Structure of PDB 4v7m Chain CM Binding Site BS01

Receptor Information
>4v7m Chain CM (length=118) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEA
EVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQ
RTRTNARTRKGPRKTVAG
Ligand information
>4v7m Chain CA (length=1493) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgcguggucagcggcggacgggugaguaacg
cgugggugaccuacccggaagagggggacaacccggggaaacucgggcua
aucccccauguggacccgccccuugggguguguccaaagggcuuugcccg
cuuccggaugggcccgcgucccaucagcuaguuggugggguaauggccca
ccaaggcgacgacggguagccggucugagaggauggccggccacaggggc
acugagacacgggccccacuccuacgggaggcagcaguuaggaaucuucc
gcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccu
ucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacug
acgguaccgggguaauagcgccggccaacuccgugccagcagccgcggua
auacggagggcgcgagcguuacccggauucacugggcguaaagggcgugu
aggcggccuggggcgucccaugugaaagaccacggcucaaccguggggga
gcgugggauacgcucaggcuagacggugggagagggugguggaauucccg
gaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggc
agccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaa
ccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuagguc
ucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccugggg
aguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaa
gcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccagg
ccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggg
gagcccuagcacaggugcugcauggccgucgucagcucgugccgugaggu
guuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcg
guucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggag
gggacgacgucuggucagcauggcccuuacggccugggcgacacacgugc
uacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgc
aaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaag
ccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucc
cgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccga
agucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggg
gcgaagucguaacaagguagcuguaccggaaggugcggcugga
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<
.<<<..<<<..<<..<<<<<..>>>>>..>>>>>......<<.......<
<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>...
..>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.
>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>
>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<
.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<
<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<.
...>>>>.....>>>>....<<<<<........<<<<.....>>>>....
......>>>>>......<<<<<(((...<<<<<.....<<.)))>>....
...>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<..
.<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....
>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<
<.<..<<<......>>>.....>.>>>>>>>...........<<....>>
.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...
<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<
<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.
.....<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<
<<<<<..<<<<<<<<<<......<<........>>..........<<<<<
<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>>.
...>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>
..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<
<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>
>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>
>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>
.....>>>>>>>...........<<<<<<<........>>>>>>>.....
.....>>>>>>....<<<<<<<..........>>>>>>>......>>...
>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..
.<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>
>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...
Receptor-Ligand Complex Structure
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PDB4v7m The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.
Resolution3.45 Å
Binding residue
(original residue number in PDB)
K13 R14 V17 Y21 I22 Y23 G24 I25 G26 A28 R29 R44 V74 N77 I78 Y87 R88 R91 H92 L96 P97 V98 R99 Q101 R102 T103 R104 T105 N106 A107 R108 T109 R110 K111 R114 K115 T116
Binding residue
(residue number reindexed from 1)
K12 R13 V16 Y20 I21 Y22 G23 I24 G25 A27 R28 R43 V73 N76 I77 Y86 R87 R90 H91 L95 P96 V97 R98 Q100 R101 T102 R103 T104 N105 A106 R107 T108 R109 K110 R113 K114 T115
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4v7m, PDBe:4v7m, PDBj:4v7m
PDBsum4v7m
PubMed20154709
UniProtP80377|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)

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