Structure of PDB 6zqg Chain CL Binding Site BS01

Receptor Information
>6zqg Chain CL (length=710) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQSNKQHRKAKEKNTAKKKLHTQGHNAKAFAVAAPGKMARTMQRSSDVNE
RKLHVPMVDRTPEDDPPPFIVAVVGPPGTGKTTLIRSLVRRMTKSTLNDI
QGPITVVSGKHRRLTFLECPADDLNAMIDIAKIADLVLLLIDGNFGFEME
TMEFLNIAQHHGMPRVLGVATHLDLFKSQSTLRASKKRLKHRFWTEVYQG
AKLFYLSGVINGRYPDREILNLSRFISVMKFRPLKWRNEHPYMLADRFTD
LTHPELIETQGLQIDRKVAIYGYLHGTPLPSAPGTRVHIAGVGDFSVAQI
EKLPDPCPTPFYQQKLDDFERDKDKLIYAPMSDVNIGKLIYMDNISPEEC
IRRWRGVDLEKFVPYFDTFEKLAKKWKSVDAIKERFLREMNAAKKEKLRA
QFEIEEGENFKYDTWYELQKAKISKQLEINNIEYQEMTPEQRQRIEGFKA
GSYVRIVFEKVPMEFVKNFNPKFPIVMGGLLPTEIKFGIVKARLRRHRWH
KKILKTNDPLVLSLGWRRFQTLPIYTTTDSRTRTRMLKYTPEHTYCNAAF
YGPLCSPNTPFCGVQIVANSDTGNGFRIAATGIVEEIDVNIEIVKKLKLV
GFPYKIFKNTAFIKDMFSSAMEVARFEGAQIKTVSGIRGEIKRALSKPEG
HYRAAFEDKILMSDIVILRSWYPVRVKKFYNPVTSLLLKEKTEWKGLRLT
GQIRAAMNLE
Ligand information
>6zqg Chain D3 (length=1387) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuauguugcaguuaaaaagcucguaguugaacuuugggcccgguuggcc
ggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuugu
ggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaa
gcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguu
ugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacg
gucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauu
gaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaa
gaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaac
cauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacu
cggcaccuuacgagaaaucaaagucuuuggguucuggggggaguaugguc
gcaaggcuaaagacggaagggcaccaccaggaguggagccugcggcuuac
acgcgcgcuacacugacggagccagcgagucuaaccuuggccgagagguc
uugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauua
uugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguu
gauuacgucccugcccuuuguacacaccgcccgucgcuaguaccggaacu
aauuccguaggugaaccugcggaaggaucauuaaaga
<..<<<<<.......>>>>>.><..<<<<<<...<.<..........<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..................<.....<<
.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>
>>><.<.<<<<<<......((((((..<<<....>>>.............
.>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>.......>.>.....<<<<<.................
...>>.>>>......<<..<...........>..>>.........<<<<<
<.......<<<....>>>..................>>>>>>..>>>>>>
.>.......<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<..
..........>>>>>.>>>>>>....<<<<<<.........<<<......
.>>>.........>>>>>>...<<<<<.<<.......<<...<.......
>..<<<.....>>>....>>......>>.>>..>>>.........<<<..
..<<<<<.......))))))..>>>>>...>>>.....>>....<<<<<<
.<<...<<<<..<<..<<<<<<.<...<<<..(...>>>......>.>>>
>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...
>>.>....<<<<<<<...<...<<<<..)......>>>>...>>>>>>>>
..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>
>>>..>>>...<<..]]>>...>>.....>>>.>>>..............
...........<<<<<<<<<<<<..<<.<<<<<...<<<.<<<<......
.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>
..>>....>>.......>>>>>>>...........<<<<<<.........
.>>>>>>...........>>>>>....<<<<<<<.........>>>>>>>
......>>...>>>>>>>............>>>>>..<<<<.<<>>.>>>
>.<<<<<<<<<....>>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zqg 90 S pre-ribosome transformation into the primordial 40 S subunit.
Resolution3.5 Å
Binding residue
(original residue number in PDB)
Q3 N5 K6 H8 R9 K10 H22 N27 A30 F31 A34 A35 G37 K38 R41 M43 Q44 R45 H55 V56 M58 R166 K191 Y199 R225 K231 R233 P234 E733 D748 K755 K837 I838 K840 R870 K873 Y874 T879 K931 K933 F942 K943 V969 R973 K977 R978 K982 P983 E984 R988 E992 D993
Binding residue
(residue number reindexed from 1)
Q2 N4 K5 H7 R8 K9 H21 N26 A29 F30 A33 A34 G36 K37 R40 M42 Q43 R44 H54 V55 M57 R165 K190 Y198 R224 K230 R232 P233 E405 D413 K420 K502 I503 K505 R535 K538 Y539 T544 K596 K598 F607 K608 V634 R638 K642 R643 K647 P648 E649 R653 E657 D658
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016887 ATP hydrolysis activity
GO:0034511 U3 snoRNA binding
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:2000232 regulation of rRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0030686 90S preribosome
GO:0032040 small-subunit processome

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6zqg, PDBe:6zqg, PDBj:6zqg
PDBsum6zqg
PubMed32943521
UniProtQ08965|BMS1_YEAST Ribosome biogenesis protein BMS1 (Gene Name=BMS1)

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