Structure of PDB 4v8a Chain CD Binding Site BS01

Receptor Information
>4v8a Chain CD (length=208) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRYIGPVCRLCRREGVKLYLKGERCYSPKCAMERRPYPPGQHGQKRARRP
SDYAVRLREKQKLRRIYGISERQFRNLFEEASKKKGVTGSVFLGLLESRL
DNVVYRLGFAVSRRQARQLVRHGHITVNGRRVDLPSYRVRPGDEIAVAEK
SRNLELIRQNLEAMKGRKVGPWLSLDVEGMKGKFLRLPDREDLALPVNEQ
LVIEFYSR
Ligand information
>4v8a Chain CA (length=1498) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaag
acaugcaagucgugcgggccgcgggcccguggucagcggcggacggguga
guaacgcgugggugaccuacccggaagagggggacaacccggggaaacuc
gggcuaaucccccauguggacccgccccuugggguguguccaaagggcuu
ugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaau
ggcccaccaaggcgacgacggguagccggucugagaggauggccggccac
aggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaa
ucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaaga
agcccuucgggguguaaacuccugaacccgggacgaaacccccgacgagg
ggacugacgguaccgggguaauagcgccggccaacuccgugccagcagcc
gcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagg
gcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgu
gggggagcgugggauacgcucaggcuagacggugggagagggugguggaa
uucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggc
gaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgugggg
agcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgc
uaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgc
cuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggccc
gcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuu
accaggccuugacaugcuagggaacccgggugaaagccuggggugccccg
cgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccg
ugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguug
ccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggagg
aaggaggggacgacgucuggucagcauggcccuuacggccugggcgacac
acgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcu
aaucgcaaaaaggugggcccaguucggauuggggucugcaacccgacccc
augaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaaua
cguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucu
acccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgug
acuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg
......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<
<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<..
.....<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>
>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<..
.>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.....
..>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>
.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>....
....<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.....
.<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>
>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))
>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....
<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>
>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....
<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<
....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<..
.<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<
..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>
>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<
<.<<.<<<<<<..<<<<<<<<<<......<<........>>.........
.<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<..
....>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<.
...>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...
<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>...
.....>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>
>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>.
...>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>
>>.........>>>>>>....<<<<<<<..........>>>>>>>.....
.>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<
<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>.
.>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB4v8a The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge b2a of the ribosome.
Resolution3.2 Å
Binding residue
(original residue number in PDB)
G2 I5 V8 C9 R10 R13 R14 K22 R25 R35 R36 Y38 P40 G41 Q42 H43 Q45 S52 Y54 L58 Q62 R66 E72 R73 Q74 N77 S113 R115 Q116 Q119 H123 H125 D134 L135 S137 L155 E156 S208
Binding residue
(residue number reindexed from 1)
G1 I4 V7 C8 R9 R12 R13 K21 R24 R34 R35 Y37 P39 G40 Q41 H42 Q44 S51 Y53 L57 Q61 R65 E71 R72 Q73 N76 S112 R114 Q115 Q118 H122 H124 D133 L134 S136 L154 E155 S207
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:4v8a, PDBe:4v8a, PDBj:4v8a
PDBsum4v8a
PubMed22240456
UniProtP80373|RS4_THET8 Small ribosomal subunit protein uS4 (Gene Name=rpsD)

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