Structure of PDB 8x22 Chain C Binding Site BS01

Receptor Information

>8x22 Chain C (length=553) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKI
GPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGL
KQKKSVTVLDVGDAFYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLP
MGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKD
SWTVNDIQKLVGKLNWASQIYAGIKVRQLSKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMKGAHTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEA
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAANRET
KLGKAGYVTDRGRQKVVPLTDTTNQKTELQAIHLALQDSGLEVNIVTDSQ
YALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDK
LVS

Ligand information

>8x22 Chain F (length=38) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

taatcgccccccttcggtgctttgcaccgaaggggggc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8x22 Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations.
Resolution	2.31 Å
Binding residue (original residue number in PDB)	W24 F61 I63 D76 R78 E89 I94 G152 P157 Y183 M184 D185 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 G359 H361 K374 R448 T473 Q475 K476 Y501
Binding residue (residue number reindexed from 1)	W24 F61 I63 D76 R78 E89 I94 G152 P157 Y183 M184 D185 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 G359 H361 K374 R448 T473 Q475 K476 Y501

External links

PDB	RCSB:8x22, PDBe:8x22, PDBj:8x22
PDBsum	8x22
PubMed	38977798
UniProt	P12497\|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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