Structure of PDB 8wpf Chain C Binding Site BS01

Receptor Information
>8wpf Chain C (length=218) Species: 10244 (Monkeypox virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNSVTISHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFF
IQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLT
GVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITK
HVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDHQFEKDRSFEIINV
LLELDNKTPINWAQGFIY
Ligand information
>8wpf Chain I (length=41) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cacgaattaagcaattcgtaatcatggtcatagctcccgcg
Receptor-Ligand Complex Structure
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PDB8wpf Structural insights into the assembly and mechanism of monkeypox virus DNA polymerase complex F8-A22-E4-H5
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D68 Y70 K87 S88 T130 K160 T161 Y180 H181 A184 R185 Q188
Binding residue
(residue number reindexed from 1)		D68 Y70 K87 S88 T130 K160 T161 Y180 H181 A184 R185 Q188
Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8wpf, PDBe:8wpf, PDBj:8wpf
PDBsum8wpf
PubMed37995690
UniProtM1LL92|UNG_MONPV Uracil-DNA glycosylase (Gene Name=OPG116)

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