Structure of PDB 6zvk Chain C2 Binding Site BS01

Receptor Information
>6zvk Chain C2 (length=86) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK
Ligand information
>6zvk Chain e2 (length=3920) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggguccggccgugucggcgg
cccggcggaucuuucccgccccccguggggucggcgggggaccguccccc
gaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggg
gggccccgcgggaccgaaaccccccccgaguguuacagcccccccggcag
cagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcu
cuccccccucccggcgcccacccggggcgcgccggcgucuccucgugggg
gggccgggccaccccucccacggcgcgaccgcucucccaccccucgucgg
ggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgg
gcccgggggagguucucucggggccacgcgcgcgucccccgaagaggggg
acggcggagcgagcgcacggggucggcggcgacgucggcuacccacccga
cccgucuugaaacacggaccaaggagucuaacacgugcgcgagucggggg
cucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucg
ccggccgaggugggaucccgaggccucuccaguccgccgagggcgcacca
ccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacgug
uuaggacccgaaagauggugaacuaugccugggcagggcgaagccagagg
aaacucugguggagguccguagcgguccugacgugcaaaucggucguccg
accuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucc
cuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcacc
cccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggc
cgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggc
ucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuug
guaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcc
cgaugccgacgcucaucagaccccagaaaagguguugguugauauagaca
gcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaac
ucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgg
gcccauacccggccgucgccggcagucgagaguggacgggagcggcgggg
gcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcg
acgaguaggagggccgcugcggugagccuugaagccuagggcgcgggccc
ggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaa
acgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcagu
ugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagg
gacgggcgauggccuccguugcccucggccgaucgaaagggagucggguu
cagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagu
gcgguaacgcgaccgaucccggagaagccggcgggagccccggggagagu
ucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgag
agaggggcccgugccuuggaaagcgucgcgguuccggcggcguccgguga
gcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgcc
gggccguacccauauccgcagcaggucuccaaggugaacagccucuggca
uguuggaacaauguagguaagggaagucggcaagccggauccguaacuuc
gggauaaggauuggcucuaagggcugggucggucgucggccggcgccuag
cagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaa
aacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucu
gcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaa
acggcgggaguaacuaugacucucuuaagguagccaaaugccucgucauc
uaauuagugacgcgcaugaauggaugaacgagauucccacugucccuacc
uacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcg
gggaaagaagacccuguugagcuugacucuagucuggcacggugaagaga
caugagagguguagaauaagugggaggcccccggcgcccccccggugucc
ccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaa
auaccacuacucugaucguuuuuucacugacccggugaggcgggggggcg
agccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccgg
ccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggg
gcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucaggg
aggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuug
auuuucaguacgaauacagaccgugaaagcggggccucacgauccuucug
accuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaa
cuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuuc
gaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggau
uguucacccacuaauagggaacgugagcuggguuuagaccgucgugagac
agguuaguuuuacccuacugaugauguguuguugccaugguaauccugcu
caguacgagaggaaccgcagguucagacauuugguguaugugcuuggcug
aggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccu
cuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagcc
ucgguuggccucggauagccggucccccgccuguccccgccggcgccgcg
cgccgggaccgggguccggugcggagugcccuucguccugggaaacgggg
cgcggccggagaggcggccgcccccucgcccgucacgcaccggccguucg
uggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucggg
guuucguacguagcagagcagcucccucgcugcgaucuauugaaagucag
cccucgacacaaggguuugu
.........................<<<<<<<....<......>.....>
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>>>>>>..[[[....<<<...<<<<<<<<<<<...>>>>>>>.>>>>...
..>>>....<<<<<<<<<....<<<<<<<<.<.<....<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>>.>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....(((((..<<<<<<)))))..]]]..................
................<<....>>...............<<<......>>
>..................................<<<<<<<<..<<<..
