Structure of PDB 5ndv Chain C9 Binding Site BS01

Receptor Information
>5ndv Chain C9 (length=137) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDVAAQDFINAYASFLQRQGKLEVPGYVDIVKTSSGNEMPPQDAEGWFYK
RAASVARHIYMRKQVGVGKLNKLYGGAKSRGVRPYKHIDASGSINRKVLQ
ALEKIGIVEISPKGGRRISENGQRDLDRIAAQTLEED
Ligand information
>5ndv Chain 2 (length=1712) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagguuguaauuggaau
gaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggu
gccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguug
caguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauu
uccaacggggccuuuccuucuggcaccaggacuuuuacuuugaaaaaauu
agaguguucaaagcaggcguauugcucgaauauauuagcauggaauaaua
gaauaggacguuugguucuauuuuguugguuucuaggaccaucguaauga
uuaauagggacggucgggggcaucaguauucaauugucagaggugaaauu
cuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguu
uucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgu
cguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuu
uaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggg
gggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcacc
accaggaguggagccugcggcuuaauuugacucaacacggggaaacucac
cagguccagacacaauaaggauugacagauugagagcucuuucuugauuu
ugugggugguggugcauggccguucuuaguugguggagugauuugucugc
uuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagc
auuugcugguuauccacuucuuagagggacuaucgguuucaagccgaugg
aaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgc
acgcgcgcuacacugacggagccagcgagucuaaccuuggccgagagguc
uugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauua
uugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguu
gauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauuga
auggcuuagugaggccucaggaucuggagcggagaauuuggacaaacuug
gucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccug
cggaaggaucau
...<<<<<...[[[[>>>>>[[[[.((((((................[[[
.[[[..<<....<<....<............>...>>.>>......{{..
......[[[..{{..{{....[[[..................<.....<<
.<<<.....>>>.>>......>.........<<<<<..<......>..>>
>>>[...((((((......<<<<<<<<<<<....>>>.............
.)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}
}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<.......
...>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<
.....>>>..>>>...............<<<<<.......>>.>>>....
..<<..<...........>..>>.........<<<<<((....<.<<<<.
....<<..))>>.......>>>>>>>>>>..))))))]]]].........
[[[{{.......{{...[[[.{{....<<<<<<.<<<<............
..>>>>.>>>>>>.....<<<<<..>>>>>....<<<<<.<<.......<
<...<.......>..<<<<...>>>>....>>......>>.>>..>>>..
.......[[[..((((((((....>>>>>>>>.)))))))).]]].....
}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>
>......>.>>>>>.>.>>.......<<....>>...>>>>..>.>>>>.
>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>
>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<....
....>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<
<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..
<<.<<<<<<..<<<.<<<<........<<........>>..........<
<<<<.<....<<<<<........<<.<<<........>>>.>>......>
>>>>.<.<<.<<<..<<<<<<<<.....<<<.<<<<<....>>>...<<<
......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<
....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>..
.....>>>>>.....>>.>>>...>.>>>>>>>>....>.>>>>>.....
.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>
..>>....>>.......>>>>>>>...........<<<<<<.........
.>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>
......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<
<<<<<<.<<<..<.<<......<<<.....>>>......>>.>..>>>.>
>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>
>>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ndv Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Resolution3.3 Å
Binding residue
(original residue number in PDB)
R7 Y33 K38 T39 S41 N43 E44 M45 P47 Q48 S60 R63 H64 R68 K69 G72 V73 G74 K75 K78 L79 Y80 G81 A83 K84 R86 G87 V88 R89 P90 Y91 K92 H93 S97 G98 S99 R102 Q106 G120 G121 R122 E126 Q129 R130 D133
Binding residue
(residue number reindexed from 1)
R1 Y27 K32 T33 S35 N37 E38 M39 P41 Q42 S54 R57 H58 R62 K63 G66 V67 G68 K69 K72 L73 Y74 G75 A77 K78 R80 G81 V82 R83 P84 Y85 K86 H87 S91 G92 S93 R96 Q100 G114 G115 R116 E120 Q123 R124 D127
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000054 ribosomal subunit export from nucleus
GO:0006412 translation
GO:0042254 ribosome biogenesis
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:5ndv, PDBe:5ndv, PDBj:5ndv
PDBsum5ndv
PubMed29208708
UniProtP07280|RS19A_YEAST Small ribosomal subunit protein eS19A (Gene Name=RPS19A)

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