Structure of PDB 6zqg Chain CM Binding Site BS01

Receptor Information
>6zqg Chain CM (length=360) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KYTTFQGSQNFRLRIVLATLSGKPIKIEKIRSGDLNPGLKDYEVSFLRLI
ESVTNGSVIEISYTGTTVIYRPGIIVGGASTHICPSSKPVGYFVEPMLYL
APFSKKKFSILFKGITASHNDAGIEAIKWGLMPVMEKFGVRECALHTLKR
GSPPLGGGEVHLVVDSLIAQPITMHEIDRPIISSITGVAYSTRVSPSLVN
RMIDGAKKVLKNLQCEVNITADVWRGENSGKSPGWGITLVAQSKQKGWSY
FAEDIGDAGSIPEELGEKVACQLLEEISKSAAVGRNQLPLAIVYMVIGKE
DIGRLRINKEQIDERFIILLRDIKKIFNTEVFLKPVDEADNEDMIATIKG
IGFTNTSKKI
Ligand information
>6zqg Chain D3 (length=1387) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuauguugcaguuaaaaagcucguaguugaacuuugggcccgguuggcc
ggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuugu
ggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaa
gcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguu
ugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacg
gucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauu
gaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaa
gaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaac
cauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacu
cggcaccuuacgagaaaucaaagucuuuggguucuggggggaguaugguc
gcaaggcuaaagacggaagggcaccaccaggaguggagccugcggcuuac
acgcgcgcuacacugacggagccagcgagucuaaccuuggccgagagguc
uugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauua
uugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguu
gauuacgucccugcccuuuguacacaccgcccgucgcuaguaccggaacu
aauuccguaggugaaccugcggaaggaucauuaaaga
<..<<<<<.......>>>>>.><..<<<<<<...<.<..........<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..................<.....<<
.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>
>>><.<.<<<<<<......((((((..<<<....>>>.............
.>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>.......>.>.....<<<<<.................
...>>.>>>......<<..<...........>..>>.........<<<<<
<.......<<<....>>>..................>>>>>>..>>>>>>
.>.......<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<..
..........>>>>>.>>>>>>....<<<<<<.........<<<......
.>>>.........>>>>>>...<<<<<.<<.......<<...<.......
>..<<<.....>>>....>>......>>.>>..>>>.........<<<..
..<<<<<.......))))))..>>>>>...>>>.....>>....<<<<<<
.<<...<<<<..<<..<<<<<<.<...<<<..(...>>>......>.>>>
>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...
>>.>....<<<<<<<...<...<<<<..)......>>>>...>>>>>>>>
..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>
>>>..>>>...<<..]]>>...>>.....>>>.>>>..............
...........<<<<<<<<<<<<..<<.<<<<<...<<<.<<<<......
.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>
..>>....>>.......>>>>>>>...........<<<<<<.........
.>>>>>>...........>>>>>....<<<<<<<.........>>>>>>>
......>>...>>>>>>>............>>>>>..<<<<.<<>>.>>>
>.<<<<<<<<<....>>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zqg 90 S pre-ribosome transformation into the primordial 40 S subunit.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K213 L216 C221 N224 I225
Binding residue
(residue number reindexed from 1)		K207 L210 C215 N218 I219
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003963 RNA-3'-phosphate cyclase activity
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:2000232 regulation of rRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0032040 small-subunit processome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zqg, PDBe:6zqg, PDBj:6zqg
PDBsum6zqg
PubMed32943521
UniProtQ08096|RCL1_YEAST RNA 3'-terminal phosphate cyclase-like protein (Gene Name=RCL1)

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