Structure of PDB 6zqb Chain CN Binding Site BS01

Receptor Information

>6zqb Chain CN (length=232) Species: 559292 (Saccharomyces cerevisiae S288C)

IEDISAMKNGFIVVPFKLPDHKALPASLHFMFAKRHQSSNSNESDCLFLV
NLPLLSNIEHMKKFVGQLCGKYDTVSHVEELLYNDEFGLHEVDLSALTSP
RNTALLKFVDAASINNCWNALKKYSNLHAKHPNELFEWTYTTPSFTTFVN
FYKPLDIDYLKEDIHTHMAIFEQREAQAQEDVQSSIVDEDGFTLVVGKNT
KSLNSIRKKILNKKAKKDFYRFQVRERKKQEI

Ligand information

>6zqb Chain D3 (length=1198)

aagauaguuaucugguugauccugccagucauaugcuugucucagccaug
cagucuaaguauaagcaauuuauacagugaaacugcgaaugcucauuaaa
ucaguuaucguuuauuugauagucaugguauaacugugguaauucuagag
cuaaaaucucgacccuuuggaagagauguauuuauuagaucaaugucuuc
ggacucuuugaugaauaacuuuucgaaucgcauggccuugugcuggcgau
gguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggcc
uaccaugguuucaacggguaacggggaauaaggguucgauuccggagagg
gagccugagaaacggcuaccacauccaaggaagggcaggcuuacccaauc
cuaauucagggagguagugacaauaaauaacgauacagggcccauucggg
ucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauug
gagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcgu
auauugcucguaguugaacuuugggcccgguuggccggucggauuuccaa
cggggccuuuauuaauagggacggucgggggcaucaguauucaauuguca
gaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuug
ccaaggacguuuucauuaaucaagaacgaaaaacuaugccgacuagggau
cgggugguguuuuuuuaaugacccacucggcaccuuacgaggaguauggu
cgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggagugg
agccugcggaaacucaccagguccagacacaauauuugugggugguggug
caugugaugcccuuguucuggcgcgcgcuacacugacggagccagcgagu
cuaaccuuggccgagaggucuugguaaaaacuccgucggggaacgaggaa
uuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuu
uguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccuc
aggaucugcuuagagaagggggcaacuccucucagagcggagauuuggac
aaacuuggucauuuagaggaacuaaguuuccguaggugaaccugcgga

..............................<<<<<<...<....<<<.<<
<.<<....<.....<............>....>.>>.....<<<......
.<<<..<<..<<....<<<..............<<.<<<.....>>>.>>
.....<<<<<..<......>..>>>>>....<<<<...<<<<<.<<<...
.>>>...>>>>>..>>>>.........<<<<..<<<.....>>>.>>>>.
...>>>...>>>>..>>>.<<<....<<.....<<<<<<<<.......>>
>>>>>>.>>......>>>.....<<...............>>..>>>.<<
.<<<..........>>>.>>.<.<<....>>.>.>>>>>>..<<<....<
<<.....>>>..>>>.........>.....<<<<<<<.<<<<<....>>>
>>.>>>.>>>>......<<..<...........>..>>.........<<<
<<<.......<<<....>>>..................>>>>>>..>>>>
>>...<.<<...<<<.<<.....<<<<<.<<<<<............>>>>
>.>>>>>....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...
<<<......>>>......>.>>>>>>..>>.......<<....>>...>>
>>...>>>>>.>>>...>>>...>>.>............<<...<<<..<
<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>...........
.......<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..
<<<.<<<<........<<<<..<....<<<<<...>>>>>......<<<<
.......>>>>...>..>>>>>>>>.>>>.....<<<<<<<.........
...<<<..<<<<....>>>>..>>>.....>>>>>>>............>
>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>
............>>>>>..<<<<.<<....<<<<<<<<.<<.....<<..
....<<<<<<<.<<<<.<.<......>.>>>>>.>>>>>>>.....>>..
...>>.>>>>>>>>...>>.>>>>....<<<<<<<<....>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zqb 90 S pre-ribosome transformation into the primordial 40 S subunit.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): K218 N219 K221 S225 K228 K229
• Binding residue (residue number reindexed from 1): K198 N199 K201 S205 K208 K209

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0006364 rRNA processing
• GO:0030490 maturation of SSU-rRNA
• GO:0042254 ribosome biogenesis
• GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
• GO:0060962 regulation of ribosomal protein gene transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0032040 small-subunit processome
• GO:0032545 CURI complex
• GO:0034456 UTP-C complex

External links

• PDB: RCSB:6zqb, PDBe:6zqb, PDBj:6zqb
• PDBsum: 6zqb
• PubMed: 32943521
• UniProt: P25368|RRP7_YEAST Ribosomal RNA-processing protein 7 (Gene Name=RRP7)