Structure of PDB 8tzr Chain C Binding Site BS01

Receptor Information

>8tzr Chain C (length=273) Species: 9606 (Homo sapiens)

EPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQ
TSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSL
DQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDE
FTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKDNPEYSPDPS
IYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAE
KQMKDKQDEEQRLKEEEEDKKRK

Ligand information

• Ligand ID: BMA
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
• InChIKey: WQZGKKKJIJFFOK-RWOPYEJCSA-N
• SMILES:
  CACTVS 3.341: OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: beta-D-mannopyranose;
  beta-D-mannose;
  D-mannose;
  mannose
• ZINC: ZINC000003830679
• PDB chain: 8tzr Chain D Residue 3

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8tzr Structure of human Wnt3a bound to WLS and CALR
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): C105 C137 W319
• Binding residue (residue number reindexed from 1): C88 C120 W215
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0051082 unfolded protein binding

Biological Process

• GO:0006457 protein folding

Cellular Component

• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:8tzr, PDBe:8tzr, PDBj:8tzr
• PDBsum: 8tzr
• UniProt: P27797|CALR_HUMAN Calreticulin (Gene Name=CALR)