Structure of PDB 9b5w Chain C Binding Site BS01

Receptor Information
>9b5w Chain C (length=147) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALKRINRELADLGKDPPSSSSAGPVGDDLFHWQATIMGPADSPYAGGVFF
LSIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISK
VLLSISSLLTDPNPDDPLVPEIAHVYKTDRSRYELSAREWTRKYAIG
Ligand information
Ligand IDA1AIV
InChIInChI=1S/C4H8N2/c5-3-1-2-4-6/h1-3,5H2
InChIKeyXGYKKVTZDQDYJQ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7C(CC#N)CN
CACTVS 3.385NCCCC#N
ACDLabs 12.01N#CCCCN
FormulaC4 H8 N2
Name4-aminobutanenitrile
ChEMBL
DrugBank
ZINC
PDB chain9b5w Chain D Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB9b5w Structural basis for transthiolation intermediates in the ubiquitin pathway
Resolution3.96 Å
Binding residue
(original residue number in PDB)		C85 L86 D117
Binding residue
(residue number reindexed from 1)		C84 L85 D116
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.2.23: E2 ubiquitin-conjugating enzyme.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0061631 ubiquitin conjugating enzyme activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032933 SREBP signaling pathway
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:9b5w, PDBe:9b5w, PDBj:9b5w
PDBsum9b5w
PubMed39143218
UniProtP46595|UBC4_SCHPO Ubiquitin-conjugating enzyme E2 4 (Gene Name=ubc4)

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