P59 S60 R62 P63 R64 S66 K67 R68 K70 T71 V72 S73 R74 T75 Y76 G78 V79 H82 R91 A92 I95 E96 K102
• Binding residue (residue number reindexed from 1): V1 R3 L4 T5 L6 R7 R8 R9 L10 S11 Y12 T14 R15 S16 R19 R20 R23 T24 P25 G26 L29 Y31 Q32 K35 K36 N37 P41 R42 K51 G52 P55 R57 P58 S59 R61 P62 R63 S65 K66 R67 K69 T70 V71 S72 R73 T74 Y75 G77 V78 H81 R90 A91 I94 E95 K101

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6xu8, PDBe:6xu8, PDBj:6xu8
• PDBsum: 6xu8
• PubMed: 34283226
• UniProt: Q9VHE5