Structure of PDB 6xu7 Chain Cf Binding Site BS01

Receptor Information

>6xu7 Chain Cf (length=157) Species: 7227 (Drosophila melanogaster)

MADTQAKSTTAPKAAKAQKAPKAVKAPKAEKPAASEAKVSAKKYKRHGRL
FAKAVFTGYKRGLRNQHENQAILKIEGARRKEHGSFYVGKRCVYVYKAET
KKCVPQHPERKTRVRAVWGKVTRIHGNTGAVRARFNRNLPGHAMGHRIRI
MLYPSRI

Ligand information

>6xu7 Chain A5 (length=3707)

uuauauacaaccucaacucauaugggacuacccccugaauuuaagcauau
uaauuaggggaggaaaagaaacuaacaaggauuuucuuaguagcggcgag
cgaaaagaaaacaguucagcacuaagucacuuugucuauauggcaaaugu
gagaugcaguguauggagcgucaauauucuaguaugagaaauuaacgauu
uaaguccuucuuaaaugaggccauuuacccauagagggugccaggcccgu
auaacguuaaugauuacuagaugauguuuccaaagagucguguugcuuga
uagugcagcacuaagugggugguaaacuccaucuaaaacuaaauauaacc
augagaccgauaguaaacaaguaccgugagggaaaguugaaaagaacucu
gaauagagaguuaaacaguacgugaaacugcuuagagguuaagcccgaug
aaccugaauauccguuauggaaaauucaucauuaaaauuguaauauuuaa
auaauauuaugagaauagugugcauuuuuuccauauaaggacauuguaau
cuauuagcauauaccaaauuuaucauaaaauauaacuuauaguuuauucc
aauuaaauugcuugcauuuuaacacagaauaaauguuauuaauuugauaa
agugcugauagauuuauaugauuacagugcguuaauuuuucggaauuaua
uaauggcauaauuaucauugauuuuuguguuuauuauaugcacuuguaug
auuaacaaugcgaaagauucaggauaccuucgggacccgucuugaaacac
ggaccaaggagucuaacauaugugcaaguuauugggauauaaaccuaaua
gcguaauuaacuugacuaauaaugggauuaguuuuuuagcuauuuauagc
uaauuaacacaaucccggggcguucuauauaguuauguauaauguauauu
uauauuauuuaugccucuaacuggaacguaccuugagcauauaugcugug
acccgaaagauggugaacuauacuugaucagguugaagucaggggaaacc
cugauggaagaccgaaacaguucugacgugcaaaucgauugucagaauug
aguauaggggcgaaagaccaaucgaaccaucuaguagcugguuccuuccg
aaguuucccucaggauagcuggugcauuuuaauauuauauaaaauaaucu
uaucugguaaagcgaaugauuagaggccuuagggucgaaacgaucuuaac
cuauucucaaacuuuaaauggguaagaaccuuaacuuucuugauaugaag
aucaagguuaugauauaaaugucccagugggccacuuuugguaagcagaa
cuggcgcugugggaugaaccaaacguaauguuacgugcccaaauuaacaa
cucaugcagauaccaugaaaggcguugguugcuuaaaacagcaggacggu
gaucauggaagucgaaauccgcuaaggaguguguaacaacucaccugccg
aagcaacuagcccuuaaaauggauggcgcuuaaguuguauaccuauacau
uaccgcuaaaguagaugauuuauauuacuugugauauaaauuuugaaacu
uuagugaguaggaagguacaaugguaugcguagaaguguuuggcguaagc
cugcauggagcugccauugguacagaucuugguggauaguagcaaauaau
