Structure of PDB 6xu6 Chain Cg Binding Site BS01

Receptor Information

>6xu6 Chain Cg (length=103) Species: 7227 (Drosophila melanogaster)

VQRLTLRRRLSYNTRSNKRRIVRTPGGRLVYQYVKKNPTVPRCGQCKEKL
KGITPSRPSERPRMSKRLKTVSRTYGGVLCHSCLRERIVRAFLIEEQKIV
KAL

Ligand information

>6xu6 Chain A5 (length=3707)

uuauauacaaccucaacucauaugggacuacccccugaauuuaagcauau
uaauuaggggaggaaaagaaacuaacaaggauuuucuuaguagcggcgag
cgaaaagaaaacaguucagcacuaagucacuuugucuauauggcaaaugu
gagaugcaguguauggagcgucaauauucuaguaugagaaauuaacgauu
uaaguccuucuuaaaugaggccauuuacccauagagggugccaggcccgu
auaacguuaaugauuacuagaugauguuuccaaagagucguguugcuuga
uagugcagcacuaagugggugguaaacuccaucuaaaacuaaauauaacc
augagaccgauaguaaacaaguaccgugagggaaaguugaaaagaacucu
gaauagagaguuaaacaguacgugaaacugcuuagagguuaagcccgaug
aaccugaauauccguuauggaaaauucaucauuaaaauuguaauauuuaa
auaauauuaugagaauagugugcauuuuuuccauauaaggacauuguaau
cuauuagcauauaccaaauuuaucauaaaauauaacuuauaguuuauucc
aauuaaauugcuugcauuuuaacacagaauaaauguuauuaauuugauaa
agugcugauagauuuauaugauuacagugcguuaauuuuucggaauuaua
uaauggcauaauuaucauugauuuuuguguuuauuauaugcacuuguaug
auuaacaaugcgaaagauucaggauaccuucgggacccgucuugaaacac
ggaccaaggagucuaacauaugugcaaguuauugggauauaaaccuaaua
gcguaauuaacuugacuaauaaugggauuaguuuuuuagcuauuuauagc
uaauuaacacaaucccggggcguucuauauaguuauguauaauguauauu
uauauuauuuaugccucuaacuggaacguaccuugagcauauaugcugug
acccgaaagauggugaacuauacuugaucagguugaagucaggggaaacc
cugauggaagaccgaaacaguucugacgugcaaaucgauugucagaauug
aguauaggggcgaaagaccaaucgaaccaucuaguagcugguuccuuccg
aaguuucccucaggauagcuggugcauuuuaauauuauauaaaauaaucu
uaucugguaaagcgaaugauuagaggccuuagggucgaaacgaucuuaac
cuauucucaaacuuuaaauggguaagaaccuuaacuuucuugauaugaag
aucaagguuaugauauaaaugucccagugggccacuuuugguaagcagaa
cuggcgcugugggaugaaccaaacguaauguuacgugcccaaauuaacaa
cucaugcagauaccaugaaaggcguugguugcuuaaaacagcaggacggu
gaucauggaagucgaaauccgcuaaggaguguguaacaacucaccugccg
aagcaacuagcccuuaaaauggauggcgcuuaaguuguauaccuauacau
uaccgcuaaaguagaugauuuauauuacuugugauauaaauuuugaaacu
uuagugaguaggaagguacaaugguaugcguagaaguguuuggcguaagc
cugcauggagcugccauugguacagaucuugguggauaguagcaaauaau
cgaaugagagccuuggaggacugaaguggagaaggguuucgugugaacag
ugguugaucacgaguuagucgguccuaaguucaaggcgaaagcgaaaauu
uucaaguaaaacauaauuuugaacgaaagggaauacgguuccaauuccgu
aaccuguugaguauccguuuguuauuaaauaugggccucgugcucauccu
ggcaacaggaacgaccauaaagaagccgucgagagauaucggaagaguuu
ucuuuucuguuuuauagccguacuaccauggaagucuuucgcagagagau
augguagaugggcuagaagagcaugacauauacuguugugucgauauuuu
cuccucggaccuugaaaauuuaugguggggacacgcaaacuucucaacag
gccguaccaauauccgcagcuggucuccaaggugaagagucucuagucga
uagaauaauguagguaagggaagucggcaaauuagauccguaacuucggg
auaaggauuggcucugaagauugagauagucggccuugauugggaaacug
gaacuuucuugcuaaauuauaacgauuaucaauuaacaaucaauucagaa
cuggcacggacuuggggaauccgacugucuaauuaaaacaaagcauugug
auggcccuagcggguguugacacaaugugauuucugcccagugcucugaa
ugucaaagugaagaaauucaaguaagcgcgggucaacggcgggaguaacu
augacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgc
augaauggauuaacgagauuccuacugucccuaucuacuaucuagcgaaa
ccacagccaagggaacgggcuuggaauaauuagcggggaaagaagacccu
uuugagcuugacucuaaucuggcaguguaaggagacauaagagguguaga
auaagugggagauauuagaccucgguuugguaucgucaaugaaauaccac
uacucuuauuguuuccuuacuuacuugauuaaauggaacguguaucauuu
ccuagauuggguuuugaugcaagcuucuugaucaaaguaucacgaguuug
uuauauaaucgcaaacaaauuugguauaacuccaauuacucagguaugau
ccaauucaaggacauugccagguagggaguuugacuggggcgguacaucu
cucaaauaauaacggaggugucccaaggccagcucagugcggacagaaac
cacacauagagcaaaagggcaaaugcugacuugaucucgguguucaguac
acacagggacagcaaaagcucggccuaucgauccuuuugguuuaaagagu
uuuuaacaagaggugucagaaaaguuaccauagggauaacuggcuugugg
cggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcuc
uuccuaucauugugaagcaaaauucaccaagcguuggauuguucacccau
gcaagggaacgugagcuggguuuagaccgucgugagacagguuaguuuua
cccuacuaaugacaaaacguuguugcgacagcauuccugcguaguacgag
aggaacccgcagguacggaccaauggcacaauacuuguucgagcgaacag
ugguaugacgcuacguccguuggauuaugccugaacgccucuaaggucgu
auccgugcuggacugcaaugauaaauaaggggcaauuugcauuguauggc
uucuaaaccauuuaaaguuuauaauuuacuuuauaaacgacaauggaugu
gaugccaauguaauuuguaacauaguaaauugggaggaucuucgaucacc
ugaugccgcgcuaguuacauauaaaagcauuauuuaauacaaugacaaag
ccuagaaucaauuguaaacgacuuuuguaacaggcaagguguuguaagug
guugagcagcugccauacugcgauccacugaagcuuauccuuugcuugau
gauucga

