Structure of PDB 6rxt Chain CP Binding Site BS01

Receptor Information

>6rxt Chain CP (length=201) Species: 209285 (Thermochaetoides thermophila)

KWKIEPFLPGPFLEESSFMTLFPKYRERYLKDCWPLVTKALEKHGIAATL
DIVEGSMTVKTTRKTYDPAAILKARDLIKLLARSVPAPQALKILEDGMAC
DIIKIRSMVRNKERFVKRRQRLLGQNGTTLKALELLTQTYILVHGNTVSV
MGGYKGLKEVRRVVEDTMNNIHPIYLIKELMIKRELAKDPALAHEDWSRY
L

Ligand information

>6rxt Chain C1 (length=1152)

ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacgg
guaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgc
cgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagac
uccuaaggcgcaagggaauaccccgugcgccggggguugggcucuguggg
ugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccg
guuggggaagcccuagcggcugaaccucucggucgggccuccucuugggg
cgccuaggcggugucuucgggucgcgugcagccucccguccucgccugcc
gacagcgcucuggggaauucaggaggggaaagcagaugugccccgcggcg
agacuggcgcaccgccggacgagcugcuggggcacgcggguacgcuagcc
gcacgauaguuaccugguugauucugcuagucauaugcuugucucaaaua
cccaaucccgacacggggagguagugacaauaaauacugauacagggcuc
uuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgagga
acaauuggagggcaagucuggugccagcagccgcgguaauuccagcucca
auagcguauauugcucguaguugaaccugauuaauagggacagucggggg
cgucaguauucaauugucagaggugaaauucuuggauuuauugaagacua
acaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacguaa
acuauuagggaucggacggcguuuauuuuugacccguucggcaccuuacg
auaggaguauggucgcaaggcugaaaaauugacggaagggcaccaccagg
gguggagccugcgcgcgcgcuacacugacagagccagcgaguacucccuu
ggccgagaggcccggguaaacucugucgugcugaggaaucccuaguaagc
gcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgc
ccgucgcuacuaccgauagaggaaguaggucuccguaggugaaccugcgg
ag

<<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>
>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<
....>>>>>.>>>>..>>>>>.>>.>>>>>.......<<<<<..<<<<<<
<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>.....
......<<<<<<.<<<.....>>>.>>>>>>...................
......<<<...>>>.....................<<<<<..<<<<<<<
<..<<...<<<<.....>>>>...>>..>>>>>.>>>>>>>>.....<<<
<<<...<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>
....>>>>>>...........................<<<<.<<<<<<<.
.<.<<<<<.....>>>>>.>..>>>>>..>>>>>><<<<.<.....>.>>
>>...........................<<.<<<<<<...<.<<..<.<
<<...<<<<.....>>>.>>>>..>>...>.>....<<<<<<<<<<<<<<
....>>>>>>>>>.>>>>>.....<<..<...........>..>>.....
....<<<<<<.......<<<....>>>..................>>>>>
>..>>>>>>>>.<.<<...<<<.<<.....>>....<<<<<<.<<...<<
<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.
......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>....
.......<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>.....
..............................<<<<<<<<<<<<..<<.<<<
<<<..<<<.<<<..>>>.>>>.....<<<<<<<..............<<.
<<<<....>>>>.>>.....>>>>>>>..........>>>>>>....<<<
<<<<<.......>>>>>>>>......>>...>>>>>>>............
>>>>>..<<<<.<<......>>.>>>>...<<<<<<<<<....>>>>>>>
>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rxt Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
• Resolution: 7.0 Å
• Binding residue (original residue number in PDB): K60 N132 R139 R142 Q146 N167 R183 N191 H193 K204 H215 E216 D217 W218
• Binding residue (residue number reindexed from 1): K39 N111 R118 R121 Q125 N146 R162 N170 H172 K183 H194 E195 D196 W197

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding

Biological Process

• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0032040 small-subunit processome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6rxt, PDBe:6rxt, PDBj:6rxt
• PDBsum: 6rxt
• PubMed: 31378463
• UniProt: G0S3V7