Structure of PDB 6rxx Chain CK Binding Site BS01

Receptor Information
>6rxx Chain CK (length=297) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLRKQARQRRDYLYRRALLLRDAEIAEKRAKLRAALASGKPLDPKIANDK
ELRKDFDYDVSRDIAKEQGEIDIDDEYSELSGIVDPRVLVTTSRDPSSRL
MAFSKEIRLMFPTAIRLNRGNLILPDLVMSAQRERLSDIILLHEHRGTPT
AITISHFPHGPTLMASLHNVVLRADIPKSIKGTVSESYPHLIFEGFRTPL
GQRVVKILKHLFPPRDPTNNAKSGNRVITFVNQDDCIEVRHHVYVRTNYN
SVELSEVGPRFTMRPFSITMGTLENKDADVEWHLSQYTRTGRKKNYF
Ligand information
>6rxx Chain C1 (length=1221) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgggcucugugggugggggaauucaggag
gggaaaacgauaguuaccugguugauucugcuagucauaugcuugucuca
aauaagccaugcgucuaaguauaagcaauuauacagcgaaacugcgaaug
gcucauuaaaucaguuaucguuuauuugauaguaccuuacuacauggaua
accgugguaauucuagagcuaauacaugcugaaaaucccgacuucggaag
ggauguauuuauuagauuaaaaaccaaugcccuucggggcggugauucau
aauaacuucucgaaucgcacggccuuggccggcgaugguucauucaaauu
ucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaa
cggguaaggguuagggcucggagaaggagccugagaaacggcuacuacau
ccaaggaagggcaggcgcgcaaauuacccaaucccgacacggggagguag
ugacaauaaauacugauacagggcucuuucgggucuuguaauuggaauga
guacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugc
cagcagccgcgguaauuccagcuccaauagcguauauugcucguaguuga
accugggccuagcccgccgguccgccucaccgcgugcacuggcugggcug
ggccugauuaauagggacagucgggggcgucaguauucaauugucagagg
ugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaa
ggauguuuucauuaaucaggaacguaaacuauuagggaucggacggcguu
uauuuuugacccguucggcaccuuacgauaggaguauggucgcaaggcug
aaaaauugacggaagggcaccaccagggguggagccugcgcgcgcgcuac
acugacagagccagcgaguacucccuuggccgagaggcccggguaaucuu
guuaaacucugucgugcuggggauagagcauugcaauuauugcucuucaa
cgaggaaucccuaguaagcgcaagucaucagcuugcguugauuacguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauagaggaaguagguc
uccguaggugaaccugcggag
<<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>
>.>>>>............................................
.................................<<.<<<<<<...<.<<.
.....<<<.<<<<<....<<....<<.........>>...>>.>>.....
.<<<.......<<<..<<..<<....<<<...............<<..<.
.<..<<.......>>..>.....>>>........<<<<<..........>
>>>><...<<<<<<..............<<<<<..>>>>>.........>
>>>>>.....>...<<<<.<<<<....>>>>>>>>....>>>...>>>>.
.>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>.....
.>>>...<<<<....>>>>.>>>.<<.<<<<........>>>>.>>.<.<
<<..>>>.>.>>>>>>.........<<<...<<<<.....>>>.>>>>..
.>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....
<<..<...........>..>>.........<<<<<<.......<<<....
>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<
<...<<<<<<<<<<<<<<<<<.<<<......>>>...>>>>>>.>>>>>>
>>>>>..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<.
.....>>>......>.>>>>>>.>>>.......<<....>>...>>>>..
>>.>>>.>>>...>>>...>>.>...........<<..<<<<<<<<.<<<
.......>>>>>>>>>>>..>>............................
.......<<<<<<<<<<<<..<<.<<<<<<..<<<..........>>>..
...<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.
......>>>>>>>...........<<<<<<..........>>>>>>....
......>>>>>>....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>............>>>>>..<<<<.<<......>>.>>>>...<
<<<<<<<<....>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB6rxx Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
Resolution7.1 Å
Binding residue
(original residue number in PDB)		S93 R94 G120 N121 I123 L124 E144 H145 S166 T183 V184 S185 E186 Y249 E281 W282 H283 L284 S285 Q286 Y287 T288 R289 T290
Binding residue
(residue number reindexed from 1)		S93 R94 G120 N121 I123 L124 E144 H145 S166 T183 V184 S185 E186 Y249 E281 W282 H283 L284 S285 Q286 Y287 T288 R289 T290
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0019843 rRNA binding
GO:0030515 snoRNA binding
GO:0042134 rRNA primary transcript binding
Biological Process
GO:0006364 rRNA processing
Cellular Component
GO:0005730 nucleolus
GO:0032040 small-subunit processome
GO:0034457 Mpp10 complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6rxx, PDBe:6rxx, PDBj:6rxx
PDBsum6rxx
PubMed31378463
UniProtG0SE90

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