cgaaugagagccuuggaggacugaaguggagaaggguuucgugugaacag
ugguugaucacgaguuagucgguccuaaguucaaggcgaaagcgaaaauu
uucaaguaaaacauaauuuugaacgaaagggaauacgguuccaauuccgu
aaccuguugaguauccguuuguuauuaaauaugggccucgugcucauccu
ggcaacaggaacgaccauaaagaagccgucgagagauaucggaagaguuu
ucuuuucuguuuuauagccguacuaccauggaagucuuucgcagagagau
augguagaugggcuagaagagcaugacauauacuguugugucgauauuuu
cuccucggaccuugaaaauuuaugguggggacacgcaaacuucucaacag
gccguaccaauauccgcagcuggucuccaaggugaagagucucuagucga
uagaauaauguagguaagggaagucggcaaauuagauccguaacuucggg
auaaggauuggcucugaagauugagauagucggccuugauugggaaacug
gaacuuucuugcuaaauuauaacgauuaucaauuaacaaucaauucagaa
cuggcacggacuuggggaauccgacugucuaauuaaaacaaagcauugug
auggcccuagcggguguugacacaaugugauuucugcccagugcucugaa
ugucaaagugaagaaauucaaguaagcgcgggucaacggcgggaguaacu
augacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgc
augaauggauuaacgagauuccuacugucccuaucuacuaucuagcgaaa
ccacagccaagggaacgggcuuggaauaauuagcggggaaagaagacccu
uuugagcuugacucuaaucuggcaguguaaggagacauaagagguguaga
auaagugggagauauuagaccucgguuugguaucgucaaugaaauaccac
uacucuuauuguuuccuuacuuacuugauuaaauggaacguguaucauuu
ccuagauuggguuuugaugcaagcuucuugaucaaaguaucacgaguuug
uuauauaaucgcaaacaaauuugguauaacuccaauuacucagguaugau
ccaauucaaggacauugccagguagggaguuugacuggggcgguacaucu
cucaaauaauaacggaggugucccaaggccagcucagugcggacagaaac
cacacauagagcaaaagggcaaaugcugacuugaucucgguguucaguac
acacagggacagcaaaagcucggccuaucgauccuuuugguuuaaagagu
uuuuaacaagaggugucagaaaaguuaccauagggauaacuggcuugugg
cggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcuc
uuccuaucauugugaagcaaaauucaccaagcguuggauuguucacccau
gcaagggaacgugagcuggguuuagaccgucgugagacagguuaguuuua
cccuacuaaugacaaaacguuguugcgacagcauuccugcguaguacgag
aggaacccgcagguacggaccaauggcacaauacuuguucgagcgaacag
ugguaugacgcuacguccguuggauuaugccugaacgccucuaaggucgu
auccgugcuggacugcaaugauaaauaaggggcaauuugcauuguauggc
uucuaaaccauuuaaaguuuauaauuuacuuuauaaacgacaauggaugu
gaugccaauguaauuuguaacauaguaaauugggaggaucuucgaucacc
ugaugccgcgcuaguuacauauaaaagcauuauuuaauacaaugacaaag
ccuagaaucaauuguaaacgacuuuuguaacaggcaagguguuguaagug
guugagcagcugccauacugcgauccacugaagcuuauccuuugcuugau
gauucga

