Structure of PDB 6gzz Chain C1 Binding Site BS01

Receptor Information
>6gzz Chain C1 (length=272) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVKKFKPYTPSRRFMTVADFSEITKTEPEKSLVKPLKKTGGRNNQGRITV
RFRGGGHKRLYRIIDFKRWDKVGIPAKVAAIEYDPNRSARIALLHYVDGE
KRYIIAPDGLQVGQQVVAGPDAPIQVGNALPLRFIPVGTVVHAVELEPKK
GAKLARAAGTSAQIQGREGDYVILRLPSGELRKVHGECYATVGAVGNADH
KNIVLGKAGRSRWLGRRPHVRGAAMNPVDHPHGGGEGRAPRGRPPASPWG
WQTKGLKTRKRRKPSSRFIIAR
Ligand information
>6gzz Chain A1 (length=2912) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaug
aaggacguggcuaccugcgauaagccagggggagccgguagcgggcgugg
aucccuggauguccgaaugggggaacccggccggcgggaacgccggucac
cgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguaccc
agaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggg
gaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgg
acaccgaauccccagccuagccgaagcuguugggaagcagcgccagagag
ggugaaagccccguaggcgaaagguggggggauaggugaggguacccgag
uaccccgugguucguggagccaugggggaaucugggcggaccaccgccua
aggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaag
gugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcu
uacaagcagucacggccccgcaagggguuguggcgugccuauugaagcau
gagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggc
guagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccga
aaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccaggg
ugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaa
ccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggaga
uagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacug
gggccuguagagcacugauagggcuagggggcccaccagccuaccaaacc
cugucaaacuccgaagggucccagguggagccugggagugagggcgcgag
cgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaagg
cccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcc
aggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcuca
cuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgcc
gaagcugcgggucugggggaugaccccaggcgguaggggagcguucccga
ugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcga
augccggcaugaguaacgauaaagagggugagaaucccucucgccguaag
cccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccua
aggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcc
cuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagcc
auggacgagcccggccagaagcgcagggugggagguaggcaaauccgccu
cccaacaagcucugcgugguggggaagcccguacgggugacaaccccccg
aagccagggagccaagaaaagccucuaagcacaaccugcgggaacccgua
ccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcggga
gaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaag
gggugcucccuggggugaugagccccggggagccgcagugaacaggcucu
ggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggaggu
auagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaa
gccccgaaccgaagccccggugaacggcggccguaacuauaacgguccua
agguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcgua
acgaccggagcgcugucucggcgagggacccggugaaauugaacuggccg
ugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuua
cugcagccugguguuggcucuuggucgcgccugcguaggauaggugggag
ccugugaacccccgccuccgggugggggggaggcgccggugaaauaccac
ccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcg
ggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaa
agguccccucaggcgggacggaaauccgccggagagcgcaaggguagaag
ggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccu
agugaaccgguggucccguguggaagggccaucgaucaacggauaaaagu
uaccccggggauaacaggcugaucucccccgagcguccacagcggcgggg
agguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggu
cccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuca
gaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuu
gaggggggcucuuccuaguacgagaggaccggaagggacgcaccucuggu
uucccagcugucccuccaggggcauaagcuggguagccaugugcggaagg
gauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccu
cccacggcgucaagccgguaaggacccgggaagaccacccgguggauggg
ccggggguguaagcgccgcgaggcguugagccgaccggucccaaucgucc
gaggucuugacc
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>>...<<<....<<<<<<<.......>>>>>>>.......<.<.<<<...
...<<...........<<.<<<....<<..........>>.((......<
<<.....))>>>...>>>...>>...........>>..>>>.>..>....
..<.<<<<<<.........>>>>.>>.>.....<<<<<..<<<.>>>>>.
.>>>............>>>..................<<....>>....>
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..<<<.<<.....<<<<<<<<.<<<..<<<...<<<.....>>>...>>>
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.....>>..<<<<<<....<<<<<....>>>>><<.<<<<<<.....<<<
<<<<<<....<<...<<<<<<.<.<.<<<...........>..>>.>..>
>>>>>>..>>.....>>>>>>>>>.....>>>>>>..>>..<<<<<<<.<
<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<
<((......<<<<<<...........<<..<<<<<<<<<........<<<
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...>>>>>>><<<.<<<<.....>>>>.>>>....>>>>>><<<<<.<..
