Structure of PDB 8pv8 Chain Cb Binding Site BS01

Receptor Information
>8pv8 Chain Cb (length=101) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVFAKRTMTKTRRRLRDLDQIERDLRSPRHLQQYKETKAAEDLPGLGLYY
CIECAKWFESETSLVGHRKGKPHKRRLKQLKEGAYTHEEAMAAIGYRIDN
G
Ligand information
>8pv8 Chain C1 (length=3085) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaaguga
acguaggugagagcuucggcgcaucaucgaccgauccugauguauucgga
uggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuau
gcuuggauagggugaagccagaggaaacucugguggaggcucgcagcggu
ucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacuaa
ucgaaccaucuaguagcugguuaccgccgaaguuuccggauagcaguguc
gaccuucaguuuuaugagagcgaaugauuagggacucgggggcgccuuca
uccauucucuguaagaagcccuuguuacuuaacugaacgugggcgaaugu
cgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaa
ccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaa
aggcguuaguacaucuugacagcaggacgguggccauggaagucggaauc
cgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaa
uggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacg
augcccugaggaguaggcggccguggaggucagugacgaagccuagggcg
ugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaa
uacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaa
cagcgguuggacauggguuagucgauccuaagccauagggaaguuccguu
ucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauu
ccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagac
gacggcgggggccccgggcagaguucucuuuucuucuuaacggucuauca
cccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccg
acacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgg
gagggaauaauucucacgccaggucguacucauaaccgcagcaggucccc
aaggugaacagccucugguugauagaacaauguagauaagggaagucggc
aaaauagauccguaacuucgggaaaaggauuggcucuaaggguugguaac
aaccaacuuagaacugguacggacagggggaaucugacugucuaauuaaa
acauagcauugcgauggccagaaagugguguugacgcaaugugauuucgc
ccagugcucuaugucaaagugaagaaauucaaccaagcgcggguaaacgg
cgggaguaacuaugacucucuuaagguuaacgagauucccacugucccua
ucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucag
cggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaa
gacauaggagguguagaauaggugggagcuucggcgccagugaaauacca
cuacuccuauuguuuuuuuacuuauucaaugaagcggggcuggacuugcg
uccaacuucuggaguuaagguccuucgcgggccgacccggguugaagaca
uugucagguggggaguuugggcacaucugcagguguccuaaggggggcuc
auggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugau
uuugauuuuugugaauacaaaccaugaaaguguggccccuuuagucccuc
gaaauuugaggcuagaggaaguuaccacagggauggcuuguggcggccaa
gcguucauagcgacgucgcuuugauccuucgaugucggcucuuccuauca
uaccgaagcagaauucgguaagcguuggauuguacccacuaauagggaac
gagcuggguuuagaccgucgugagacagguuaguuuuacccuacugauga
acucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucag
auaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccau
cugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgc
gacgauacuacccgcacguuguagacguauaagaauaggcuccggccucg
uauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauu
cgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacu
uagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacga
ucugcugaggguaagcccuccuucgccuagauuuc
........................<<<<<<.....<......>......>
>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.((..
....<<<.....))>>>.>..>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<..(((((
(>>>>>..>>>....>.............................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<
<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>
>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<........>>>><<<<<<...<<<<
<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>..
.....<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>..
.>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<..<<<<<<<.....<<
<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.
<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>..
....>>>>>>...>..>.>>...<<<<<......<<..>>..<<<<<<<<
<.....<<.<<<<<<<.........<<....<<<...<<<<<..>>>>>.
>>>..>>..>>>>>...<<<<.<<<<.<......>>>>>.>>>>.>>>>.
>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......
>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........
<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>
>>.........<<......>>...>>>>>...>>>>>>>>>>>>>.....
.....))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.......
..>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<.
...>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<...
..<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...
<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>...
.....<<<<<<....>>>>>>....>>>....>>...<<<<<........
>>>>>))<<<<.<<<<.<<<....<<<....>>>...<.((<<<<<<...
<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<
<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<
<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.
..>.....>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>
.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........
......<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>
>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........
>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>......<<
<..<<<<<<..<<<.....<<<<....>>>>.....>>>.>>>>..>>>>
><<<<<<.......>>>>>>..........>>.>>>>>>>.....>>.>>
>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<
..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<
<<<<<<<<<<..........<<<<<..<<....>>............>>>
>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<....>
>>>>..........))..<<<<<.....>>>>>..>>>>..>>>>>....
.>>>>>>>>..>>>>>...<<.<<<<<<..>>>>>>>>...<<<<<<<..
.<<<<<<.......>>>>>>.....<<....((>>....>>>>>>>...<
<<.<<<<<....>>>>.>>>>.<<<....>>>...))<<<<<<<..<<<<
.))))))>>>>>>>>>>>.>>>>..>>>>>>>.........<<<<<<...
<<.......>>...>>>>>>...............<<<<...<<<<..<.
<<<<<<<......>>>>>>>...>.<<<.<...>.>>>.....>>>>...
..>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>..
..<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<
<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>
>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>
>>>>>.....<<<<<.<<.<<<......<<.......<<<....>>>...
.>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>
>>>..............>>>>>.>>>>>...<<<<<<<............
.>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>..
.>>>>...>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pv8 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.
Resolution2.91 Å
Binding residue
(original residue number in PDB)
G2 F4 A5 R7 T8 K11 T12 R13 F59 G67 H68 K72 R76 K79
Binding residue
(residue number reindexed from 1)
G1 F3 A4 R6 T7 K10 T11 R12 F58 G66 H67 K71 R75 K78
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8pv8, PDBe:8pv8, PDBj:8pv8
PDBsum8pv8
PubMed37921038
UniProtG0SB32

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