Structure of PDB 8wx0 Chain C Binding Site BS01

Receptor Information
>8wx0 Chain C (length=593) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IDEGVFETTATIDNGSFGTRTIRFETGRLALQAAGAVVAYLDDDNMLLSA
TTASKNPKEHFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTCR
LIDRPLRPSFVDGLRNEIQIVVTILSLDPGDLYDVLAINAASASTQLGGL
PFSGPIGGVRVALIDGTWVGFPTVDQIERAVFDMVVAGRIVEGDVAIMMV
EAEATENVVELVEGGAQAPTESVVAAGLEAAKPFIAALCTAQQELADAAG
KSGKPTVDFPVFPDYGEDVYYSVSSVATDELAAALTIGGKAERDQRIDEI
KTQVVQRLADTYEGREKEVGAALRALTKKLVRQRILTDHFRIDGRGITDI
RALSAEVAVVPRAHGSALFERGETQILGVTTLDMIKMAQQIDSLGPETSK
RYMHHYNFPPFSTGETGRVGSPKRREIGHGALAERALVPVLPSVEEFPYA
IRQVSEALGSNGSTSMGSVCASTLALLNAGVPLKAPVAGIAMGLVSDDIQ
VEGAVDGVVERRFVTLTDILGAEDAFGDMDFKVAGTKDFVTALQLDTKLD
GIPSQVLAGALEQAKDARLTILEVMAEAIDRPDEMSPYAPRVT
Ligand information
Receptor-Ligand Complex Structure
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PDB8wx0 Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		G87 F89 D397 S426
Binding residue
(residue number reindexed from 1)		G82 F84 D392 S421
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004654 polyribonucleotide nucleotidyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wx0, PDBe:8wx0, PDBj:8wx0
PDBsum8wx0
PubMed38395123
UniProtP9WI57|PNP_MYCTU Polyribonucleotide nucleotidyltransferase (Gene Name=pnp)

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