Structure of PDB 4v7m Chain CC Binding Site BS01

Receptor Information
>4v7m Chain CC (length=205) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAG
LARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVAL
NVQEVQNPNLSAPLVAQRVAEQIRRFAVRRAIKQAVQRVMESGAKGAKVI
VSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAYI
FLGEV
Ligand information
>4v7m Chain CA (length=1493) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgcguggucagcggcggacgggugaguaacg
cgugggugaccuacccggaagagggggacaacccggggaaacucgggcua
aucccccauguggacccgccccuugggguguguccaaagggcuuugcccg
cuuccggaugggcccgcgucccaucagcuaguuggugggguaauggccca
ccaaggcgacgacggguagccggucugagaggauggccggccacaggggc
acugagacacgggccccacuccuacgggaggcagcaguuaggaaucuucc
gcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccu
ucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacug
acgguaccgggguaauagcgccggccaacuccgugccagcagccgcggua
auacggagggcgcgagcguuacccggauucacugggcguaaagggcgugu
aggcggccuggggcgucccaugugaaagaccacggcucaaccguggggga
gcgugggauacgcucaggcuagacggugggagagggugguggaauucccg
gaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggc
agccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaa
ccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuagguc
ucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccugggg
aguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaa
gcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccagg
ccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggg
gagcccuagcacaggugcugcauggccgucgucagcucgugccgugaggu
guuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcg
guucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggag
gggacgacgucuggucagcauggcccuuacggccugggcgacacacgugc
uacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgc
aaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaag
ccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucc
cgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccga
agucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggg
gcgaagucguaacaagguagcuguaccggaaggugcggcugga
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<
.<<<..<<<..<<..<<<<<..>>>>>..>>>>>......<<.......<
<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>...
..>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.
>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>
>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<
.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<
<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<.
...>>>>.....>>>>....<<<<<........<<<<.....>>>>....
......>>>>>......<<<<<(((...<<<<<.....<<.)))>>....
...>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<..
.<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....
>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<
<.<..<<<......>>>.....>.>>>>>>>...........<<....>>
.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...
<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<
<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.
.....<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<
<<<<<..<<<<<<<<<<......<<........>>..........<<<<<
<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>>.
...>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>
..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<
<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>
>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>
>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>
.....>>>>>>>...........<<<<<<<........>>>>>>>.....
.....>>>>>>....<<<<<<<..........>>>>>>>......>>...
>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..
.<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>
>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...
Receptor-Ligand Complex Structure
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PDB4v7m The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.
Resolution3.45 Å
Binding residue
(original residue number in PDB)		G2 N3 K4 I5 F10 K26 K27 R127 S154 G155 R156 E161 A163 G171 R172 P174 H176 T177 L178 R179 R190 T192 Y193 G194 V195 K199
Binding residue
(residue number reindexed from 1)		G1 N2 K3 I4 F9 K25 K26 R125 S152 G153 R154 E159 A161 G169 R170 P172 H174 T175 L176 R177 R188 T190 Y191 G192 V193 K197
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v7m, PDBe:4v7m, PDBj:4v7m
PDBsum4v7m
PubMed20154709
UniProtP80372|RS3_THET8 Small ribosomal subunit protein uS3 (Gene Name=rpsC)

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