Structure of PDB 8u61 Chain C Binding Site BS01

Receptor Information
>8u61 Chain C (length=692) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSWIQKVLEQIMDSPRQCVTPSEVVPVTVLAVQRYLLEDEPRDTVPKPPL
YCYDVTISDGVYQEKCYLDPSLNSLVYQNILKVGIQMRISRVSCLYNEKR
IGQGILCIDNVHCGETSDSISLETPFRNRAHQEKPERPLRGGKSHYLALW
NNEDPYGDIWLTDKQPEEHNFSDTKIISLSHLEMTWTNRRNFPALLVRIL
HKSKLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNALCPEWYKSLRV
GLVLLLQDYSVKKSYPFRIQPVPVDPQIKLISTMEICLNLRDPPTNIIII
PEKQVKPEWRLPKLNHRFTTRSELDDMPENCICDVIGLLVFVGRVQRSKK
KENREDFWSYRWIHIADGTSEQPFIVELFSTSQPEIFENIYPMAYFVCTQ
LKVVRNDNQVPKLLYLTTTNESGVFITGHRGQPYTYDAKVKNFIQWIRTK
SDSGEQKNMVIGGYYPYPPVPETFSKYSSSIKVESLLTAISEVRKEIEDL
QYREQKRIAIQGIITAIKYIPHSISDRWESQGLIDHLHYSRVYPESIPRK
FMFEHRKFLSDQYNSQPAKYVPPEGRPPKLDDFKSARSLGHFEVTILGLN
HEIAIDVAFLPMYCPEDIRTSQIDTLLTSMNYSCAYPQDTTGNDRLPGPR
AVAGDIIKAATELDRVHIVGILDICNLGNNKVEVYLHKIYSP
Ligand information
Receptor-Ligand Complex Structure
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PDB8u61 Structure of RADX and mechanism for regulation of RAD51 nucleofilaments
Resolution4.0 Å
Binding residue
(original residue number in PDB)		R232 R248 Y250 Q262 F264 W279 Y307 R310 N331 R333
Binding residue
(residue number reindexed from 1)		R190 R206 Y208 Q220 F222 W237 Y265 R268 N289 R291
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006282 regulation of DNA repair
GO:2000042 negative regulation of double-strand break repair via homologous recombination
Cellular Component
GO:0005657 replication fork
GO:0005694 chromosome
GO:0016607 nuclear speck

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8u61, PDBe:8u61, PDBj:8u61
PDBsum8u61
PubMed38466836
UniProtQ6NSI4|RADX_HUMAN RPA-related protein RADX (Gene Name=RADX)

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