Structure of PDB 4v8a Chain CB Binding Site BS01

Receptor Information
>4v8a Chain CB (length=229) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFR
FIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFK
TISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLK
RLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDD
AIRSIQLILSRAVDLIIQARGGVVEPSPS
Ligand information
>4v8a Chain CA (length=1498) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaag
acaugcaagucgugcgggccgcgggcccguggucagcggcggacggguga
guaacgcgugggugaccuacccggaagagggggacaacccggggaaacuc
gggcuaaucccccauguggacccgccccuugggguguguccaaagggcuu
ugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaau
ggcccaccaaggcgacgacggguagccggucugagaggauggccggccac
aggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaa
ucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaaga
agcccuucgggguguaaacuccugaacccgggacgaaacccccgacgagg
ggacugacgguaccgggguaauagcgccggccaacuccgugccagcagcc
gcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagg
gcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgu
gggggagcgugggauacgcucaggcuagacggugggagagggugguggaa
uucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggc
gaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgugggg
agcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgc
uaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgc
cuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggccc
gcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuu
accaggccuugacaugcuagggaacccgggugaaagccuggggugccccg
cgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccg
ugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguug
ccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggagg
aaggaggggacgacgucuggucagcauggcccuuacggccugggcgacac
acgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcu
aaucgcaaaaaggugggcccaguucggauuggggucugcaacccgacccc
augaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaaua
cguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucu
acccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgug
acuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg
......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<
<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<..
.....<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>
>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<..
.>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.....
..>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>
.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>....
....<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.....
.<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>
>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))
>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....
<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>
>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....
<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<
....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<..
.<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<
..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>
>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<
<.<<.<<<<<<..<<<<<<<<<<......<<........>>.........
.<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<..
....>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<.
...>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...
<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>...
.....>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>
>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>.
...>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>
>>.........>>>>>>....<<<<<<<..........>>>>>>>.....
.>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<
<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>.
.>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB4v8a The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge b2a of the ribosome.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		K22 P26 G99 T103 N104 R111 K133 I172 E176 K179
Binding residue
(residue number reindexed from 1)		K16 P20 G93 T97 N98 R105 K127 I166 E170 K173
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v8a, PDBe:4v8a, PDBj:4v8a
PDBsum4v8a
PubMed22240456
UniProtP80371|RS2_THET8 Small ribosomal subunit protein uS2 (Gene Name=rpsB)

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