...............................<<.................
........>>...........<<....>>...<<<<<.....<<.....>
>....>>>>>...<<<..........<<<<<<<<<<.....>>>>>>.>>
>>...............<.........<<<<<<<......<<<<<<<..<
.....<<<<.......>>>>.......((......<<<.....))>>>..
>...>>>>>>>...>>>>>>>.......>..........<<<<<<<....
....>>>>>>>.....<<<<<..((((((>>>>>..>>>...........
.......................<<....>>...............<<<<
....>>>>...................................<<<<<..
..<<<<<........<<.<<<<<<......<<<<...<<<<<<<<<....
...>>>>>>>>.>..>>>>.......>>>>>>.>>......<<<<<<..<
<<<<<<<..<.<<..<<....<<..<....<<<.......<<..<.....
.............>..>>..........>>>...>..>>....>>..>>.
>...>>>>>>>>..............<.<.......<.....>.......
<.<<<<<<<.<..<<.....>>.>..>>>>.>>>.>....>..>......
....>>>>>>........>>>>>......>>>>>..<<<<........>>
>><<<<<<.....<<.<<<<<<<<<..<<<...<<<.......>>>...>
>>......................<<<.<.<<<..<<<<<<......>>>
>>>..>>>..>.>>>.<<<<<<<<<<....<<<<<..<............
............>....>>>>>>>>>>>>.>>>...>>>>>>>>>.>>..
.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>
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>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<.
...<.<<<....>>>.><<<.<<<..<.................<<.<.<
<<<<<.....<<....<<.....<<<.....<.<<.......>>.>...>
>>.....>>..>>......>>>>>>...<.<.<.<<<..........>>>
.>.>.>.....>.>>..>.>>>...>>>..<<<<.<<<<<.....>>>>>
.>>>>....<<<......>>>...<<<<<<<...<<<<............
........(..........<<<.<<<<<<<<<<........<<<<.<<..
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.>>>>>>>>>>>>>...........>>.)...........>>....>>>>
>>>.<<<<<<<<....<<<<<<<<<<......>>>>>>>>>>.....>>>
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>.>>>>...>>.>>>>>>>..>.....>>>>>><<......<.......<
<.<<........>>.>>.<<<<<....<<<<<.<<...<<<<<..<.<<.
....>>.>>>>>>....((<<<<<<...<<.....<<....>>.......
......................>>....>>....<<<..........>>>
.))<<<<<<<<.......<<......>>....<<........>>....<<
<....>>>......<<<<<<<....<<<..<<<<.<<<.....<<<<..[
[[..>>>>......<<<<<...<<<<<<<<....<<<.....>>>....>
>>>>>>>...>>>>>......<<<<<<<.....>>>>>>>....>>>..>
>>>..>>>..........>>>>>>>.................>>>>>>>>
>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..
<<<......<<<<<<<.<.<..............<<<<<...........
....>>>>><<.<<<<<.<<<<......<.....................
......<.................>>...........>>>>...>>>>>.
>>............<<<<<<<....<<<.........>>>..<<<<<<<.
...<<<<....>>>>......>>>>>>>....<..<<<..<<<<<.....
..<.....<<<<....>>>>.....>....>>>..>>>>><<<<<<....
...>>>>>>........<...........<<<<<.......>>>>>....
.>.....>........>>>>>>>.....>>.>>>>>>.>..>>>.>....
>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<
..<.<<<<..<<<<...<<<<<<<..<<<<<<..................
......<<....<<<<<<<<....>>>>>>>>..............>>..
..............>>>>>>...<<<<<.....<<<<...<<<<<.....
................>>>>>...............<<<<...<<.....
.................<..>..................>>..>>>>..>
>>>..>>>>>.....>>>>>>>....>>>>....<<.....>>....<<<
<<...........>>>>>...<<...<<.<<<<...<<<.<<.......>
>.>>>.....<<...(((>>....>>>>.>>...<<<<.<<<<.......
>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))
))>>>>>>>>>>>.........>>>>...>.>>>.......<<.<.<..<
<<<<...<<.......>>...>>>>>....>>.>.>.........<<<..
.<<<...<.<.<<<<<......>>>>>...>.>.<<<.........>>>.
.....>>>......>>>.......<<<<<<<....>>>.>>>>....>>.
.>>>.>>>>>........<<<<<<<<..<<<<...<<<<<<.....<...
.>.....>>>>>>..<<<<<....<<<...<<<<.<<<..]]]...>>>.
..>>>>...>>>..>>>>>.<<<.....<<<<...........>>>>...
..>>>.>>>>....>>>>>>>>.......<<<....<<<<<<<<<<....
................<<<<<<<<......>>>>>>>>............
...............<<<<<<....<..<..<<<..<........>..>>
>..>.....>...>>>>>>..................>>>>>>>.>>>..
>>>.<<<<<.<.............>.....<<<<<<<<<.<<<....<<<
<....<.<<........>>.>...>>>>...>>>....>>>>.>>>>>..
>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xu7 Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching.
• Resolution: 4.9 Å
• Binding residue (original residue number in PDB): M1 A2 S40 A41 K42 R49 L50 F51 R61 N65 Q66 H67 E68 N69 R80 K81 R91 Y96 K97 A98 E99 T100 K102 C103 V104 Q106 H107 E109 R110 K111 T112 R113 V114 R115 A116 W118 K120 T122 R123 H125 G126 N127 T128 R132 R134 R137 N138 P140 G141 H142 M144 R147 M151 Y153 R156
• Binding residue (residue number reindexed from 1): M1 A2 S40 A41 K42 R49 L50 F51 R61 N65 Q66 H67 E68 N69 R80 K81 R91 Y96 K97 A98 E99 T100 K102 C103 V104 Q106 H107 E109 R110 K111 T112 R113 V114 R115 A116 W118 K120 T122 R123 H125 G126 N127 T128 R132 R134 R137 N138 P140 G141 H142 M144 R147 M151 Y153 R156

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042273 ribosomal large subunit biogenesis

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6xu7, PDBe:6xu7, PDBj:6xu7
• PDBsum: 6xu7
• PubMed: 34283226
• UniProt: Q9VNB9