Structure of PDB 8cq7 Chain CP Binding Site BS01

Receptor Information
>8cq7 Chain CP (length=217) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGWTPVTKLGRLVKAGKITSVEQIYLHSLPVKEYQIIDLLLPDLKDDVMK
IRSVQKQTRAGQRTRMKAVVVIGDSNGHVGLGIKTAKEVASAIKAAIVIA
KLSIIPIRRGYWGSNLGQPHSLPCKVTGKCGSVAVRLIPAPRGKGIVASP
VVKRLMQLAGVEDVYTSSSGSTRTTENTLKAAFAAIGNTYSFLTPNLWAE
TPLAASPLEVYAEEAAA
Ligand information
>8cq7 Chain CM (length=1765) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguaccuuacuacuuggauaaccgu
gguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaaggga
uguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucau
aauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaau
uucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuca
acggguaacggggaauaaggguucgauuccggagagggagccugagaaac
ggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccga
cacggggagguagugacaauaaauaacgauacagggcccuuuugggucuu
guaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagg
gcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauau
uaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcugg
ccgguccauaugcguacuggacccagccgagccuuuccuucuggguagcc
auuuauggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaag
caggccuuugcucgaauauauuagcauggaauaauagaauaggacguuau
gguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacgg
ucggggguaucaguauucaguugucagaggugaaauucuuggauuuacug
aagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaag
aacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaacc
auaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaauc
ggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucg
caaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggag
ccugcggcuuaauuugacucaacacggggaaacucaccagguccagacac
aauaaggauugacagauugagagcucuuucuugauuuugugggugguggu
gcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaa
cgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguaua
gucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggca
auaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuaca
cugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuu
gugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaa
cgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagug
aggccuccggauugguuuaggaaauucuggaaccgagaagcuggucaaac
uuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaac
cugcggaaggaucau
...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<...............<<.....<..<
<.......>>..>......>>........<<<<<..<<....>>..>>>>
><...<<<<<<.........((((.<<<....>>>..............>
>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>
..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>....
..>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.........
.>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<.
..>>>>..>>>..>....>.>.....<<<<<<<<<<<<.....>>.>>>>
>>>.>>>......<<..<...........>..>>.........<<<<<((
......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>
>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<..
.......<..>.............>>>>>>>>>>.....<<<<.......
.............>>>>....<<<<<.<<.......<<...<.......>
..<<<....>>>....>>......>>.>>..>>>.........<<<..<<
<<<<<<<.....))))....>>>>>>>>>>>>.....>>....<<<<<<.
<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>
>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>
>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>.
.........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>
>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<.
...>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<
<.<<<<<<......<<........>>..........<<<<<.<....<<<
<<........<<.<<<........>>>.>>......>>>>>...<<.<<<
..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>
>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>..
..>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>..
...>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>...
..<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.
......>>>>>>>...........<<<<<<..........>>>>>>....
......>>>>>>....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<.
.<<<<..<...<<<<<<<.<.<...>.>.>>>>>>>...>..>>>>..>>
>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>
>>>>>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cq7 Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.2 Å
Binding residue
(original residue number in PDB)
R79 V81 Q82 K83 Q84 T85 R86 A87 Q89 R90 K94 K111 T154 K156 C157 G158 S159 R163 I165 K171 V174 A175 S176 Y192 T193 S195 S198 T199 R200 T201 N204 K207
Binding residue
(residue number reindexed from 1)
R52 V54 Q55 K56 Q57 T58 R59 A60 Q62 R63 K67 K84 T127 K129 C130 G131 S132 R136 I138 K144 V147 A148 S149 Y165 T166 S168 S171 T172 R173 T174 N177 K180
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