Structure of PDB 8i9t Chain CU Binding Site BS01

Receptor Information
>8i9t Chain CU (length=178) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INNKEGLLTALRRIQLDINPKTTPFSFHQSVVASKRTEDSIPQIEDDLQR
ELAFMNQALEAARLGRSLLRKEGVPFTRPTDYFAEMVRTDATMEKVKQKL
IEEATAKKAAAEARKQRDLKKFGKAVQVQKQLERAKQKREALDKINQLKR
KRAEGGALGATEADDPFDVAVDNELSRD
Ligand information
>8i9t Chain C1 (length=2132) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaaguga
acguaggugagagcuucggcgcaucaucgaccgauccugauguauucgga
uggauuugaguaggagcguuaagccuuggacccgaaagauggugaacaac
caucuaguagcugguuaccgccgaaguuucccucaggauagcagugucga
ccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcc
cuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggc
cauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguu
aaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacau
cuugacagcaggacgguggccauggaagucggaauccgcuaaggacugug
uaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaa
gcgucccacccauaccccgcccucaggguagaaacgaugcccugaggagu
aggcggccguggaggucagugacgaagccuagggcgugagcccgggucga
acggccucuagugcagaucuuggugguaguagcaaauuugauagaacaau
guagauaagggaagucggcgggaaucugcgagauucccacugucccuauc
uacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcg
gggaagacccuguugagcuugacucuaguuugacauugugaaaagacaua
ggagguguagaauaggugggagcuucggcgccagugaaauaccacuacuc
cuauuguuuuuuuacuuauucaaugugaagacauugucagguggggaguu
ccuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacaggga
uaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuuggaug
ucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguu
cacccacuaauagggaacguggaccgucgugagacagguuagucccuacu
gaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcuga
uucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcu
accaucugcuggauaauggcugaacgccucuaagucagaauccaugccag
aacgcgacgauaacccgcacguagacguauaagaauaggcuccggccucg
uauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauu
cgcguauugcaaagacacgcgcgggaucaaauccuuugcagacgacuuag
augugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucu
gcugaggguaagcccuccuucgccuagauuuc
........................<<<<<<.....<......>......>
>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>....>.............................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<<....<<.<<<<<<<<<<.<<.<<<
<<<....>>>>>>>>...>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>
>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<
<<<<<.<<<<..<<<...<<<<.....>>>>...>>>...<<....>>..
.....<<<<<..<<....>>...>>>>>.<<<<<<<<....<....>...
.>>>.>>>.>>....>>>>.>>>>>>>>>.<<.<..<<<<<<<.....>>
>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<<
....<<.<<<<<<<.....<<<........>>.>.....>>>>>....<<
..<<<<.<......>>>>>.>>.......>>>>..>>>>>>>>.>>..<<
<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<.
..<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<
.......<<<<<.<<<...<<.........>>...>>>.........<<.
.....>>...>>>>>...>>>>>>>>>>>>>..........))).>>...
>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>...
.>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...
>>>>>>>>>>..>.....>>>>>><<.....<.........<<<<.....
<<<<<<.<<<<<<<<....<<<<<<<<<>>.>>>>>>>>>>.>>>>>>>>
>>>..>>>>.>....>>....<<<<<........>>>>>....<<<<<.<
<<.....<<<<<<.<<<<<<.<<<<<..<<<<<<<..<<<<<<<<<<<<<
<<<<..........<<<<<......................>>>>>.>>>
>>>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>...>>>>>.
<<<<<<<..<<<<<<...>>>>>>>>>>>>>....>>>>>.>.>>>>>>.
............<<<<<<...<<.......>>...>>>>>>.....((..
......<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.....)
)..>>>.....>>>>>..>..<<<<<<<....>>>.>>>>....>>>.>>
>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>
.><<<<<...<<<<...<<<<<<<<<<<....>>>>>..>>>>>>..>>>
>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>.
...>>>>>>>...<<<<<.<<.......<<.......<<<....>>>...
.>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>
>>>..............>>.>>>>>...<<<<<<<.............>>
....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>
>>...>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8i9t Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R303 R306 K309 K313 V317 K319 R323 R328
Binding residue
(residue number reindexed from 1)		R114 R117 K120 K124 V128 K130 R134 R139
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0030687 preribosome, large subunit precursor
GO:0034399 nuclear periphery

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8i9t, PDBe:8i9t, PDBj:8i9t
PDBsum8i9t
PubMed37129998
UniProtG0SGC2

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