Structure of PDB 6hiw Chain CI Binding Site BS01

Receptor Information
>6hiw Chain CI (length=424) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQKLLSPRTARHARLFRLAGKLADSGSPGVPKSDGERLVWVNSHVRRDKD
ISLSQEEERIRELMMPLHGNLFYFREYPMYPGEYVPAEHNTLSSLRDELR
LDLTAQSLKEAWMRVSGGVYFQSVDEYYASVDGLDAEQIGEVLAALFPEL
NCYEAQALVQRTLECISRPVSAASRQLSRTITAEAVGLDNAPGHYTNFLE
WMGRLTETRAFKTEHALFEFSRRKFNRDDVRVMFENYRLMSKATLLADSA
DSYSHFYTVLKDFARKVAGQIGVRIDEAEVDPETGIAVGRGCADGEKYHF
TALLRENRDHNGIITVMGKPLSLVLDNKAWLMEMVLMPFDEANLDYRDFD
AHIVSEGHAMPSIANEIAAFALRMAVANALVKLIPLTRIPLKKSGLLSVD
RRRERGQFPGYLDGKKVKRRFAKR
Ligand information
>6hiw Chain CA (length=621) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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aauaguuaauaauaauuuauaauuuugauuagauuguuuuguuaaugcua
uuagauggguguggaaaaauaaaaaaaauaauuaauauauaucaauaaua
aauuaaauuaaucuauuagucagaaauggaugccagccguugcgguaauu
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uaaggauuauaaauugaaaguguuaauaucauaaucaaaauuuauuauuu
auauuaaauauguauguguagauaaaauaagaaauuaaaaagguauuguu
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....................<<<.......<<<<..............<.
..>..........................................<....
.<<...<<<.......>>>..>>........>........<<....>>..
..................................................
.................<<<.(...<<<<<.....<<..).>>.......
>>>>>>>>.......>>>>............<..................
.<.......>.....................>............<<<...
.>>>................<......>..>>>..<<.............
.<<<<<............................................
..................................................
.....................>>>>>..................>>....
<<.<<<..<<<<<<.....>>>>>>...>>>..>>....<<<<<<<<<..
..>>>>>>>>>..........
Receptor-Ligand Complex Structure
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PDB6hiw Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Resolution3.37 Å
Binding residue
(original residue number in PDB)		D313 E385 D419 R420 R421 R422 R424 L431 K435 K437 R438 R439 F440 R443
Binding residue
(residue number reindexed from 1)		D294 E366 D400 R401 R402 R403 R405 L412 K416 K418 R419 R420 F421 R424
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hiw, PDBe:6hiw, PDBj:6hiw
PDBsum6hiw
PubMed30213880
UniProtQ57W62

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