Structure of PDB 6rxx Chain CP Binding Site BS01

Receptor Information

>6rxx Chain CP (length=201) Species: 209285 (Thermochaetoides thermophila)

KWKIEPFLPGPFLEESSFMTLFPKYRERYLKDCWPLVTKALEKHGIAATL
DIVEGSMTVKTTRKTYDPAAILKARDLIKLLARSVPAPQALKILEDGMAC
DIIKIRSMVRNKERFVKRRQRLLGQNGTTLKALELLTQTYILVHGNTVSV
MGGYKGLKEVRRVVEDTMNNIHPIYLIKELMIKRELAKDPALAHEDWSRY
L

Ligand information

>6rxx Chain C1 (length=1221)

ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgggcucugugggugggggaauucaggag
gggaaaacgauaguuaccugguugauucugcuagucauaugcuugucuca
aauaagccaugcgucuaaguauaagcaauuauacagcgaaacugcgaaug
gcucauuaaaucaguuaucguuuauuugauaguaccuuacuacauggaua
accgugguaauucuagagcuaauacaugcugaaaaucccgacuucggaag
ggauguauuuauuagauuaaaaaccaaugcccuucggggcggugauucau
aauaacuucucgaaucgcacggccuuggccggcgaugguucauucaaauu
ucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaa
cggguaaggguuagggcucggagaaggagccugagaaacggcuacuacau
ccaaggaagggcaggcgcgcaaauuacccaaucccgacacggggagguag
ugacaauaaauacugauacagggcucuuucgggucuuguaauuggaauga
guacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugc
cagcagccgcgguaauuccagcuccaauagcguauauugcucguaguuga
accugggccuagcccgccgguccgccucaccgcgugcacuggcugggcug
ggccugauuaauagggacagucgggggcgucaguauucaauugucagagg
ugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaa
ggauguuuucauuaaucaggaacguaaacuauuagggaucggacggcguu
uauuuuugacccguucggcaccuuacgauaggaguauggucgcaaggcug
aaaaauugacggaagggcaccaccagggguggagccugcgcgcgcgcuac
acugacagagccagcgaguacucccuuggccgagaggcccggguaaucuu
guuaaacucugucgugcuggggauagagcauugcaauuauugcucuucaa
cgaggaaucccuaguaagcgcaagucaucagcuugcguugauuacguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauagaggaaguagguc
uccguaggugaaccugcggag

<<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>
>.>>>>............................................
.................................<<.<<<<<<...<.<<.
.....<<<.<<<<<....<<....<<.........>>...>>.>>.....
.<<<.......<<<..<<..<<....<<<...............<<..<.
.<..<<.......>>..>.....>>>........<<<<<..........>
>>>><...<<<<<<..............<<<<<..>>>>>.........>
>>>>>.....>...<<<<.<<<<....>>>>>>>>....>>>...>>>>.
.>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>.....
.>>>...<<<<....>>>>.>>>.<<.<<<<........>>>>.>>.<.<
<<..>>>.>.>>>>>>.........<<<...<<<<.....>>>.>>>>..
.>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....
<<..<...........>..>>.........<<<<<<.......<<<....
>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<
<...<<<<<<<<<<<<<<<<<.<<<......>>>...>>>>>>.>>>>>>
>>>>>..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<.
.....>>>......>.>>>>>>.>>>.......<<....>>...>>>>..
>>.>>>.>>>...>>>...>>.>...........<<..<<<<<<<<.<<<
.......>>>>>>>>>>>..>>............................
.......<<<<<<<<<<<<..<<.<<<<<<..<<<..........>>>..
...<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.
......>>>>>>>...........<<<<<<..........>>>>>>....
......>>>>>>....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>............>>>>>..<<<<.<<......>>.>>>>...<
<<<<<<<<....>>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rxx Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
• Resolution: 7.1 Å
• Binding residue (original residue number in PDB): N191 H193 H215 E216 W218
• Binding residue (residue number reindexed from 1): N170 H172 H194 E195 W197

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding

Biological Process

• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0032040 small-subunit processome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6rxx, PDBe:6rxx, PDBj:6rxx
• PDBsum: 6rxx
• PubMed: 31378463
• UniProt: G0S3V7