Structure of PDB 6sg9 Chain Cg Binding Site BS01

Receptor Information
>6sg9 Chain Cg (length=484) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKSLAAMYMRPPVTCYTDACEAPVAMWDGAIPLKETRKLKNGVPVRTVSR
TYSHPPQLTPTQLSFNDINSMYCVGNDELIQFFPEGLGGRVFQTMPPGHP
RGFLYRKETHLLNLFVDKVQHWHTKRSVLSSLTNGRTGFIVDGPTGCGKS
ALMCQVVHFARSRNIVTLYVPDAKVWTHGEWCWPSTILPGFFDAPDAARS
FLKYFAVANRATLTSWKLRCTPKDLPTEQGERQPQNLYELCEWGHRAVAP
ASIDRQSVCVKFLMDELSEEKKLPVVIVVDGWNLFSHETHFRYPHPDFLR
GLASFNESSTDIDLYPQELPRIPASRLSFVRGLNKMILSGDDPNKFFITC
TTRDFKPFDGISGFPNVETDRFANSLDEYAPYDPEKDSHFHPIQIGNFDE
YEYRSFLRFLINSGELAGLGWGPLWHASSDFERKLYKIGFLSGRNPQGVV
DHYHQELVWRYDYQRTRQKQYLLKRRMEGMSRGA
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain6sg9 Chain CgA Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6sg9 Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R96 Q99 G108 F109 L110 T151 G152 C153 K155 S156 A157 T358 R359 D360 P452
Binding residue
(residue number reindexed from 1)		R90 Q93 G102 F103 L104 T145 G146 C147 K149 S150 A151 T352 R353 D354 P446
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0031981 nuclear lumen
GO:0097014 ciliary plasm
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6sg9, PDBe:6sg9, PDBj:6sg9
PDBsum6sg9
PubMed31515389
UniProtQ585C2

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