Structure of PDB 8ia0 Chain CZ Binding Site BS01

Receptor Information
>8ia0 Chain CZ (length=576) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LAEELARTKQLWETLREQRQKLIEELYSIITGRIKDFVLKHDAVRAVQTA
IKYATPTQRRQIAKELQGSYAQLAESRYAKFLIAKLLVQNDEEIRDMIIP
EFFGKVRKLINHPEASWILDDIYRTVATKQQKAQMLREWYGPEFALFKPE
KGAEATADLSKILAEEPSKRAPVLKYLFDMTNTLIQKKMTGFTMLHDAML
QYFLNLKPESEELKEFVEVIKGDEGGDLLKNLAFTKSGARLVCLLLAHGN
AKDRKQILKTYKDTFQLMCGDQYAHMVILTAYDVIDDTVMTAKTIFPELL
GRNEEKNLENIIFLANDLTARITVMYLFEGQAKSLFPASHAYDLELLAEI
HEIRKKTSKKDPEVRRKELVAAVSPPLLAAVAASPKDLVSTGFGCQFVAD
VLLAATGDKKAAMEAVASTAAGDPNAPPPEDADPVNLPLPHLSLTTHGGK
MLKTLIAGGRFDKEAGCVKRVDPPLNFADILYPVIKEHIVKWAIGPSSFT
VLGMLEAPDFSLKKELIKTLKAERKTLEAAANGELSSHEIKCENKPDGKK
KNKAKANGSEGKPIGNRGSKLILEKL
Ligand information
>8ia0 Chain C1 (length=2928) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagc
uucggcgcaucaucgaccgauccugauguauucggauggauuugaguagg
agcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggug
aagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaa
ucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccga
aguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcg
aaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggu
cgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaug
cgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucaga
caccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaa
gucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuag
cccugaaaauggauggcgcucaagcgucccacccauaccccgcccucagg
guagaaacgaugcccugaggaguaggcggccguggaggucagugacgaag
ccuagggcgugagcccgggucgaacggccucuagugcagaucuugguggu
aguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguu
ccaugugaacagcgguuggacauggguuagucgauccuaagccauaggga
aguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccg
guuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaa
cgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaac
ggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccgg
aagagcccgacacuucugucggguccggugcgcucucgacgucccuugaa
aauccgcgggagggaauaauucucacgccaggucguacucauaaccgcag
cagguccccaaggugaacagccucugguugauagaacaauguagauaagg
gaagucggcauccguaacuucgggaaaagggcucuaaggguugggcacgu
ugggcuuugggcggacgcccugggagcagagggccucuagccgggcaacc
ggccggcggcccucagcacccgggguugaagcccuuagcccggcgugcgg
uuaacaaccaacuuagaacugguacggacagggaaucugacgucuauagc
auugcgauggccagaaagugguguugacgcaaugugucugcccagugcuc
ugaaugucaaagugaagaaauucaaccaagcgcggguaaaaugccucguc
aucuaauuagugacgcgcauggauaacgagauucccacugucccuaucua
cuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggg
gaagacccuguugagcuugacucuaguuugacauugugaaaagacauagg
agguguagaauaggugggagcuucggcgccagugaaauaccacuacuccu
auuguuuuuuuacuuauucaaugugaagacauugucagguggggaguucc
uuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggaua
acuggcuuguggcggccaagcguagcgacgucgcuucggcucuuccuauc
auaccgaagcagaauucgguaagcguuggauuguucacccacuaauaggg
aaagcuggggaccgucgugagacagguuagucccuacugaugaacucguc
gcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauug
guuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcugg
auaauggcugaacgccucuaagucagaauccaugccagaacgcgacgaua
cuacccgcacguuguagacguauaagaauaggcuccggccucguauccua
gcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguau
ugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugu
gcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcug
aggguaagcccuccuucgccuagauuuc
........................<<<<<<.....<<....>>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>..................................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<
<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.....<.<<<<<<<<......<<<<<<..>>>>>>.......>>>
>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<....<<<
<<<<<.<<<<..<<<...<<<<.....>>>>...>>>....<<<<<..<<
....>>...>>>>>.<<<<<<<<..............>>>.>>>.>>...
.>>>>.>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<.
..<<<<<<<....>>>>>>>....>>>>..<<<<<........>>>>>..
>>>>>>>>>..<<.<....>.>>.>>>>>>......>.>>...<<<<<..
..<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<..
......>>.>.....>>>>>....<<<.<<<<.<......>>>>>.>>>.
..>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....
<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<.
.........<<<.<<<<<<<<<<.......<<<<<.<<<...<<......
...>>...>>>.........<<......>>...>>>>>...>>>>>>>>>
>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<
<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<
<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.
....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...
<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<.
...>>>........<<<<<......>>>>>....>>>....>>...<<<<
<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......
<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><...<
<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.
...><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.......
..>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<....
..>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<
.......<..<<<<<<.<.<<.................<<<<<.<<<<<.
.<.<<<..<<<<....<<<<<<<<.<<.<<<<<<<.<<.<<<<<....>>
>>>.>>.>>>>>>>.>>.>>>>>>>>....>>>>..>>>>...>>>>>..
....>>>>>......>>...>.>>>>>>..<<<<<<<<<..<<<<...<<
<<<<<....<<<<.....>>>>......>>>>>>>...<<<<<.<<<<<.
<<<<<.<<........>>.>>>>>....>>>>>>>>>>..<<<<..<<<<
<<.......>>>>>>.>>>>>>>>..>>.>>>>>>>.>...>>.>>>>>>
>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<
<....<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<
<<..........<<<<<..<<....>>............>>>>>.>>>>>
>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>>..>>>>>.<<
<<<<<..<<<<<.....>>>>>>>>>>>>....>>>>>.>.>>>>>>...
..........<<<<<<...<<...>>...>>>>>><<<<<<.<<<<<..<
.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>
>.>>>>>>.<<<<<<<....>>>.>>>>....>>>.>>>>>....<<<<<
<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<
<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<<
<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>..
...<<<<<.<<.<<<......<<.......<<<....>>>....>>....
....<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>....
..........>>>>>.>>>>>...<<<<<<<.............>>....
<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>..
.>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ia0 Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		K121 E125 L127 R128 R138 R164 Y172 P232 K306 C514 H566 K569 M570
Binding residue
(residue number reindexed from 1)		K9 E13 L15 R16 R19 R45 Y53 P113 K187 C395 H447 K450 M451
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
Biological Process
GO:0006364 rRNA processing
GO:0006417 regulation of translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005730 nucleolus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ia0, PDBe:8ia0, PDBj:8ia0
PDBsum8ia0
PubMed37129998
UniProtG0S0I6

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