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Receptor Information

>6rxu Chain CI (length=822) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ARQAARSHDIKEKRLHVPLVDRLPDEPPPRLVVIVGPPGVGKTTLLKSLV
RRYTKETMSDPVGPITVVTSKKQRLTFIECPNELEAMIDMAKVADIVLLM
IDGNYGFEMETMEFLNILANTGMPGNVFGILTHLDLFKKPSALKDAKKRL
KHRLWTELYQGAHLFYLSGVLNGRYPDREIHNLSRFLSVMKNPRPLVWRN
THPYTIIDNYRDITHPTKIEEDPLCDRTIELSGYLRGTNFAAQGQRVHIA
GVGDFTISKIEELPDPCPTPAMEKAPRRRLDEKDKKLWAPMADRSGMKIS
GDHIVITREKGFTFDKDANVERGEGEQLIVDLQGEKKLLGQTDKGVKLFA
GGEQLTQKPWRAIDLARLMYDTTLTPAQALRRWRGDYEELKTKWSNPENI
DALRRTRFQWYEMQKAMLQKQLDINKAEYAELDEHQRRQVEGYRAGKYAR
LVIEGVPAEFCKNFQPRMPILVGGLSATEDRFGFVQVRIKRHRWHKKILK
TGDPLIFSLGWRRFQTLPIYSIWDNRTRNRMLKYTPEHMHCFGTFWGPLI
APNTSFCCFQSFSASNPGFRIAATGTVLSVDESTEIVKKLKLVGTPWKIF
KNTAFIKDMFNSSLEIAKFEGAAIRTVSGIRGQIKRALSKPEGYFRATFE
DKILLSDIVILKAWYPVKPKQFYNPATNLIGWQSMRLTGEIRRAENIPTP
QNPNSTYRKIERPERHFNPLRVPKNLAAELPFKSQIVQTKPQKKETYMQK
RAVVVGREERKLRDLMQKLTTIRKEKIAKRKAKKEAQREKLKKELAEIEE
RRREKQKKEKKEFWEREGKKRK

>6rxu Chain C1 (length=1575) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacgg
guaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgc
cgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagac
uccuaaggcgcaagggaauaccccgugcgccggggguugggcucuguggg
ugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccg
guuggggaagcccuagcggcugaaccucucggucgggccuccucuugggg
cgccuaggcggugucuucgggucgcgugcagccucccguccucgccugcc
gacagcgcucuggggaauucaggaggggaaagcagaugugccccgcggcg
agacuggcgcaccgccggacgagcugcuggggcacgcggguacgcuagcc
gcacgauaguuaccugguugauucugcuagucauaugcuugucucaaaua
agccaugcgucuaaguauaagcaauuauacagcgaaacugcgaauggcuc
auuaaaucaguuaucguuuauuugauaguaccuuacuacauggauaaccg
ugguaauucuagagcuaauacaugcugaaaaucccgacuucggaagggau
guauuuauuagauuaaaaaccaaugcccuucggggcggugauucauaaua
acuucucgaaucgcacggccuuggccggcgaugguucauucaaauuucug
cccuaucaacuuucgacggcuggguauuggccagccguggugacaacggg
uaaggguuagggcucggagaaggagccugagaaacggcuacuacauccaa
ggaagggcaggcgcgcaaauuacccaaucccgacacggggagguagugac
aauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguac
aauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaauagcguauauugcucguaguugaaccu
gggccuagcccgccgguccgccucaccgcgugcacuggcugggcugggcc
ugauuaauagggacagucgggggcgucaguauucaauugucagaggugaa
auucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggau
guuuucauuaaucaggaacguaaacuauuagggaucggacggcguuuauu
uuugacccguucggcaccuuacgauaggaguauggucgcaaggcugaaaa
auugacggaagggcaccaccagggguggagccugcgcgcgcgcuacacug
acagagccagcgaguacucccuuggccgagaggcccggguaaacucuguc
gugcugaggaaucccuaguaagcgcaagucaucagcuugcguugauuacg
ucccugcccuuuguacacaccgcccgucgcuacuaccgauagaggaagua
ggucuccguaggugaaccugcggag

