Structure of PDB 6rxx Chain Cc Binding Site BS01

Receptor Information

>6rxx Chain Cc (length=192) Species: 209285 (Thermochaetoides thermophila)

YDVLPKEVLAEVGSVKLFNRWSYDDIEIRDISLTDYIQIRAPVYIPHSAG
RYAVKRFRKANCPIIERLTNSLMMHGRNNGKKLMAVRIVAHAFEIIHLMT
DQNPIQVAVDAIVNCGPREDSTRRQAVDVSPLRRVNQAIALLTTGAREAA
FRNVKTIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR

Ligand information

>6rxx Chain C1 (length=1221)

ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgggcucugugggugggggaauucaggag
gggaaaacgauaguuaccugguugauucugcuagucauaugcuugucuca
aauaagccaugcgucuaaguauaagcaauuauacagcgaaacugcgaaug
gcucauuaaaucaguuaucguuuauuugauaguaccuuacuacauggaua
accgugguaauucuagagcuaauacaugcugaaaaucccgacuucggaag
ggauguauuuauuagauuaaaaaccaaugcccuucggggcggugauucau
aauaacuucucgaaucgcacggccuuggccggcgaugguucauucaaauu
ucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaa
cggguaaggguuagggcucggagaaggagccugagaaacggcuacuacau
ccaaggaagggcaggcgcgcaaauuacccaaucccgacacggggagguag
ugacaauaaauacugauacagggcucuuucgggucuuguaauuggaauga
guacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugc
cagcagccgcgguaauuccagcuccaauagcguauauugcucguaguuga
accugggccuagcccgccgguccgccucaccgcgugcacuggcugggcug
ggccugauuaauagggacagucgggggcgucaguauucaauugucagagg
ugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaa
ggauguuuucauuaaucaggaacguaaacuauuagggaucggacggcguu
uauuuuugacccguucggcaccuuacgauaggaguauggucgcaaggcug
aaaaauugacggaagggcaccaccagggguggagccugcgcgcgcgcuac
acugacagagccagcgaguacucccuuggccgagaggcccggguaaucuu
guuaaacucugucgugcuggggauagagcauugcaauuauugcucuucaa
cgaggaaucccuaguaagcgcaagucaucagcuugcguugauuacguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauagaggaaguagguc
uccguaggugaaccugcggag

<<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>
>.>>>>............................................
.................................<<.<<<<<<...<.<<.
.....<<<.<<<<<....<<....<<.........>>...>>.>>.....
.<<<.......<<<..<<..<<....<<<...............<<..<.
.<..<<.......>>..>.....>>>........<<<<<..........>
>>>><...<<<<<<..............<<<<<..>>>>>.........>
>>>>>.....>...<<<<.<<<<....>>>>>>>>....>>>...>>>>.
.>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>.....
.>>>...<<<<....>>>>.>>>.<<.<<<<........>>>>.>>.<.<
<<..>>>.>.>>>>>>.........<<<...<<<<.....>>>.>>>>..
.>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....
<<..<...........>..>>.........<<<<<<.......<<<....
>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<
<...<<<<<<<<<<<<<<<<<.<<<......>>>...>>>>>>.>>>>>>
>>>>>..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<.
.....>>>......>.>>>>>>.>>>.......<<....>>...>>>>..
>>.>>>.>>>...>>>...>>.>...........<<..<<<<<<<<.<<<
.......>>>>>>>>>>>..>>............................
.......<<<<<<<<<<<<..<<.<<<<<<..<<<..........>>>..
...<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.
......>>>>>>>...........<<<<<<..........>>>>>>....
......>>>>>>....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>............>>>>>..<<<<.<<......>>.>>>>...<
<<<<<<<<....>>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rxx Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
• Resolution: 7.1 Å
• Binding residue (original residue number in PDB): A65 K67 N82 L84 N90 G92 L95 M96 N156 A170 F171 R172 N173 V174 K175 T176 I177
• Binding residue (residue number reindexed from 1): A53 K55 N70 L72 N78 G80 L83 M84 N136 A150 F151 R152 N153 V154 K155 T156 I157

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6rxx, PDBe:6rxx, PDBj:6rxx
• PDBsum: 6rxx
• PubMed: 31378463
• UniProt: G0S1Z0