Structure of PDB 4v7l Chain CR Binding Site BS01

Receptor Information
>4v7l Chain CR (length=70) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAKVKATLGEFDLRDYRNVEVLKRFLSETGKILPRRRTGLSAKEQRILAK
TIKRARILGLLPFTEKLVRK
Ligand information
>4v7l Chain CA (length=1495) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcggccguggucagcggcggacgggugaguaa
cgcgugggugaccuacccggaagagggggacaacccggggaaacucgggc
uaaucccccauguggacccgccccuugggguguguccaaagggcuuugcc
cgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcc
caccaaggcgacgacggguagccggucugagaggauggccggccacaggg
gcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuu
ccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcc
cuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggac
ugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgg
uaauacggagggcgcgagcguuacccggauucacugggcguaaagggcgu
guaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggg
gagcgugggauacgcucaggcuagacggugggagagggugguggaauucc
cggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaag
gcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagca
aaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuagg
ucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccugg
ggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcac
aagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuacca
ggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgag
gggagcccuagcacaggugcugcauggccgucgucagcucgugccgugag
guguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccag
cgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaagg
aggggacgacgucuggucagcauggcccuuacggccugggcgacacacgu
gcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaauc
gcaaaaaggugggcccaguucggauuggggucugcaacccgaccccauga
agccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguu
cccgggccuuguacacaccgcccgucacgccaugggagcgggcucuaccc
gaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacug
gggcgaagucguaacaagguagcuguaccggaaggugcggcugga
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<
.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<......
.<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.
....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>
>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>
>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<
<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........
<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<
<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..
........>>>>>......<<<<<(((...<<<<<.....<<.)))>>..
.....>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<
...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>..
..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<
<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....
>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<.
..<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<
<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<
<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<
.<<<<<<..<<<<<<<<<<......<<........>>..........<<<
<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>
>....>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>
>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...
<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>.......
.>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>
>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>
>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>..
.>.....>>>>>>....<<<<<<<..........>>>>>>>......>>.
..>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<
...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>
.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v7l The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K49 I50 A60 K61 R64 K68 K71 R72 R74 I75 F81
Binding residue
(residue number reindexed from 1)		K31 I32 A42 K43 R46 K50 K53 R54 R56 I57 F63
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0070181 small ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v7l, PDBe:4v7l, PDBj:4v7l
PDBsum4v7l
PubMed20154709
UniProtQ5SLQ0|RS18_THET8 Small ribosomal subunit protein bS18 (Gene Name=rpsR)

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