Structure of PDB 6rxu Chain CP Binding Site BS01

Receptor Information
>6rxu Chain CP (length=233) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWKIEPFLPGPFLEESSFMTLFPKYRERYLKDCWPLVTKALEKHGIAATL
DIVEGSMTVKTTRKTYDPAAILKARDLIKLLARSVPAPQALKILEDGMAC
DIIKIRSMVRNKERFVKRRQRLLGQNGTTLKALELLTQTYILVHGNTVSV
MGGYKGLKEVRRVVEDTMNNIHPIYLIKELMIKRELAKDPALAHEDWSRY
LKEAKQRAAEAERAEKARQKKEEKKREREKEFV
Ligand information
>6rxu Chain C1 (length=1575) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacgg
guaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgc
cgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagac
uccuaaggcgcaagggaauaccccgugcgccggggguugggcucuguggg
ugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccg
guuggggaagcccuagcggcugaaccucucggucgggccuccucuugggg
cgccuaggcggugucuucgggucgcgugcagccucccguccucgccugcc
gacagcgcucuggggaauucaggaggggaaagcagaugugccccgcggcg
agacuggcgcaccgccggacgagcugcuggggcacgcggguacgcuagcc
gcacgauaguuaccugguugauucugcuagucauaugcuugucucaaaua
agccaugcgucuaaguauaagcaauuauacagcgaaacugcgaauggcuc
auuaaaucaguuaucguuuauuugauaguaccuuacuacauggauaaccg
ugguaauucuagagcuaauacaugcugaaaaucccgacuucggaagggau
guauuuauuagauuaaaaaccaaugcccuucggggcggugauucauaaua
acuucucgaaucgcacggccuuggccggcgaugguucauucaaauuucug
cccuaucaacuuucgacggcuggguauuggccagccguggugacaacggg
uaaggguuagggcucggagaaggagccugagaaacggcuacuacauccaa
ggaagggcaggcgcgcaaauuacccaaucccgacacggggagguagugac
aauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguac
aauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaauagcguauauugcucguaguugaaccu
gggccuagcccgccgguccgccucaccgcgugcacuggcugggcugggcc
ugauuaauagggacagucgggggcgucaguauucaauugucagaggugaa
auucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggau
guuuucauuaaucaggaacguaaacuauuagggaucggacggcguuuauu
uuugacccguucggcaccuuacgauaggaguauggucgcaaggcugaaaa
auugacggaagggcaccaccagggguggagccugcgcgcgcgcuacacug
acagagccagcgaguacucccuuggccgagaggcccggguaaacucuguc
gugcugaggaaucccuaguaagcgcaagucaucagcuugcguugauuacg
ucccugcccuuuguacacaccgcccgucgcuacuaccgauagaggaagua
ggucuccguaggugaaccugcggag
<<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>
>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<
....>>>>>.>>>>..>>>>>.>>.>>>>>.......<<<<<..<<<<<<
<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>.....
......<<<<<<.<<<.....>>>.>>>>>>...................
......<<<...>>>.....................<<<<<..<<<<<<<
<..<<...<<<<.....>>>>...>>..>>>>>.>>>>>>>>.....<<<
<<<...<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>
....>>>>>>...........................<<<<.<<<<<<<.
.<.<<<<<.....>>>>>.>..>>>>>..>>>>>><<<<.<.....>.>>
>>...........................<<.<<<<<<...<.<<.....
.<<<.<<<<<....<<....<<.........>>...>>.>>......<<<
.......<<<..<<..<<....<<<...............<<..<..<..
<<.......>>..>.....>>>........<<<<<..........>>>>>
<...<<<<<<..............<<<<<..>>>>>.........>>>>>
>.....>...<<<<.<<<<....>>>>>>>>....>>>...>>>>..>>>
.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>
...<<<<....>>>>.>>>.<<.<<<<........>>>>.>>.<.<<<..
>>>.>.>>>>>>.........<<<...<<<<.....>>>.>>>>...>..
.>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....<<..
<...........>..>>.........<<<<<<.......<<<....>>>.
.................>>>>>>..>>>>>>>>.<.<<...<<<.<<...
<<<<<<<<<<<<<<<<<.<<<......>>>...>>>>>>.>>>>>>>>>>
>..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<.....
.>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>>.>
>>.>>>...>>>...>>.>...........<<..<<<<<<<<.<<<....
...>>>>>>>>>>>..>>................................
...<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>>>.>>>.....<
<<<<<<..............<<.<<<<....>>>>.>>.....>>>>>>>
..........>>>>>>....<<<<<<<<.......>>>>>>>>......>
>...>>>>>>>............>>>>>..<<<<.<<......>>.>>>>
...<<<<<<<<<....>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB6rxu Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K60 N132 R139 R142 Q146 N167 R183 N191 H193 K204 H215 E216 D217 W218 R283 K286 K290 K294 K295
Binding residue
(residue number reindexed from 1)		K39 N111 R118 R121 Q125 N146 R162 N170 H172 K183 H194 E195 D196 W197 R213 K216 K220 K224 K225
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6rxu, PDBe:6rxu, PDBj:6rxu
PDBsum6rxu
PubMed31378463
UniProtG0S3V7

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