Structure of PDB 6hiw Chain CH Binding Site BS01

Receptor Information
>6hiw Chain CH (length=273) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKVYGAVPPLGAAQGHRLLHGKREREGSLFAVANDVKRDERLLRQQLNAL
LEEERMPMQARLQRNEAVSSHEAVPQTPLVDLPGVERRRDLPADPITRLF
FQHKGDHALYYGTYDKPSVQDDDRVQIEKRVPRRREENLYTPIYDFCHRI
REATEQRKRFVVVPSTIETRGCARVMHDHGLVAGFRDFHNDRAFAVELKY
FQGDSTINVIEPCSYDGRTEFEWSPKMMRRLLNTHGIHNRLVVYICRTAD
NRIIDHIHAVKENIGGRGLMMVH
Ligand information
>6hiw Chain CA (length=621) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaaauuauggucaauuguuaguauucauauuaauuuuuuuaaauguuuua
ucauuuuauaaagguuuauuuuugaaagauuuuuuguauaaaauuuuagg
aauaguuaauaauaauuuauaauuuugauuagauuguuuuguuaaugcua
uuagauggguguggaaaaauaaaaaaaauaauuaauauauaucaauaaua
aauuaaauuaaucuauuagucagaaauggaugccagccguugcgguaauu
ucuaugcuuuuaaauauuauacaauuaucauauuaaauuguuaaguguug
auuuaaccaauaaaaauauaaauaauuuuuauuuguuuuuaaacaccauu
agguauaugcaaauauaaaauuauaguaauuauaaauuauauuauauuau
auuuauucauauaauuaauaggauaauauuuguaguuuuugauaccauga
uaaggauuauaaauugaaaguguuaauaucauaaucaaaauuuauuauuu
auauuaaauauguauguguagauaaaauaagaaauuaaaaagguauuguu
gcccaccaauuuuuauaauaaaaauaacgugcaguaauuaauauauuuau
aaaaauauauuuuuuuuuuuu
....................<<<.......<<<<..............<.
..>..........................................<....
.<<...<<<.......>>>..>>........>........<<....>>..
..................................................
.................<<<.(...<<<<<.....<<..).>>.......
>>>>>>>>.......>>>>............<..................
.<.......>.....................>............<<<...
.>>>................<......>..>>>..<<.............
.<<<<<............................................
..................................................
.....................>>>>>..................>>....
<<.<<<..<<<<<<.....>>>>>>...>>>..>>....<<<<<<<<<..
..>>>>>>>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6hiw Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Resolution3.37 Å
Binding residue
(original residue number in PDB)		P66 M67 Q68 R70 L100 R143 E145 N147 R160 D187 R195 D196 Y224 K235 R238 R239 N272
Binding residue
(residue number reindexed from 1)		P57 M58 Q59 R61 L91 R134 E136 N138 R151 D178 R186 D187 Y215 K226 R229 R230 N263
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0000314 organellar small ribosomal subunit
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0020023 kinetoplast
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6hiw, PDBe:6hiw, PDBj:6hiw
PDBsum6hiw
PubMed30213880
UniProtQ388R7

[Back to BioLiP]