Structure of PDB 7tns Chain C1 Binding Site BS01

Receptor Information

>7tns Chain C1 (length=426) Species: 508771 (Toxoplasma gondii ME49) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MREIVHVQGGQCGNQIGAKFWEVISDEHGIDPTGTYCGDSDLQLERINVF
YNEATGGRFVPRAILMDLEPGTMDSVRAGPFGQLFRPDNFVFGQTGAGNN
WAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQITHSLGGGTGSGMGTL
LISKVREEYPDRIMETFSVFPSPKVSDTVVEPYNATLSVHQLVENADEVQ
VIDNEALYDICFRTLKLTTPTYGDLNHLVSAAMSGVTCCLRFPGQLNSDL
RKLAVNLIPFPRLHFFLIGFAPLTSRGSQQYRALSVPELTQQMFDAKNMM
CASDPRHGRYLTASAMFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNMK
SSVCDIPPKGLKMSVTFVGNSTAIQEMFKRVSDQFTAMFRRKAFLHWYTG
EGMDEMEFTEAESNMNDLVSEYQQYQ

Ligand information

>7tns Chain 8 (length=22) Species: 508771 (Toxoplasma gondii ME49) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PTLPFNAQSCYRSEYVAKPLPP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7tns Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures.
Resolution	6.7 Å
Binding residue (original residue number in PDB)	Q43 I356 K359
Binding residue (residue number reindexed from 1)	Q43 I356 K359

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005200	structural constituent of cytoskeleton
GO:0005525	GTP binding

	Biological Process
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0007017	microtubule-based process

	Cellular Component
GO:0005737	cytoplasm
GO:0005874	microtubule

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Cellular Component

External links

PDB	RCSB:7tns, PDBe:7tns, PDBj:7tns
PDBsum	7tns
PubMed	35121661
UniProt	A0A125YWG5

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