Structure of PDB 4v9r Chain CG Binding Site BS01

Receptor Information
>4v9r Chain CG (length=155) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQ
EKTGQEPLKVFKQAVENVKPRMEVRSRRVGGANYQVPMEVSPRRQQSLAL
RWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAY
AHYRW
Ligand information
>4v9r Chain CA (length=1503) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga
caugcaagucgugcgggccgcgggguacuccguggucagcggcggacggg
ugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaa
cucgggcuaaucccccauguggacccgccccuugggguguguccaaaggg
cuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggggu
aauggcccaccaaggcgacgacggguagccggucugagaggauggccggc
cacaggggcacugagacacgggccccacuccuacgggaggcagcaguuag
gaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagga
agaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacg
aggggacugacgguaccgggguaauagcgccggccaacuccgugccagca
gccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaa
agggcguguaggcggccuggggcgucccaugugaaagaccacggcucaac
cgugggggagcgugggauacgcucaggcuagacggugggagaggguggug
gaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgau
ggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgug
gggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcg
cgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgc
cgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggggg
cccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaac
cuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugcc
ccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgug
ccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuag
uugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcggg
aggaaggaggggacgacgucuggucagcauggcccuuacggccugggcga
cacacgugcuacaaugcccacuacaaagcgaugccacccggcaacgggga
gcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgac
cccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcgguga
auacguucccgggccuuguacacaccgcccgucacgccaugggagcgggc
ucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggccc
gugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug
gau
.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<
<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<
<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<.....
.>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<
<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<..
.....>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>
.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>.
.......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<..
....<<<<....>>>>.....>>>>....<<<<<........<<<<....
.>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.
)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>
>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.
...<<<<<<<.<..<<<......>>>.....>.>>>>>>>..........
.<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<
<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<
<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>
.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<
<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>......
....<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<
<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<
<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<
..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>
........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>
>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..
>>....>>>.....>>>>>>>...........<<<<<<<........>>>
>>>>..........>>>>>>....<<<<<<<..........>>>>>>>..
....>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<
<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>
>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.
...
Receptor-Ligand Complex Structure
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PDB4v9r The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		A2 R3 R4 R6 A7 R10 N28 K29 I30 M31 R32 D33 G34 K35 K36 L38 R41 G82 R94 R95 S98 R102 N109 R114 R115 A116 R119
Binding residue
(residue number reindexed from 1)		A1 R2 R3 R5 A6 R9 N27 K28 I29 M30 R31 D32 G33 K34 K35 L37 R40 G81 R93 R94 S97 R101 N108 R113 R114 A115 R118
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v9r, PDBe:4v9r, PDBj:4v9r
PDBsum4v9r
PubMed24412368
UniProtP17291|RS7_THET8 Small ribosomal subunit protein uS7 (Gene Name=rpsG)

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