.<<<......<<<<<.<<<....>>>>>>>>...>>>...>>>>.>>...
..>>.>>><......<<.....<<<<<<.......>>>>>><<<<....<
<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<.<<..
.<<<....<<....>>....>>>...>>....<<<<........>>>>.)
)<<<.<.<<<<......<.<.....<<<<<.<<....<<<..<<<<....
.(((......>>>><<....<<<<<<<.<<<<<<<<..........>>>>
>>>.....>.>>>>>>>...>.>......................>>>..
...>>..>>>>>...........>.>........>>>>..>>>>>>>>..
>>.....<<......>>>>>>>.<<<........>>>..>>>>...<<<.
...<<<<<<<..<<...............<<<<<.....<..>......>
>>>>.<<<<<<...............>>>>>>.............<<<<<
<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.....
..>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<.....<......
..>.....>>...>>>>>>>>..>>>>>...<<.........>>......
.................<<<<<<.....>>>>>>..........>>>>..
.>>.>>>>>>>.....>>..>>>>>>>.>>>.>>.....>.....<<<<.
.........>>>>..<<<<<<<<..((.........<<<<.[..<<<..<
<<<..<<<.<<<<..<<<<.<.......................<.....
..........<..<........>...>.....................>.
............>..>>>>...<<<<......>>>>.....>>>>.>>>.
..>>>>..<<<<.....>>>><<<<<<...........>>>>>>......
..<<<<<<...<.<<<<.......>>>>.>.....<.....((.>....>
>>>>>.....<.....<<......>>......>.<<<....>>>...)).
.......<<<<<<<.((...>>>..))>>>>>>>.............>>>
....]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>
>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<.<......>.>
>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....
<<<<<<<....>>>.>>>>........)).>>>>>>>>....<<<<<<<.
..<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<
...<<<<<<<<<<..))).>>>>>...>>>>>...>>>>.>>>>>...<<
<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>
>>..<<.........>>....<<<<<<<.<........>>>>....<<<<
.<<<.<<<....<<<<<....>>>>>...>>>..>>>..>>>>...>>>>
.....>>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gzz Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Resolution4.13 Å
Binding residue
(original residue number in PDB)
P8 Y9 T10 S12 R13 R14 F15 F21 E30 K31 S32 L33 V34 K38 K39 G41 R43 N44 N45 G47 R48 I49 T50 R52 R54 H58 K59 R60 L61 Y62 R63 K78 Y84 P86 R88 S89 H96 V98 K151 K154 L155 R157 A158 A159 Y172 L177 P178 S179 R183 A199 V205 L206 G207 K208 A209 G210 R213 W214 R218 P219 H220 R222 G223 A225 M226 P228 G234 G235 G236 E237 G238 R239 A240 P241 R242 G243 R244 P246 A247 S248 P249 W250 Q253 T254 K255 G256 L257 K258 T259 R260 K261 R262 R263 K264 R268 I270 R273
Binding residue
(residue number reindexed from 1)
P7 Y8 T9 S11 R12 R13 F14 F20 E29 K30 S31 L32 V33 K37 K38 G40 R42 N43 N44 G46 R47 I48 T49 R51 R53 H57 K58 R59 L60 Y61 R62 K77 Y83 P85 R87 S88 H95 V97 K150 K153 L154 R156 A157 A158 Y171 L176 P177 S178 R182 A198 V204 L205 G206 K207 A208 G209 R212 W213 R217 P218 H219 R221 G222 A224 M225 P227 G233 G234 G235 E236 G237 R238 A239 P240 R241 G242 R243 P245 A246 S247 P248 W249 Q252 T253 K254 G255 L256 K257 T258 R259 K260 R261 R262 K263 R267 I269 R272
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0016740 transferase activity
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6gzz, PDBe:6gzz, PDBj:6gzz
PDBsum6gzz
PubMed30301898
UniProtP60405|RL2_THET8 Large ribosomal subunit protein uL2 (Gene Name=rplB)

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