Structure of PDB 4v7l Chain CO Binding Site BS01

Receptor Information
>4v7l Chain CO (length=88) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHH
SHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIRG
Ligand information
>4v7l Chain CA (length=1495) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcggccguggucagcggcggacgggugaguaa
cgcgugggugaccuacccggaagagggggacaacccggggaaacucgggc
uaaucccccauguggacccgccccuugggguguguccaaagggcuuugcc
cgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcc
caccaaggcgacgacggguagccggucugagaggauggccggccacaggg
gcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuu
ccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcc
cuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggac
ugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgg
uaauacggagggcgcgagcguuacccggauucacugggcguaaagggcgu
guaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggg
gagcgugggauacgcucaggcuagacggugggagagggugguggaauucc
cggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaag
gcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagca
aaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuagg
ucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccugg
ggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcac
aagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuacca
ggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgag
gggagcccuagcacaggugcugcauggccgucgucagcucgugccgugag
guguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccag
cgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaagg
aggggacgacgucuggucagcauggcccuuacggccugggcgacacacgu
gcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaauc
gcaaaaaggugggcccaguucggauuggggucugcaacccgaccccauga
agccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguu
cccgggccuuguacacaccgcccgucacgccaugggagcgggcucuaccc
gaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacug
gggcgaagucguaacaagguagcuguaccggaaggugcggcugga
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<
.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<......
.<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.
....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>
>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>
>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<
<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........
<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<
<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..
........>>>>>......<<<<<(((...<<<<<.....<<.)))>>..
.....>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<
...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>..
..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<
<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....
>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<.
..<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<
<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<
<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<
.<<<<<<..<<<<<<<<<<......<<........>>..........<<<
<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>
>....>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>
>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...
<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>.......
.>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>
>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>
>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>..
.>.....>>>>>>....<<<<<<<..........>>>>>>>......>>.
..>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<
...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>
.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v7l The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		P2 K8 T22 G23 S24 T25 Q28 L31 R35 H42 H46 D49 H50 H51 S52 R54 M58 M59 Q62 R65 Y69 R72
Binding residue
(residue number reindexed from 1)		P1 K7 T21 G22 S23 T24 Q27 L30 R34 H41 H45 D48 H49 H50 S51 R53 M57 M58 Q61 R64 Y68 R71
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v7l, PDBe:4v7l, PDBj:4v7l
PDBsum4v7l
PubMed20154709
UniProtQ5SJ76|RS15_THET8 Small ribosomal subunit protein uS15 (Gene Name=rpsO)

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