Structure of PDB 8ia0 Chain CT Binding Site BS01

Receptor Information
>8ia0 Chain CT (length=488) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQIRQAQEELAKIATQLNENPEEYPGHFKALARIGETPILAIQKLCIVTQ
MAVYKDVIPGYRIRPLGEKEVKRLRTYEQALVAGYHGYLKTLATYAASSI
PEDRKGEPISSIAFTCACELVNAVPHFNFRGDLLRILVKKLSTRKIDRDF
VKCREALEKLFQDDEEGNASQEAVSLLSKMMKAREYRVDESVLNLFLHLR
LLSKWEFRTKKQRKLLKAEKEAQKVMEQADATVSHEERERIQSEILKMVF
ATYFRILKARVPHLMGAVLEGLAKYAHLINQDFFGDLLEALKDLIRDTDR
DTSRESLLCTVTAFALLEGQDAHNARSDLHLDLSFFITNLYRSLLSLSLN
PDLELGNNKINLQTTTVLLLRCLTSVLLPPWNIRSVPPIRLAAFCKQLMT
LALQVPEKSSQAILGLLQDVVHTHGRKVAALWNTEERKGDGTYKPLSETV
EGSNPFTTTIWEGELLRKHYCPKVREGLKAMEKELRSI
Ligand information
>8ia0 Chain C1 (length=2928) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagc
uucggcgcaucaucgaccgauccugauguauucggauggauuugaguagg
agcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggug
aagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaa
ucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccga
aguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcg
aaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggu
cgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaug
cgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucaga
caccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaa
gucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuag
cccugaaaauggauggcgcucaagcgucccacccauaccccgcccucagg
guagaaacgaugcccugaggaguaggcggccguggaggucagugacgaag
ccuagggcgugagcccgggucgaacggccucuagugcagaucuugguggu
aguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguu
ccaugugaacagcgguuggacauggguuagucgauccuaagccauaggga
aguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccg
guuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaa
cgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaac
ggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccgg
aagagcccgacacuucugucggguccggugcgcucucgacgucccuugaa
aauccgcgggagggaauaauucucacgccaggucguacucauaaccgcag
cagguccccaaggugaacagccucugguugauagaacaauguagauaagg
gaagucggcauccguaacuucgggaaaagggcucuaaggguugggcacgu
ugggcuuugggcggacgcccugggagcagagggccucuagccgggcaacc
ggccggcggcccucagcacccgggguugaagcccuuagcccggcgugcgg
uuaacaaccaacuuagaacugguacggacagggaaucugacgucuauagc
auugcgauggccagaaagugguguugacgcaaugugucugcccagugcuc
ugaaugucaaagugaagaaauucaaccaagcgcggguaaaaugccucguc
aucuaauuagugacgcgcauggauaacgagauucccacugucccuaucua
cuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggg
gaagacccuguugagcuugacucuaguuugacauugugaaaagacauagg
agguguagaauaggugggagcuucggcgccagugaaauaccacuacuccu
auuguuuuuuuacuuauucaaugugaagacauugucagguggggaguucc
uuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggaua
acuggcuuguggcggccaagcguagcgacgucgcuucggcucuuccuauc
auaccgaagcagaauucgguaagcguuggauuguucacccacuaauaggg
aaagcuggggaccgucgugagacagguuagucccuacugaugaacucguc
gcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauug
guuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcugg
auaauggcugaacgccucuaagucagaauccaugccagaacgcgacgaua
cuacccgcacguuguagacguauaagaauaggcuccggccucguauccua
gcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguau
ugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugu
gcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcug
aggguaagcccuccuucgccuagauuuc
........................<<<<<<.....<<....>>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>..................................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<
<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.....<.<<<<<<<<......<<<<<<..>>>>>>.......>>>
>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<....<<<
<<<<<.<<<<..<<<...<<<<.....>>>>...>>>....<<<<<..<<
....>>...>>>>>.<<<<<<<<..............>>>.>>>.>>...
.>>>>.>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<.
..<<<<<<<....>>>>>>>....>>>>..<<<<<........>>>>>..
>>>>>>>>>..<<.<....>.>>.>>>>>>......>.>>...<<<<<..
..<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<..
......>>.>.....>>>>>....<<<.<<<<.<......>>>>>.>>>.
..>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....
<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<.
.........<<<.<<<<<<<<<<.......<<<<<.<<<...<<......
...>>...>>>.........<<......>>...>>>>>...>>>>>>>>>
>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<
<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<
<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.
....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...
<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<.
...>>>........<<<<<......>>>>>....>>>....>>...<<<<
<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......
<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><...<
<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.
...><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.......
..>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<....
..>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<
.......<..<<<<<<.<.<<.................<<<<<.<<<<<.
.<.<<<..<<<<....<<<<<<<<.<<.<<<<<<<.<<.<<<<<....>>
>>>.>>.>>>>>>>.>>.>>>>>>>>....>>>>..>>>>...>>>>>..
....>>>>>......>>...>.>>>>>>..<<<<<<<<<..<<<<...<<
<<<<<....<<<<.....>>>>......>>>>>>>...<<<<<.<<<<<.
<<<<<.<<........>>.>>>>>....>>>>>>>>>>..<<<<..<<<<
<<.......>>>>>>.>>>>>>>>..>>.>>>>>>>.>...>>.>>>>>>
>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<
<....<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<
<<..........<<<<<..<<....>>............>>>>>.>>>>>
>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>>..>>>>>.<<
<<<<<..<<<<<.....>>>>>>>>>>>>....>>>>>.>.>>>>>>...
..........<<<<<<...<<...>>...>>>>>><<<<<<.<<<<<..<
.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>
>.>>>>>>.<<<<<<<....>>>.>>>>....>>>.>>>>>....<<<<<
<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<
<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<<
<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>..
...<<<<<.<<.<<<......<<.......<<<....>>>....>>....
....<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>....
..........>>>>>.>>>>>...<<<<<<<.............>>....
<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>..
.>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ia0 Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		W360 E361 R363 T364 K365 R368 K369 K372 H499 N500 W579 N580 R582
Binding residue
(residue number reindexed from 1)		W205 E206 R208 T209 K210 R213 K214 K217 H323 N324 W381 N382 R384
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
Biological Process
GO:0006270 DNA replication initiation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ia0, PDBe:8ia0, PDBj:8ia0
PDBsum8ia0
PubMed37129998
UniProtG0S5L0

[Back to BioLiP]