<<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>
>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<
....>>>>>.>>>>..>>>>>.>>.>>>>>.......<<<<<..<<<<<<
<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>.....
......<<<<<<.<<<.....>>>.>>>>>>...................
......<<<...>>>.....................<<<<<..<<<<<<<
<..<<...<<<<.....>>>>...>>..>>>>>.>>>>>>>>.....<<<
<<<...<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>
....>>>>>>...........................<<<<.<<<<<<<.
.<.<<<<<.....>>>>>.>..>>>>>..>>>>>><<<<.<.....>.>>
>>...........................<<.<<<<<<...<.<<.....
.<<<.<<<<<....<<....<<.........>>...>>.>>......<<<
.......<<<..<<..<<....<<<...............<<..<..<..
<<.......>>..>.....>>>........<<<<<..........>>>>>
<...<<<<<<..............<<<<<..>>>>>.........>>>>>
>.....>...<<<<.<<<<....>>>>>>>>....>>>...>>>>..>>>
.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>
...<<<<....>>>>.>>>.<<.<<<<........>>>>.>>.<.<<<..
>>>.>.>>>>>>.........<<<...<<<<.....>>>.>>>>...>..
.>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....<<..
<...........>..>>.........<<<<<<.......<<<....>>>.
.................>>>>>>..>>>>>>>>.<.<<...<<<.<<...
<<<<<<<<<<<<<<<<<.<<<......>>>...>>>>>>.>>>>>>>>>>
>..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<.....
.>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>>.>
>>.>>>...>>>...>>.>...........<<..<<<<<<<<.<<<....
...>>>>>>>>>>>..>>................................
...<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>>>.>>>.....<
<<<<<<..............<<.<<<<....>>>>.>>.....>>>>>>>
..........>>>>>>....<<<<<<<<.......>>>>>>>>......>
>...>>>>>>>............>>>>>..<<<<.<<......>>.>>>>
...<<<<<<<<<....>>>>>>>>>

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6rxu Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
Resolution	3.5 Å
Binding residue (original residue number in PDB)	R41 R45 R53 H55 V56 R91 S109 K110 G164 K178 P179 S180 K183 K190 Y198 Q199 G200 R217 H220 N221 V228 K230 N231 R233 P234 R324 R325 R326 Y739 K743 I826 K828 N853 R856 R858 K861 Y862 E865 H866 M867 K916 K917 K919 W925 F928 K929 N930 T931 F933 R953 V955 R959 K963 R964 L966 S967 R974 E978 K980 L982 L983 I986 I988 K990 R1020 P1028 Q1029 S1033 Y1035 R1043 H1044 F1045 N1046 R1049 N1053 S1062 T1067 P1069 Q1070 K1071 K1072 T1074 Y1075 Q1077 R1085 R1088 R1091 D1092 Q1095 T1098 T1099 K1104 K1107 R1108 K1111 K1112 R1116 W1142 E1143 G1146 K1147
Binding residue (residue number reindexed from 1)	R2 R6 R14 H16 V17 R52 S70 K71 G125 K139 P140 S141 K144 K151 Y159 Q160 G161 R178 H181 N182 V189 K191 N192 R194 P195 R277 R278 R279 Y411 K415 I498 K500 N525 R528 R530 K533 Y534 E537 H538 M539 K588 K589 K591 W597 F600 K601 N602 T603 F605 R625 V627 R631 K635 R636 L638 S639 R646 E650 K652 L654 L655 I658 I660 K662 R692 P700 Q701 S705 Y707 R715 H716 F717 N718 R721 N725 S734 T739 P741 Q742 K743 K744 T746 Y747 Q749 R757 R760 R763 D764 Q767 T770 T771 K776 K779 R780 K783 K784 R788 W814 E815 G818 K819

Enzyme Commision number

	Molecular Function
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0034511	U3 snoRNA binding

	Biological Process
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0030686	90S preribosome

PDB	RCSB:6rxu, PDBe:6rxu, PDBj:6rxu
PDBsum	6rxu
PubMed	31378463
UniProt	G0S445

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Structure of PDB 6rxu Chain CI Binding Site BS01