....<<<<<<<<.<<<.....<<<<<<<<<<<...<<<.....<<<<.<<
....<<<<.<<<..<<<<<<<<<<..>>>>..>>>>>>>>>>>>>>>.>>
>>.......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<
<<..<<<<<<<<<<.<<<....<.....<<<<.<<<<......<<<<<<<
.<....<..>...........>>..>>>>>>.......>>>>.>>>>...
.......>.>>>...>>>>>>>>>>....................<<<<.
..<<<<<<<..<<<<<....<<<.>>>..>>>>>.<<......>>.>>>>
>>>.....<<.<<<<.<<<<<<<<<<<<<<<<<.......<<<<.....>
>>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>
>...>.>>>...........>.>.........<<<<<<<<.....>>>>>
>>>.........>>>>.......>>.>>>>>....>>>...>>>>>>>>.
.<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<
<<........>>>>.....>>>...<<....>>...<<<<<<<......>
>>>>>>..<<<<<...<<<..<<<...(((..[..>>>..>>>....>>>
>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>
>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<.
...>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>...
.>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<
<<<<....<.<<<....>>>.><<<<<<<<<<..................
.........<<.<<<<<<<<<...<<<....<<<..<.<<<..<....<.
........>...>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<
<<........>>>>>>>>>...>>.>>>>>>>>>.>>>..<<<<.<<<<<
.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((
.......<<<<<.....<<..........<<<.<<<<<<<<<<.......
<<....<<....<<.........>>....>>.......<.<<......>>
.>....>>...>>>>>>>>>>>>>..........))).>>...>>>>>..
>>>...>>>>>>><<<<<<.<<<............].)))..........
............................................>>>>>>
>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>
>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<
<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....
>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........
<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<..
......>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..
<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<.
.{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>...
..>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...
>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>
>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>.
...<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..
>>.....>>>>><<.<<<<<<<<<<<..<<<<<<<.>>>>>>>.......
>>>>>..>>>>>>.>>............<<<<<<<<<..<<<........
.>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..
<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..
>>>>><<<<<<.......>>>>>>........<...........<<<<<.
......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>
>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..
{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<.<<
<...............................<<<<.<<<<<<<<.<<<<
<.....>>>>>>>>>>>..>>...>>>>......................
.................>>>.>>>>>>...<<<<<.....<<<<..<<.<
<<<<<<..>>>>>>>>>..............<<<<<<<<<<<.....>>>
>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<...
..>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<
<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..
<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((
..(((..>>>>>>.)))))))))..........]]]]..}}]]]].....
..<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>...
....<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<..
.......>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>
.>>>>....}}..}}}.]]]]].....<<<<<<....<<<..<.<<<<<.
................>>>>>.><<<<....<<<<....<<.<<<<<<.}
}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<........
...>>>>>...>>>>>.>>>.....>>>>>>.....<<<<<<<.....<<
<.....<<.........<<<<<..<.<<....<<<<<.<<<<<..>>>.>
>...>>>>>..>>>.>>>>>........>>....<<..<<<<....<<<<
.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............
..>>>....>>>>>>><<<<<.<.............>....<<.<<<<<<
<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....
>>>>.>>>.>>..>>>>>..
Receptor-Ligand Complex Structure
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PDB6zvk The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
Resolution3.49 Å
Binding residue
(original residue number in PDB)
T2 K3 G4 T5 S6 F8 G9 K10 R11 R12 N13 T15 H16 K25 H28 Q30 R43 K44 R45 K46 Y47 N48 W49 S50 K52 R55 R56 T59 Y71 R75 E80
Binding residue
(residue number reindexed from 1)
T1 K2 G3 T4 S5 F7 G8 K9 R10 R11 N12 T14 H15 K24 H27 Q29 R42 K43 R44 K45 Y46 N47 W48 S49 K51 R54 R55 T58 Y70 R74 E79
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6zvk, PDBe:6zvk, PDBj:6zvk
PDBsum6zvk
PubMed33296660
UniProtU3KPD5|RL37_RABIT Large ribosomal subunit protein eL37 (Gene Name=RPL37)

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