Structure of PDB 4v6w Chain CX Binding Site BS01

Receptor Information
>4v6w Chain CX (length=120) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARKIRTNVHFRRPTTLKLPRSPKYPRKSVPTRNRMDAYNIIKYPLTTEAA
MKKIEDNNTLVFLTHLRANKNHVRAAVRKLYDIKVAKVNVLIRPDGQKKA
YVRLARDYDALDIANKIGII
Ligand information
>4v6w Chain A5 (length=3806) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuauauacaaccucaacucauaugggacuacccccugaauuuaagcauau
uaauuaggggaggaaaagaaacuaacaaggauuuucuuaguagcggcgag
cgaaaagaaaacaguucagcacuaagucacuuugucuauauggcaaaugu
gagaugcaguguauggagcgucaauauucuaguaugagaaauuaacgauu
uaaguccuucuuaaaugaggccauuuacccauagagggugccaggcccgu
auaacguuaaugauuacuagaugauguuuccaaagagucguguugcuuga
uagugcagcacuaagugggugguaaacuccaucuaaaacuaaauauaacc
augagaccgauaguaaacaaguaccgugagggaaaguugaaaagaacucu
gaauagagaguuaaacaguacgugaaacugcuuagagguuaagcccgaug
aaccugaauauccguuauggaaaauucaucauuaaaauuguaauauuuaa
auaauauuaugagaauagugugcauuuuuuccauauaaggacauuguaau
cuauuagcauauaccaaauuuaucauaaaauauaacuuauaguuuauucc
aauuaaauugcuugcauuuuaacacagaauaaauguuauuaauuugauaa
agugcugauagauuuauaugauuacagugcguuaauuuuucggaauuaua
uaauggcauaauuaucauugauuuuuguguuuauuauaugcacuuguaug
auuaacaaugcgaaagauucaggauaccuucgggacccgucuugaaacac
ggaccaaggagucuaacauaugugcaaguuauugggauauaaaccuaaua
gcguaauuaacuugacuaauaaugggauuaguuuuuuagcuauuuauagc
uaauuaacacaaucccggggcguucuauauaguuauguauaauguauauu
uauauuauuuaugccucuaacuggaacguaccuugagcauauaugcugug
acccgaaagauggugaacuauacuugaucagguugaagucaggggaaacc
cugauggaagaccgaaacaguucugacgugcaaaucgauugucagaauug
aguauaggggcgaaagaccaaucgaaccaucuaguagcugguuccuuccg
aaguuucccucaggauagcuggugcauuuuaauauuauauaaaauaaucu
uaucugguaaagcgaaugauuagaggccuuagggucgaaacgaucuuaac
cuauucucaaacuuuaaauggguaagaaccuuaacuuucuugauaugaag
aucaagguuaugauauaaaugucccagugggccacuuuugguaagcagaa
cuggcgcugugggaugaaccaaacguaauguuacgugcccaaauuaacaa
cucaugcagauaccaugaaaggcguugguugcuuaaaacagcaggacggu
gaucauggaagucgaaauccgcuaaggaguguguaacaacucaccugccg
aagcaacuagcccuuaaaauggauggcgcuuaaguuguauaccuauacau
uaccgcuaaaguagaugauuuauauuacuugugauauaaauuuugaaacu
uuagugaguaggaagguacaaugguaugcguagaaguguuuggcguaagc
cugcauggagcugccauugguacagaucuugguggauaguagcaaauaau
cgaaugagagccuuggaggacugaaguggagaaggguuucgugugaacag
ugguugaucacgaguuagucgguccuaaguucaaggcgaaagcgaaaauu
uucaaguaaaacauaauuuugaacgaaagggaauacgguuccaauuccgu
aaccuguugaguauccguuuguuauuaaauaugggccucgugcucauccu
ggcaacaggaacgaccauaaagaagccgucgagagauaucggaagaguuu
ucuuuucuguuuuauagccguacuaccauggaagucuuucgcagagagau
augguagaugggcuagaagagcaugacauauacuguugugucgauauuuu
cuccucggaccuugaaaauuuaugguggggacacgcaaacuucucaacag
gccguaccaauauccgcagcuggucuccaaggugaagagucucuagucga
uagaauaauguagguaagggaagucggcaaauuagauccguaacuucggg
auaaggauuggcucugaagauugagauagucggccuugauugggaaacaa
uauuguggaacuuucuugcuaaaauuuuuaauuauuaauuauaacgauua
ucaauuaacaaucaauucagaacuggcacggacuuggggaauccgacugu
cuaauuaaaacaaagcauugugauggcccuagcggguguugacacaaugu
gauuucugcccagugcucugaaugucaaagugaagaaauucaaguaagcg
cgggucaacggcgggaguaacuaugacucucuuaagguagccaaaugccu
cgucaucuaauuagugacgcgcaugaauggauuaacgagauuccuacugu
cccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggaaua
auuagcggggaaagaagacccuuuugagcuugacucuaaucuggcagugu
aaggagacauaagagguguagaauaagugggagauauuagaccucgguuu
gguaucgucaaugaaauaccacuacucuuauuguuuccuuacuuacuuga
uuaaauggaacguguaucauuuccuagccauuauacggauauauuuauua
uaucuuaugguauuggguuuugaugcaagcuucuugaucaaaguaucacg
aguuuguuauauaaucgcaaacaaauucuuuaauaaaacgaugcauuuau
guauuuuugauuugaaaauuugguauaacuccaauuacucagguaugauc
caauucaaggacauugccagguagggaguuugacuggggcgguacaucuc
ucaaauaauaacggaggugucccaaggccagcucagugcggacagaaacc
acacauagagcaaaagggcaaaugcugacuugaucucgguguucaguaca
cacagggacagcaaaagcucggccuaucgauccuuuugguuuaaagaguu
uuuaacaagaggugucagaaaaguuaccauagggauaacuggcuuguggc
ggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucu
uccuaucauugugaagcaaaauucaccaagcguuggauuguucacccaug
caagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuac
ccuacuaaugacaaaacguuguugcgacagcauuccugcguaguacgaga
ggaacccgcagguacggaccaauggcacaauacuuguucgagcgaacagu
gguaugacgcuacguccguuggauuaugccugaacgccucuaaggucgua
uccgugcuggacugcaaugauaaauaaggggcaauuugcauuguauggcu
ucuaaaccauuuaaaguuuauaauuuacuuuauaaacgacaauggaugug
augccaauguaauuuguaacauaguaaauugggaggaucuucgaucaccu
gaugccgcgcuaguuacauauaaaagcauuauuuaauacaaugacaaagc
cuagaaucaauuguaaacgacuuuuguaacaggcaagguguuguaagugg
uugagcagcugccauacugcgauccacugaagcuuauccuuugcuugaug
auucga
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Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v6w Structures of the human and Drosophila 80S ribosome.
Resolution6.0 Å
Binding residue
(original residue number in PDB)
A158 R159 K160 I161 R162 T163 N164 V165 H166 F167 R168 R169 T172 K174 L175 R177 P179 K180 T204 K210 N226 K227 N228 R231 N246 V247 L248 I249 K255 K256 Y258 R260
Binding residue
(residue number reindexed from 1)
A1 R2 K3 I4 R5 T6 N7 V8 H9 F10 R11 R12 T15 K17 L18 R20 P22 K23 T47 K53 N69 K70 N71 R74 N89 V90 L91 I92 K98 K99 Y101 R103
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4v6w, PDBe:4v6w, PDBj:4v6w
PDBsum4v6w
PubMed23636399
UniProtQ9W0A8

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