Structure of PDB 6hiy Chain CZ Binding Site BS01

Receptor Information

>6hiy Chain CZ (length=151) Species: 5702 (Trypanosoma brucei brucei)

IDHTFRDAVDAHFVGWRSKKIVEDIRRRHPVKLTIKEFQSPECAIGKLRE
MCQAMQHYAQEKVIYHHFTSIVANDREASITFAPALPMAKSDSWKHIKYP
GEKEWTNALRRMEDACRKSGRYGTYAKSNKLKLRSLGQTSYRVDKYGRKM
D

Ligand information

>6hiy Chain CA (length=478)

uaaauuauggucaauuguuaguauucauauuaauuuuuuuaaauguuuua
ucauuuuauaaagguuuauuuuugaaagauuuuuuguauaaaauuuuagg
aauaguuaauaauaauuuauaauuuugauuagauuguuuuguuaaugcua
uuagauggguguggaaaaauaaaaaaaauaauuaauauauaucaauaaua
aauuaaauuaaucuauuagucagaaauggaugccagccguugcgguaauu
ucuaugcuuuuaaauauuauacaauuaucauauuaaauuguuaaguguug
auuuaaccaauaaaaauauaaauaauuuuuauuuguuuuuaaacaccauu
agguauaugcaaauauaaaauuauaguaauuauaaauuauauuaaaaagg
uauuguugcccaccaauuuuuauaauaaaaauaacgugcaguaauuaaua
uauuuauaaaaauauauuuuuuuuuuuu

....................<<<.......<<<<..............<.
..>..........................................<<...
.<<...<<<.......>>>..>>.......>>........<<....>>..
..................................................
.................<<<.(...<<<<<.....<<..).>>.......
>>>>>>>>.......>>>>............<..................
.<.......>.....................>............<<<...
.>>>................<......>..>>>..<<.............
.>>....<<.<<<..<<<<<<.....>>>>>>...>>>..>>....<<<<
<<<<<....>>>>>>>>>..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6hiy Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
• Resolution: 3.27 Å
• Binding residue (original residue number in PDB): R215 A217 D219 H221 W225 K229 K341 L342 R343 S344 Q347 R351 K354
• Binding residue (residue number reindexed from 1): R6 A8 D10 H12 W16 K20 K132 L133 R134 S135 Q138 R142 K145

Gene Ontology

Cellular Component

• GO:0005739 mitochondrion

External links

• PDB: RCSB:6hiy, PDBe:6hiy, PDBj:6hiy
• PDBsum: 6hiy
• PubMed: 30213880
• UniProt: Q57WU2