Structure of PDB 6gzx Chain C4 Binding Site BS01

Receptor Information
>6gzx Chain C4 (length=206) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAG
LARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVAL
NVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKV
IVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAY
IFLGEV
Ligand information
>6gzx Chain A4 (length=1506) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
uggauc
....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<......<<.
......<<<..<<...........................>>>>>.....
.<<.......<<<<<<<...<<...<<..<....<<<.......<<<...
...>>>........>>>.....<<<<..<<........>>..>>>>...<
<.......>>...>..>>..>>.>>>>>>><<<..........<<<<<<<
.......>>>>>>>..........>>>..<<<<<<<<....>>>...>>>
>>.>>..<.<<............>.>>..<<<<<..>>>>>.......>>
......<<.<<<.....<<......>>...>>>>>.>.>>>>>>..<<<<
......<.<<.....>>>.....>>>>....<<<<<........<<<...
...>.>>..........>>>>>......<<<<..(....<<<<<......
...)..........>>>>>.>>>>..>>>>>>>>>...........<<((
.....<<<<...<<<.<<<<<..<<<<<<<<.........<<<<<<....
.>>>>>>.......>>>>>..>>>.>>>>>..........<...<<<<<<
<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>........
...<......>.>>>>>>>..>...........>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<.<<<<...>>>>.>>>>>...<<..))>>.....>>>>
>>.>>..........<<<<......>>>>.........))).].<.<..<
<<<<<<.....<<<<....<<<<<<<........<<........>>....
.......<<<............<......<.<............>>....
..................>........<<...<<<<.<..<.....<<<<
.<<<....>>>..<<<<......>>>>...>>>>........<<..<<.<
<....<....<.......>..>.....>>.>>..................
..........>>.......>...>.>...>>>.>>.........>>>...
....>>>>>>>......<<<.........<<...<<...<<.......>>
..>>.....>>.........>>>...........<<<<<<<........>
>>>>>>...........>>>>......<<<<<<..........>>>>>>.
...........>>>>>>>.>..>........<<...<<<<.<<<..<<.<
<<<..<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>..>>>
>.>>..>>>.>>>>....>>.........<<<<.<<<<....>>>>.>>>
>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gzx Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Resolution4.57 Å
Binding residue
(original residue number in PDB)		N3 K4 F10 K27 R156 E161 G171 R172 V173 P174 H176 L178 Y193 V195 G197
Binding residue
(residue number reindexed from 1)		N2 K3 F9 K26 R155 E160 G170 R171 V172 P173 H175 L177 Y192 V194 G196
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6gzx, PDBe:6gzx, PDBj:6gzx
PDBsum6gzx
PubMed30301898
UniProtP80372|RS3_THET8 Small ribosomal subunit protein uS3 (Gene Name=rpsC)

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