Structure of PDB 8i9z Chain CT Binding Site BS01

Receptor Information
>8i9z Chain CT (length=488) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQIRQAQEELAKIATQLNENPEEYPGHFKALARIGETPILAIQKLCIVTQ
MAVYKDVIPGYRIRPLGEKEVKRLRTYEQALVAGYHGYLKTLATYAASSI
PEDRKGEPISSIAFTCACELVNAVPHFNFRGDLLRILVKKLSTRKIDRDF
VKCREALEKLFQDDEEGNASQEAVSLLSKMMKAREYRVDESVLNLFLHLR
LLSKWEFRTKKQRKLLKAEKEAQKVMEQADATVSHEERERIQSEILKMVF
ATYFRILKARVPHLMGAVLEGLAKYAHLINQDFFGDLLEALKDLIRDTDR
DTSRESLLCTVTAFALLEGQDAHNARSDLHLDLSFFITNLYRSLLSLSLN
PDLELGNNKINLQTTTVLLLRCLTSVLLPPWNIRSVPPIRLAAFCKQLMT
LALQVPEKSSQAILGLLQDVVHTHGRKVAALWNTEERKGDGTYKPLSETV
EGSNPFTTTIWEGELLRKHYCPKVREGLKAMEKELRSI
Ligand information
>8i9z Chain C1 (length=2787) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagc
uucggcgcaucaucgaccgauccugauguauucggauggauuugaguagg
agcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggug
aagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaa
ucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccga
aguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcg
aaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggc
auucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcg
augcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucauc
agacaccacaaaaggcguuaguacaucuugacagcaggacgguggccaug
gaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguac
uagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccuc
aggguagaaacgaugcccugaggaguaggcggccguggaggucagugacg
aagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggu
gguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaag
guuccaugugaacagcgguuggacauggguuagucgauccuaagccauag
ggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaag
ccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacu
gaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuu
aacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggc
cggaagagcccgacacuucugucggguccggugcgcucucgacgucccuu
gaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccg
cagcagguccccaaggugaacagccucugguugauagaacaauguagaua
agggaagucggcuccguaacuucgggaaaagggcucuaaggguugggcac
guugggcuuugggcggacgcccugggagcagagggccucuagccgggcaa
ccggccggcggcccucagcacccgggguugaagcccuuagcccggcgugc
gguuaacaaccaacuuagaacugguacggacacacugucccuaucuacua
ucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaa
agaagacccuguugagcuugacucuaguuugacauugugaaaagacauag
gagguguagaauaggugggagcuucggcgccagugaaauaccacuacucc
uauuguuuuuuuacuuauucaaugugaagacauugucagguggggaguuc
cuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggau
aacuggcuuguggcggccaagcguucauagcgacgucgcugaugucggcu
cuuccuaucauaccgaagcagaauucgguaagcguuggauuguucaccca
cuaauagggagugagcuggaccgucgugagacagguuagucccuacugau
gaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauuc
agauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuacc
aucugcuggauaauggcugaacgccucuaagucagaauccaugccagaac
gcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccu
cguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaa
uucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacga
cuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuac
gaucugcugaggguaagcccuccuucgccuagauuuc
........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>..................................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<
<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>
>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<....<<<
<<<<<.<<<<..<<<...<<<<.....>>>>...>>>....<<<<<..<<
....>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>...
.>>>>.>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<.
..<<<<<<<....>>>>>>>...>.>>>..<<<<<........>>>>>..
>>>>>>>>>..<<.<....>.>>.>>>>>>>.....>.>>...<<<<<..
..<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<..
......>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>
.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>.
...<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....
.<..........<<<.<<<<<<<<<<.....<.<<<<<.<<<...<<...
......>>...>>>.........<<......>>...>>>>>.>.>>>>>>
>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<
<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<....
..<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>>
<<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<
...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<
<<....>>>........<<<<<......>>>>>....>>>....>>...<
<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>....
...<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><.
..<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>
>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>....
.....>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<.
.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<
.<<.......<.<<<<<<.<.<<.................<<<<<.<<<<
<..<.<<<..<<<<....<<<<<<<<.<<.<<<<<<<.<<.<<<<<....
>>>>>.>>.>>>>>>>.>>.>>>>>>>>....>>>>..>>>>...>>>>>
......>>>>>......>>...>.>>>>>>....>...>>.>>>>>>>..
>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<..
......<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<
<<<..........<<<<<......................>>>>>.>>>>
>>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>>..>>>>>..
<<<<<<..<<<<<<...>>>>>>>>>>>>.....>>>>>.>.>>>>>>..
.((........<<<<<<...<<.......>>...>>>>>>((....<<<<
.<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<...))>.>>>
.....>>>>>)).>>>>.<<<<<<<....>>>.>>>>....>>>.>>>>>
....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><
<<<<...<<<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..
>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....
>>>>>>>.....<<<<<.<<.<<<......<<.......<<<....>>>.
...>>........<<<<.....<<<.<<<<<.......>>>>>.>>>...
.>>>>..............>>>>>.>>>>>...<<<<<<<..........
...>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>
..>>>>>...>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8i9z Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		W360 E361 R363 T364 K365 K366 R368 K369 K372 H499 N500 W579 N580 R582
Binding residue
(residue number reindexed from 1)		W205 E206 R208 T209 K210 K211 R213 K214 K217 H323 N324 W381 N382 R384
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
Biological Process
GO:0006270 DNA replication initiation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8i9z, PDBe:8i9z, PDBj:8i9z
PDBsum8i9z
PubMed37129998
UniProtG0S5L0

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