Structure of PDB 8w0a Chain C Binding Site BS01

Receptor Information

>8w0a Chain C (length=636) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPT
SAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIK
VDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE
LHMLGDSHRGYLLELLLTKICYITRKSNAVQIVGMSATLPNLELVASWLN
AELYHTDFRPVPLLESVKVGNSIYDSSMKLVREDHVVSLCYETICDNHSV
LLFCPSKKWCEKLADIIAREFYNLHEQKELLEVMDQLRRLPSGLDSVLQK
TVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRV
IIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIAL
LQGSLKPVRSCLVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMG
AIEACVMWLLENEFIQVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKG
FVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEE
GFLARCQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQ
QSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFG

Ligand information

>8w0a Chain D (length=7) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	8w0a Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	F146 V147 G173 T190 E192 R193 R200 K347 A418 S444 S622 E659 V757 G760 M761 V764
Binding residue (residue number reindexed from 1)	F79 V80 G106 T123 E125 R126 R133 K257 A311 S337 S481 E518 V605 G608 M609 V612

External links

PDB	RCSB:8w0a, PDBe:8w0a, PDBj:8w0a
PDBsum	8w0a
PubMed	38895274
UniProt	O75417\|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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