Structure of PDB 8i9y Chain CS Binding Site BS01

Receptor Information
>8i9y Chain CS (length=262) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAFFRLKEIDQTDALRRIAKGKMAMLTEDGDQLERELDAMYEHYKERKAS
QDAKYRAKRARQEVDDEEWEGLSARLEEDSSKPLIKDLSSKRARGFFSQD
VFQKIPGLWEERPNIDIITAEAMTLAHQLATGEKTKADLIDEGYNKYAFK
QKEGLPDWFLEDEAKHDKPIKPITKEAAQAIKEKLRALNARPIKKVAEAR
ARRKLRQAKKLEKLKQVKVVKATGANRGIKGRPKGVKGRYKMVDGRMKKE
MRALKRLAKKKR
Ligand information
>8i9y Chain C1 (length=2609) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagc
uucggcgcaucaucgaccgauccugauguauucggauggauuugaguagg
agcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggug
aagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaa
ucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccga
aguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcg
aaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggc
auucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcg
augcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucauc
agacaccacaaaaggcguuaguacaucuugacagcaggacgguggccaug
gaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguac
uagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccuc
aggguagaaacgaugcccugaggaguaggcggccguggaggucagugacg
aagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggu
gguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaag
guuccaugugaacagcgguuggacauggguuagucgauccuaagccauag
ggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaag
ccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacu
gaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuu
aacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggc
cggaagagcccgacacuucugucggguccggugcgcucucgacgucccuu
gaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccg
cagcagguccccaaggugaacagccucugguugauagaacaauguagaua
agggcugucccuaucuacuaucuagcgaaaccacagccaagggaacgggc
uuggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuu
gacauugugaaaagacauaggagguguagaauaggugggagcuucggcgc
cagugaaauaccacuacuccuauuguuuuuuuacuuauucaaugugaaga
cauugucagguggggaguuccuuuagucccucgaaauuugaggcuagagg
agaaaaguuaccacagggauaacuggcuuguggcggccaagcguagcgac
gucgcuuuuuggaugcggcucuuccuaucauaccgaagcagaauucggua
agcguuggauuguucacccacuaauagggaacgugagcuggaccgucgug
agacagguuagucccuacugaugaacucgucgcaaugguaauucagcuua
guacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgac
cgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucu
aagucagaauccaugccagaacgcgacgauacuacccgcacguuguagac
guauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccg
gccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcg
ggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagc
aguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgc
cuagauuuc
........................<<<<<<.....<<....>>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>..................................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<
<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>
>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<........>>>><<<<<<....<<<
<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>....<<<<<..<<
....>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>...
.>>>>.>>>>>>>>..<<.<...<<<<<<...<.<<<<<<<<<..<<<<.
..<<<<<<<....>>>>>>>...>.>>>..<<<<<........>>>>>..
>>>>>>>>>>.<<.<....>.>>.>>>>>>......>.>>...<<<<<..
..<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<..
......>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>
.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>.
...<<<......>>>...<<<<<<<...<<<((......<<<<<<.....
<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<...
......>>...>>>.........<<......>>...>>>>>...>>>>>>
>>>>>>>...........)).>>...>>>>>>.>>>...>>>>>>><<<<
<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<....
..<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>>
<<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<
...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<
<<....>>>........<<<<<......>>>>>....>>>....>>...<
<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>....
...<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><.
..<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>
>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>....
.....>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<.
.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<.
<<<......>>>>>>>>>..>>>>>>....>>....<<<<<........>
>>>>....<<<<<..<<<........<<<<<<.<<<<<<.<<<<<.<<<<
<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>..
..........>>>>>.>>>>>>>.>>>>>>>>>>...<<<<...>>>>..
...>>>>>>>>..>>>>>.<<<<<<<..<<<<<<...>>>>>>>>>>>>>
....>>>>>.>.>>>>>>.............<<<<<<...<<...>>...
>>>>>>.....((...<<<<<<<<<<..<.<<<<<<<......>>>>>>>
...>.<<<.....))..>>>.....>>>>>....>>>>>.<<<<<<<...
.>>>.>>>>....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<...
..............>>>>>.><<<<<...<<<<....<<<<<<<<<<)).
.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<..........
.>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<....
..<<.......<<<....>>>....>>........<<<<.....<<<.<<
<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>
>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<
<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>
...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8i9y Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y479 R482 K483 K683 A727 R728 R740 R743 E749 V791 K793 G796 R799 K813 V815 G817 R818 K821 E822 R824 R828 L829
Binding residue
(residue number reindexed from 1)		Y44 R47 K48 K146 A190 R191 R203 R206 E212 V219 K221 G224 R227 K241 V243 G245 R246 K249 E250 R252 R256 L257
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008649 rRNA methyltransferase activity
GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity
GO:0016435 rRNA (guanine) methyltransferase activity
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001510 RNA methylation
GO:0006364 rRNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0030687 preribosome, large subunit precursor

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8i9y, PDBe:8i9y, PDBj:8i9y
PDBsum8i9y
PubMed37129998
UniProtG0SGD8

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