Structure of PDB 7q5t Chain CCC Binding Site BS01

Receptor Information
>7q5t Chain CCC (length=261) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHG
RKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFN
RPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLI
ATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLL
HEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVP
CQKIGTQGNVN
Ligand information
>7q5t Chain HHH (length=18) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GVYTGLSTRNQETYETLK
Receptor-Ligand Complex Structure
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PDB7q5t The tandem SH2 domains of SYK
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R22 R42 H63 Y64 T65 A77 G78 G98 L99 R175 R195 R197 H215 Y216 R217 E230 G231 K232 K247 G250
Binding residue
(residue number reindexed from 1)		R14 R34 H55 Y56 T57 A69 G70 G90 L91 R167 R187 R189 H207 Y208 R209 E222 G223 K224 K239 G242
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5t, PDBe:7q5t, PDBj:7q5t
PDBsum7q5t
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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