Structure of PDB 8z9r Chain C Binding Site BS01

Receptor Information
>8z9r Chain C (length=747) Species: 126796 (Thogoto virus (isolate SiAr 126)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESECTLRALVEEYNGACKEAPKEMSKQFTDYNTFKRYTTSKKDHAPQMRL
VYSVRKPWPISMTPSKEIPLVFNGTKLKDTILDLGESKRTRANIVVPDYW
SKYGSQTSLEVVNAILYAEDLKVQRFFSTEWGEIRYGRMLPFRKPVQACP
TIEEVNPASIPHTLLQVFCPQYTTLDSKRKAHMGAVEKLKRVMEPICKVQ
TQESAVHIARSLIDSNKKWLPTVVDHTPRTAEMAHFLCSKYHYVHTNTQD
LSDTRSIDNLCGELVKRSLKCRCPKETLVANLDKITIQGRPMREVLADHD
GELPYLGICRVAMGLSTHHTMKIRSTKFSILNSDHPRIEVKKVFSLSPDV
QVTIPYRRFKGKAKVYFQNDQIQGYFSCTDRQIDEIKISAPKNAPLLEPL
LDICYYGSFIEPGFEQTFGYPAGKREFVDSFFMHHSKDHKAFLIHMGLDK
DLSLPLSPELNWKEPALSKVCRVTELDSTVQPYTSATREFVLGETLNVYT
QHENGLELLICPTEIRSTRGPLPPGTNLSGSEFIDIYQDPFSRAKSLLKS
TILHAERCKEFVGNMLEEYQDPAETTVQSLVPINTWGKSAKRKLQEEITS
DPDWHQCPRKRAKMSYLAIIAGSIQDRDKKQTNVPRAFMLRGSQIEYDMK
ATRGLVVDTTNRIIVGGETVLREGKGGPEGYVQTGVFEEQPRCYLVDTPD
HGLSMGLSRFCVHSQGRYFQYEKKISIWEETDNIKATIDSQRDLKRR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8z9r Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses
Resolution2.58 Å
Binding residue
(original residue number in PDB)		H51 E210 H214 K225
Binding residue
(residue number reindexed from 1)		H44 E203 H207 K218
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0075526 cap snatching
Cellular Component
GO:0042025 host cell nucleus
GO:0044423 virion component

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8z9r, PDBe:8z9r, PDBj:8z9r
PDBsum8z9r
PubMed38816392
UniProtQ9YNA4|PB2_THOGV Polymerase basic protein 2 (Gene Name=Segment)

[Back to BioLiP]