..............................<<<........<......>.
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....>>>>>>>...>>>>>>>.......>..........<<<<<<<....
....>>>>>>>.....<<<<<..((((((>>>>>..>>>...........
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<<<<<....<<<....<<<....<<<.....<.<<.......>>.>...>
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.>>>>....<<<......>>>...<<<<<<<.<.<<(((.......<<<<
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>.>>>>...>>.>>>>>>>........>>>>>><<......<<......<
<.<<........>>.>>.<<<<.....<<<<<.<<...<<<<<....<<.
....>>..>>>>>....((<<<<<<...<<<....<<....>>.......
.....................>>>....>>...<<<<<........>>>>
>))<<<<<<<<.......<<......>>....<<........>>....<<
<....>>>......<<<<<<<....<<<..<<<<.<..<..<.<<<<...
[[..>>>>.><...<<<<<...<<<<<<<<....<<<.....>>>....>
>>>>>>>...>>>>>.....><<<<<<<.....>>>>>>>..>...>..>
>>>..>>>..........>>>>>>>.................>>>>>>>>
>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..
<<<<.....<<<<<<<.<<.........<.....<<<<<...........
....>>>>><<.<<<<<<<<<<....<.<.<...................
......(................>)>.>.........>>>>..>>>>>>.
>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<....
.<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<....
...>>>>>>........<...........<<<<<.......>>>>>....
.>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....
>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<
..<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<.................
......<<....<<<<<<<<....>>>>>>>>..............>>..
............>.>>>>>>...<<<<<.....<<<<...<<<<<.....
................>>>>>...............<<<<...<<.....
.................<..>..................>>..>>>>..>
>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<
<<...........>>>>>>..<<...<<.<<<<...<<<.<<.......>
>.>>>.....<<...(((>>....>>>>.>>...<<<<.<<<<.......
>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))
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....>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>.
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.......>>>>>>.><<<<<....<<<...<<<<<<<<..]]....>>>.
.>>>>>...>>>..>>>>>.<<<.....<<<<...........>>>>...
..>>>.>>>>....>>>>>>>>.......<<<<....<<<<<<<<<....
................<<<<<<<<......>>>>>>>>............
...............<<<<<<....<..<<<<<<..............>>
>>>>.....>...>>>>>>..................>>>>>>>.>>..>
>>>.<<<<<.<.............>.....<<<<<<<<<.<<<....<<<
<....<.<<........>>.>...>>>>...>>>....>>>>.>>>>>..
>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xu6 Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): V2 R4 L5 T6 R8 R9 R10 L11 S12 Y13 N14 T15 K19 R20 R21 R24 T25 P26 G27 R29 K37 N38 P42 R43 K48 K52 G53 P56 R58 P59 S60 R62 P63 S66 K67 R68 K70 T71 S73 R74 T75 Y76 G78 V79 H82 R88 R91 A92 I95 E96 Q98
• Binding residue (residue number reindexed from 1): V1 R3 L4 T5 R7 R8 R9 L10 S11 Y12 N13 T14 K18 R19 R20 R23 T24 P25 G26 R28 K36 N37 P41 R42 K47 K51 G52 P55 R57 P58 S59 R61 P62 S65 K66 R67 K69 T70 S72 R73 T74 Y75 G77 V78 H81 R87 R90 A91 I94 E95 Q97

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6xu6, PDBe:6xu6, PDBj:6xu6
• PDBsum: 6xu6
• PubMed: 34283226
• UniProt: Q9VHE5