Structure of PDB 8i9r Chain CA Binding Site BS01

Receptor Information
>8i9r Chain CA (length=260) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRSNIIAERKNKQRVLVLSSRGVTYRHRHLLNDLASMLPHGRKDAKFDTK
SRLYELCELAELYNCNNVLFFEARKGKDLYMWFSKVPNGPTVKFYAQNLH
TMEELHFQGNCLKGSRPILSFDAAFEQEPYLKVIKELFLHTFGVPQGHKK
SKPFIDHVLSFSVADGKIWVRNYEIREVEKVKTDINLIEIGPRFVLTPII
IQEGSFGGPILYENKRFISPNKIRAELRKAKAARHHARMEQQRDLLARKR
QDLDTRELFA
Ligand information
>8i9r Chain C1 (length=2048) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaaggugagag
cuucggcgcaucaucgaccgauccugauguauucggauggauuugaguag
gagcguuaagccuuggacccgaaagauggugaacuaugcuugagcauggg
ggcgaaagacuaaucgaaccaucuaguagcugguuaccgccgaaguuucc
cucaggauagcagugucgaccuucaguuuuaugagguaaagcuuuaaaua
uguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucga
cacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccg
aacgcgggguuaaggugccggaguggacgcucacaaaaggcguuaguaca
ucuuauguacuagcccugggcgcucaagcgucccacccauaccccgcccu
caggguagaaacgaugcccugaggaguaggcggccguggaggucagugac
gaagccuagggcgugagcccgggucgaacggccucuagugcagaucuugg
ugguaguagcaaauacuucaaugagaaggugaacagccucugugauagaa
caauguagauaagggaagucacugucccuaucuacuaucuagcgaaacca
cagccaagggaacgggcuuggcaaaaucagcggggaagacccuguugagc
uugacucuaguuugacauugugaaaagacauaggagguguagaauaggug
ggagcuucggcgccagugaaauaccacuacuccuauuguuuuuuuacuua
uucaaugugaagacauugucagguggggaguuggcggcacaucugugcag
guguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaag
gguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaa
guguggccuccuuuagucccucgaaauuugaggcuagaggagaaaaguua
ccacagggaugaccgucgugagacagguuaguucccuacugauacucguc
gcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauug
guuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcugg
auuccaugccagaacgcgacgauaacccgcacgguagacguauaagaaua
ggcuccggccucguauccuagcaggcgauuccuccgccggccucgaagug
gccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaaucc
uuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagc
cuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc
.........................<<<<<.....<......>......>
>>>>...........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>..................................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<<....<<.<<<<<<<<<<.<<.<<<
<<<....>>>>>>>>...>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>
>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<........>>>><<<<<<...<<<<
<<<<<.<<<<..<<<...<<<<.....>>>>...>>>.....<<<<<..<
<....>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>..
..>>>>.>>>>>>>>>.<<.<..<<<<<<<...<<<<<<<..>>>>>.>>
..<<<..(((((.>>>.>>>>>>...>..>.>>...<<<<<......<<<
....>>>..<<<<<<<<<<....<<.<<<<<<<.<.<.........>.>.
>>>>>....<<..<<<<.<......>>>>>.>>.......>>>>..>>>>
>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>
...<<<<<<<...<<<(((.....<<<<<<.......<<<..<<<<<<<<
<...>>>>>>>>>.>>>.)))......>>>>>>.>>>...>>>>>>><<<
<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<...
...<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>
><<.....<<.......<<<..<<<............>>>..>>><<<<.
....<<<<<<.<<<<<<<<.>>>.>>>>>>>>>>>..>>>>>>....>>.
(..<<<<<......).>>>>>......<<<.<<......<<<<<<.<<<<
<<.<<<<<..<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<
<......................>>>>>.>>>>>>>.>>>>>>>>>>...
<<<<...>>>>.....>>>>>>>...>>>>>.<<<...<<<<<<<..>>>
>>>>.....<<<<<<<...<<<<<<.......>>>>>>.....<<.....
.>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>>.<<<....
>>>..>>>.<<<<<<<..<<<<<<...>>>>>>>>>>>>>....>>>>>.
>.>>>>>>....<<<<<....>>>.>>.))))).>>..>>>....<<<<<
<<..<<<<...<<<<<.................>>>>>..<<<<<...<<
<<.<<<<<<<<<<<<<....>>>>>..>>>>>>>>>>>>..>>>>>.<<<
<.>>>>.>>>>....>>>>>>>...<<<<<...<<......<<.......
<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>
>>>>.>>>....>>>>..............>>....>>>>>...<<<<<<
<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<
......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8i9r Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		G43 V44 T45 K67 T70 S72 R73 L74 E93 R95 K96 K114 I244 E257 S263 N265 H279 R282 Q285 L289
Binding residue
(residue number reindexed from 1)		G22 V23 T24 K46 T49 S51 R52 L53 E72 R74 K75 K93 I200 E213 S219 N221 H235 R238 Q241 L245
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006364 rRNA processing
Cellular Component
GO:0005730 nucleolus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8i9r, PDBe:8i9r, PDBj:8i9r
PDBsum8i9r
PubMed37129998
UniProtG0RXZ3

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