Structure of PDB 1vy6 Chain CL Binding Site BS01

Receptor Information
>1vy6 Chain CL (length=122) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRK
VAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGV
YDAAGVKDRKKSRSKYGTKKPK
Ligand information
>1vy6 Chain CA (length=1503) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga
caugcaagucgugcgggccgcgggguacuccguggucagcggcggacggg
ugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaa
cucgggcuaaucccccauguggacccgccccuugggguguguccaaaggg
cuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggggu
aauggcccaccaaggcgacgacggguagccggucugagaggauggccggc
cacaggggcacugagacacgggccccacuccuacgggaggcagcaguuag
gaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagga
agaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacg
aggggacugacgguaccgggguaauagcgccggccaacuccgugccagca
gccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaa
agggcguguaggcggccuggggcgucccaugugaaagaccacggcucaac
cgugggggagcgugggauacgcucaggcuagacggugggagaggguggug
gaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgau
ggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgug
gggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcg
cgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgc
cgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggggg
cccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaac
cuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugcc
ccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgug
ccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuag
uugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcggg
aggaaggaggggacgacgucuggucagcauggcccuuacggccugggcga
cacacgugcuacaaugcccacuacaaagcgaugccacccggcaacgggga
gcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgac
cccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcgguga
auacguucccgggccuuguacacaccgcccgucacgccaugggagcgggc
ucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggccc
gugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug
gau
.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<
<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<
<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<.....
.>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<
<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<..
.....>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>
.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>.
.......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<..
....<<<<....>>>>.....>>>>....<<<<<........<<<<....
.>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.
)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>
>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.
...<<<<<<<.<..<<<......>>>.....>.>>>>>>>..........
.<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<
<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<
<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>
.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<
<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>......
....<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<
<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<
<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<
..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>
........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>
..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..
>>....>>>.....>>>>>>>......<....<<<<<<<........>>>
>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>..
....>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<
<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>
>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.
...
Receptor-Ligand Complex Structure
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PDB1vy6 A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		P5 T6 N8 Q9 R12 R15 E16 L27 A30 P31 F32 R33 R34 K46 N49 S50 R53 K54 Y69 G72 E73 R86 G87 V90 K91 D92 R97 V104 R113 K114 K115 S116 R117 S118 K119 Y120 K123
Binding residue
(residue number reindexed from 1)		P1 T2 N4 Q5 R8 R11 E12 L23 A26 P27 F28 R29 R30 K42 N45 S46 R49 K50 Y65 G68 E69 R82 G83 V86 K87 D88 R93 V100 R109 K110 K111 S112 R113 S114 K115 Y116 K119
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1vy6, PDBe:1vy6, PDBj:1vy6
PDBsum1vy6
PubMed25132179
UniProtQ5SHN3|RS12_THET8 Small ribosomal subunit protein uS12 (Gene Name=rpsL)

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