Structure of PDB 6rxt Chain CC Binding Site BS01

Receptor Information

>6rxt Chain CC (length=387) Species: 209285 (Thermochaetoides thermophila)

VVNFLLFESAVGFSLFEVVHQADTVGLELPEVKDAMKTLDKFGKMVKLRS
FNPWTSAAQGLEAINLISEGIMPEYLKSALEMNLPQTSGKKSKVVLGVAD
KKLAGEITAAFPGVQCEAADTSEVVAALLRGIRTHANKLHKSLQEGDIGR
AQLGLGHAYSRAKVKFSVHKNDNHIIQGIATLDALDKSINQGAMRVREWY
GWHFPELIRIVSDNITYAKVVLAIGNKSSLTDESVDDLANVLNQDQDKAL
AIIQAAKVSMGQDISEVDLQMVRDLASNVTSMADYRRILAESLDKKMSEV
APNLQVILGTPVAARLIAHAGSLTNLAKYPASTLQILPKVKGRISRYLAN
KCSIASRIDNFSEKPTRHFGEVLRQQLEQRLEWYAKG

Ligand information

>6rxt Chain C1 (length=1152)

ggggggauguccgggucgcccugggcaccucucccggcagccuucgcggg
cagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacgg
guaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgc
cgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagac
uccuaaggcgcaagggaauaccccgugcgccggggguugggcucuguggg
ugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccg
guuggggaagcccuagcggcugaaccucucggucgggccuccucuugggg
cgccuaggcggugucuucgggucgcgugcagccucccguccucgccugcc
gacagcgcucuggggaauucaggaggggaaagcagaugugccccgcggcg
agacuggcgcaccgccggacgagcugcuggggcacgcggguacgcuagcc
gcacgauaguuaccugguugauucugcuagucauaugcuugucucaaaua
cccaaucccgacacggggagguagugacaauaaauacugauacagggcuc
uuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgagga
acaauuggagggcaagucuggugccagcagccgcgguaauuccagcucca
auagcguauauugcucguaguugaaccugauuaauagggacagucggggg
cgucaguauucaauugucagaggugaaauucuuggauuuauugaagacua
acaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacguaa
acuauuagggaucggacggcguuuauuuuugacccguucggcaccuuacg
auaggaguauggucgcaaggcugaaaaauugacggaagggcaccaccagg
gguggagccugcgcgcgcgcuacacugacagagccagcgaguacucccuu
ggccgagaggcccggguaaacucugucgugcugaggaaucccuaguaagc
gcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgc
ccgucgcuacuaccgauagaggaaguaggucuccguaggugaaccugcgg
ag

<<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>
>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<
....>>>>>.>>>>..>>>>>.>>.>>>>>.......<<<<<..<<<<<<
<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>.....
......<<<<<<.<<<.....>>>.>>>>>>...................
......<<<...>>>.....................<<<<<..<<<<<<<
<..<<...<<<<.....>>>>...>>..>>>>>.>>>>>>>>.....<<<
<<<...<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>
....>>>>>>...........................<<<<.<<<<<<<.
.<.<<<<<.....>>>>>.>..>>>>>..>>>>>><<<<.<.....>.>>
>>...........................<<.<<<<<<...<.<<..<.<
<<...<<<<.....>>>.>>>>..>>...>.>....<<<<<<<<<<<<<<
....>>>>>>>>>.>>>>>.....<<..<...........>..>>.....
....<<<<<<.......<<<....>>>..................>>>>>
>..>>>>>>>>.<.<<...<<<.<<.....>>....<<<<<<.<<...<<
<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.
......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>....
.......<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>.....
..............................<<<<<<<<<<<<..<<.<<<
<<<..<<<.<<<..>>>.>>>.....<<<<<<<..............<<.
<<<<....>>>>.>>.....>>>>>>>..........>>>>>>....<<<
<<<<<.......>>>>>>>>......>>...>>>>>>>............
>>>>>..<<<<.<<......>>.>>>>...<<<<<<<<<....>>>>>>>
>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rxt Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
• Resolution: 7.0 Å
• Binding residue (original residue number in PDB): H22 L41 K46 Q88 S90 K92 K93 S94 K140 L141 K143
• Binding residue (residue number reindexed from 1): H20 L39 K44 Q86 S88 K90 K91 S92 K138 L139 K141

Gene Ontology

Molecular Function

• GO:0030515 snoRNA binding

Cellular Component

• GO:0031428 box C/D methylation guide snoRNP complex
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:6rxt, PDBe:6rxt, PDBj:6rxt
• PDBsum: 6rxt
• PubMed: 31378463
• UniProt: G0S2U4